Inter-individual differences in the blood pressure lowering effects of dietary nitrate: A randomised double-blind placebo-controlled replicate crossover trial Article Swipe
Eleanor Hayes
,
Shatha Alhulaefi
,
Mario Siervo
,
Eleanor Whyte
,
Rachel Kimble
,
Jamie Matu
,
Alex Griffiths
,
Marc Sim
,
Mia Burleigh
,
Chris Easton
,
Lorenzo Lolli
,
Greg Atkinson
,
John C. Mathers
,
Oliver M. Shannon
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.12.02.24318286
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.12.02.24318286
Purpose Dietary nitrate supplementation increases nitric oxide (NO) bioavailability and reduces blood pressure (BP). Inter-individual differences in these responses are suspected but have not been investigated using robust designs, e.g., replicate crossover, and appropriate statistical models. We examined the within-individual consistency of the effects of dietary nitrate supplementation on NO biomarkers and BP, and quantified inter-individual response differences. Methods Fifteen healthy males visited the laboratory four times. On two visits, participants consumed 140ml nitrate-rich beetroot juice (∼14.0mmol nitrate) and, on the other two visits, they consumed 140ml nitrate-depleted beetroot juice (∼0.03mmol nitrate). Plasma nitrate and nitrite concentrations were measured 2.5 hours post-supplementation. BP was measured pre– and 2.5 hours post-supplementation. Between-replicate correlations were quantified for the placebo-adjusted post-supplementation plasma nitrate and nitrite concentrations and pre-to-post changes in BP. Within-participant linear mixed models (LLM) and a meta-analytic approach estimated participant-by-condition treatment response variability. Results Nitrate-rich beetroot juice supplementation elevated plasma nitrate and nitrite concentrations and reduced systolic (mean:-7mmHg, 95%CI: –3 to –11mmHg) and diastolic (mean:-6mmHg, 95%CI: –2 to –9mmHg) BP versus placebo. The LLM participant-by-condition interaction response variability was ±7mmHg (95%CI: 3 to 9mmHg) for systolic BP and consistent with the treatment effect heterogeneity τ=± 7mmHg (95%CI: 5 to 12mmHg) derived from the meta-analytic approach. The between-replicate correlations were moderate-to-large for plasma nitrate, nitrite and systolic BP (r=0.55 to 0.91). Conclusions The effects of dietary nitrate supplementation on NO biomarkers and systolic BP varied significantly from participant to participant. The causes of this inter-individual variation deserve further investigation. Trial registration: https://clinicaltrials.gov/study/NCT05514821 .
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.12.02.24318286
- https://www.medrxiv.org/content/medrxiv/early/2024/12/02/2024.12.02.24318286.full.pdf
- OA Status
- green
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404917966
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404917966Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2024.12.02.24318286Digital Object Identifier
- Title
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Inter-individual differences in the blood pressure lowering effects of dietary nitrate: A randomised double-blind placebo-controlled replicate crossover trialWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-12-02Full publication date if available
- Authors
-
Eleanor Hayes, Shatha Alhulaefi, Mario Siervo, Eleanor Whyte, Rachel Kimble, Jamie Matu, Alex Griffiths, Marc Sim, Mia Burleigh, Chris Easton, Lorenzo Lolli, Greg Atkinson, John C. Mathers, Oliver M. ShannonList of authors in order
- Landing page
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https://doi.org/10.1101/2024.12.02.24318286Publisher landing page
- PDF URL
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https://www.medrxiv.org/content/medrxiv/early/2024/12/02/2024.12.02.24318286.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.medrxiv.org/content/medrxiv/early/2024/12/02/2024.12.02.24318286.full.pdfDirect OA link when available
- Concepts
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Replicate, Crossover study, Placebo, Crossover, Blood pressure, Double blind, Medicine, Nitrate, Internal medicine, Physical therapy, Statistics, Biology, Computer science, Mathematics, Alternative medicine, Ecology, Pathology, Artificial intelligenceTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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63Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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