Interaction Between Mesenchymal Stem Cells and Retinal Degenerative Microenvironment Article Swipe
Lin Yu
,
Xiang Ren
,
Yongjiang Chen
,
Danian Chen
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fnins.2020.617377
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fnins.2020.617377
Retinal degenerative diseases (RDDs) are a group of diseases contributing to irreversible vision loss with yet limited therapies. Stem cell-based therapy is a promising novel therapeutic approach in RDD treatment. Mesenchymal stromal/stem cells (MSCs) have emerged as a leading cell source due to their neurotrophic and immunomodulatory capabilities, limited ethical concerns, and low risk of tumor formation. Several pre-clinical studies have shown that MSCs have the potential to delay retinal degeneration, and recent clinical trials have demonstrated promising safety profiles for the application of MSCs in retinal disease. However, some of the clinical-stage MSC therapies have been unable to meet primary efficacy end points, and severe side effects were reported in some retinal “stem cell” clinics. In this review, we provide an update of the interaction between MSCs and the RDD microenvironment and discuss how to balance the therapeutic potential and safety concerns of MSCs' ocular application.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnins.2020.617377
- https://www.frontiersin.org/articles/10.3389/fnins.2020.617377/pdf
- OA Status
- gold
- Cited By
- 19
- References
- 136
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3123114720
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3123114720Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fnins.2020.617377Digital Object Identifier
- Title
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Interaction Between Mesenchymal Stem Cells and Retinal Degenerative MicroenvironmentWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-21Full publication date if available
- Authors
-
Lin Yu, Xiang Ren, Yongjiang Chen, Danian ChenList of authors in order
- Landing page
-
https://doi.org/10.3389/fnins.2020.617377Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fnins.2020.617377/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fnins.2020.617377/pdfDirect OA link when available
- Concepts
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Mesenchymal stem cell, Stem cell, Retinal, Neuroscience, Biology, Cell biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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19Total citation count in OpenAlex
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2025: 1, 2024: 5, 2023: 7, 2022: 3, 2021: 3Per-year citation counts (last 5 years)
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136Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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