Interaction between nanomaterials and the innate immune system across evolution Article Swipe
Diana Boraschi
,
Laura Canesi
,
Damjana Drobne
,
Birgit Kemmerling
,
Annalisa Pinsino
,
Petra Procházková
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/brv.12928
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/brv.12928
Interaction of engineered nanomaterials (ENMs) with the immune system mainly occurs with cells and molecules of innate immunity, which are present in interface tissues of living organisms. Immuno‐nanotoxicological studies aim at understanding if and when such interaction is inconsequential or may cause irreparable damage. Since innate immunity is the first line of immune reactivity towards exogenous agents and is highly conserved throughout evolution, this review focuses on the major effector cells of innate immunity, the phagocytes, and their major sensing receptors, Toll‐like receptors (TLRs), for assessing the modes of successful versus pathological interaction between ENMs and host defences. By comparing the phagocyte‐ and TLR‐dependent responses to ENMs in plants, molluscs, annelids, crustaceans, echinoderms and mammals, we aim to highlight common recognition and elimination mechanisms and the general sufficiency of innate immunity for maintaining tissue integrity and homeostasis.
Related Topics
Concepts
Innate immune system
Biology
Immunity
Effector
Immune system
Pattern recognition receptor
Immunology
Receptor
Cell biology
Genetics
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1111/brv.12928
- OA Status
- hybrid
- Cited By
- 25
- References
- 223
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4316174670
All OpenAlex metadata
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https://openalex.org/W4316174670Canonical identifier for this work in OpenAlex
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https://doi.org/10.1111/brv.12928Digital Object Identifier
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Interaction between nanomaterials and the innate immune system across evolutionWork title
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reviewOpenAlex work type
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enPrimary language
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2023Year of publication
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2023-01-14Full publication date if available
- Authors
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Diana Boraschi, Laura Canesi, Damjana Drobne, Birgit Kemmerling, Annalisa Pinsino, Petra ProcházkováList of authors in order
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https://doi.org/10.1111/brv.12928Publisher landing page
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hybridOpen access status per OpenAlex
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Innate immune system, Biology, Immunity, Effector, Immune system, Pattern recognition receptor, Immunology, Receptor, Cell biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
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25Total citation count in OpenAlex
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2025: 9, 2024: 7, 2023: 9Per-year citation counts (last 5 years)
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