Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex Article Swipe
Takashi Sato
,
Takahide Itokazu
,
Hironobu Osaki
,
Makoto Ohtake
,
Tetsuya Yamamoto
,
Kazuhiro Sohya
,
Takakuni Maki
,
Tatsuo K. Sato
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.7554/elife.50855
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.7554/elife.50855
Cortical plasticity is fundamental to motor recovery following cortical perturbation. However, it is still unclear how this plasticity is induced at a functional circuit level. Here, we investigated motor recovery and underlying neural plasticity upon optogenetic suppression of a cortical area for eye movement. Using a visually-guided eye movement task in mice, we suppressed a portion of the secondary motor cortex (MOs) that encodes contraversive eye movement. Optogenetic unilateral suppression severely impaired contraversive movement on the first day. However, on subsequent days the suppression became inefficient and capability for the movement was restored. Longitudinal two-photon calcium imaging revealed that the regained capability was accompanied by an increased number of neurons encoding for ipsiversive movement in the unsuppressed contralateral MOs. Additional suppression of the contralateral MOs impaired the recovered movement again, indicating a compensatory mechanism. Our findings demonstrate that repeated optogenetic suppression leads to functional recovery mediated by the contralateral hemisphere.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.50855
- OA Status
- gold
- Cited By
- 17
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2989378546
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2989378546Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.7554/elife.50855Digital Object Identifier
- Title
-
Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortexWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-11-05Full publication date if available
- Authors
-
Takashi Sato, Takahide Itokazu, Hironobu Osaki, Makoto Ohtake, Tetsuya Yamamoto, Kazuhiro Sohya, Takakuni Maki, Tatsuo K. SatoList of authors in order
- Landing page
-
https://doi.org/10.7554/elife.50855Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.7554/elife.50855Direct OA link when available
- Concepts
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Optogenetics, Neuroscience, Motor cortex, Eye movement, Neuroplasticity, Frontal cortex, Calcium imaging, Psychology, Biology, Medicine, Stimulation, Calcium, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
17Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 3, 2023: 2, 2022: 4, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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46Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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