Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver disease activity in western-diet fed mice Article Swipe
Sreepradha Eswaran
,
Laura Gebert
,
Sarah Schraven
,
Nicole Treichel
,
Thomas Ritz
,
Stephan Hamm
,
Achim Seeger
,
Fabian Kießling
,
Thomas Clavel
,
Stephan Dreschers
,
Norbert Wagner
,
Angela Schippers
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-025-11555-0
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-025-11555-0
Metabolic dysfunction associated steatotic liver disease (MASLD) presents a growing global health problem. Disease progression is promoted not only by hepatic leukocyte accumulation but also by inflammatory signals from adipose tissue and an altered gut microbiome. To determine the contribution of intercellular adhesion molecule-1 (ICAM-1) to MASLD pathogenesis, male mice with an ICAM-1 mutation (Icam1 tmBay ) and wild type (WT) mice were compared in 12 and 24-week feeding experiments with a Western-style diet (WD) containing 40 kcal% fat, 20 kcal% fructose, and 2% cholesterol. WD-induced MASLD was accompanied by increased ICAM-1 expression in liver, epididymal white adipose tissue (EWAT), and intestine in WT mice. WD-fed Icam1 tmBay mice exhibited increased circulating neutrophils, higher frequencies of inflammatory leukocytes in EWAT, and a worsened glucose tolerance when compared to WT mice. In contrast, the mutation resulted in reduced WD-induced liver disease activity and less accumulation of intrahepatic leukocytes. WD-feeding caused substantial changes in fecal microbiota with decreased microbial diversity that differed between the mouse strains. In conclusion, ICAM-1 positively regulates adipose tissue homeostasis and protects from insulin resistance but promotes liver damage in diet-induced obesity. This points to organ-specific roles for ICAM-1 and the potential of liver-specific targeting of ICAM-1 for treatment of MASLD.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-025-11555-0
- OA Status
- gold
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412489093
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4412489093Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41598-025-11555-0Digital Object Identifier
- Title
-
Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver disease activity in western-diet fed miceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-07-16Full publication date if available
- Authors
-
Sreepradha Eswaran, Laura Gebert, Sarah Schraven, Nicole Treichel, Thomas Ritz, Stephan Hamm, Achim Seeger, Fabian Kießling, Thomas Clavel, Stephan Dreschers, Norbert Wagner, Angela SchippersList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-025-11555-0Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1038/s41598-025-11555-0Direct OA link when available
- Concepts
-
Insulin resistance, Adipose tissue, Endocrinology, Internal medicine, White adipose tissue, Inflammation, Fatty liver, Biology, Pathogenesis, Gut flora, Intercellular Adhesion Molecule-1, ICAM-1, Insulin, Cell adhesion molecule, Immunology, Medicine, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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58Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| publication_date | 2025-07-16 |
| publication_year | 2025 |
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