Interleukin-1 Receptor Antagonist Reduces Neonatal Lipopolysaccharide-Induced Long-Lasting Neurobehavioral Deficits and Dopaminergic Neuronal Injury in Adult Rats Article Swipe
Yi Pang
,
Lu‐Tai Tien
,
Hobart Zhu
,
Ju-ying Shen
,
C. Wright
,
Tembra Jones
,
Samir Mamoon
,
Abhay Bhatt
,
Zhengwei Cai
,
Lir‐Wan Fan
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.3390/ijms16048635
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.3390/ijms16048635
Our previous study showed that a single lipopolysaccharide (LPS) treatment to neonatal rats could induce a long-lasting neuroinflammatory response and dopaminergic system injury late in life. This is evidenced by a sustained activation of microglia and elevated interleukin-1β (IL-1β) levels, as well as reduced tyrosine hydroxylase (TH) expression in the substantia nigra (SN) of P70 rat brain. The object of the current study was to test whether co-administration of IL-1 receptor antagonist (IL-1ra) protects against LPS-induced neurological dysfunction later in life. LPS (1 mg/kg) with or without IL-1ra (0.1 mg/kg), or sterile saline was injected intracerebrally into postnatal day 5 (P5) Sprague-Dawley male rat pups. Motor behavioral tests were carried out from P7 to P70 with subsequent examination of brain injury. Our results showed that neonatal administration of IL-1ra significantly attenuated LPS-induced motor behavioral deficits, loss of TH immunoreactive neurons, as well as microglia activation in the SN of P70 rats. These data suggest that IL-1β may play a pivotal role in mediating a chronic neuroinflammation status by a single LPS exposure in early postnatal life, and blockading IL-1β might be a novel approach to protect the dopaminergic system against perinatal infection/inflammation exposure.
Related Topics
Concepts
Dopaminergic
Neuroinflammation
Microglia
Substantia nigra
Tyrosine hydroxylase
Lipopolysaccharide
Receptor antagonist
Medicine
Antagonist
Endocrinology
Internal medicine
Pharmacology
Dopamine
Receptor
Inflammation
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms16048635
- https://www.mdpi.com/1422-0067/16/4/8635/pdf?version=1429255809
- OA Status
- gold
- Cited By
- 32
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2091148422
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2091148422Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms16048635Digital Object Identifier
- Title
-
Interleukin-1 Receptor Antagonist Reduces Neonatal Lipopolysaccharide-Induced Long-Lasting Neurobehavioral Deficits and Dopaminergic Neuronal Injury in Adult RatsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-04-17Full publication date if available
- Authors
-
Yi Pang, Lu‐Tai Tien, Hobart Zhu, Ju-ying Shen, C. Wright, Tembra Jones, Samir Mamoon, Abhay Bhatt, Zhengwei Cai, Lir‐Wan FanList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms16048635Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/16/4/8635/pdf?version=1429255809Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/16/4/8635/pdf?version=1429255809Direct OA link when available
- Concepts
-
Dopaminergic, Neuroinflammation, Microglia, Substantia nigra, Tyrosine hydroxylase, Lipopolysaccharide, Receptor antagonist, Medicine, Antagonist, Endocrinology, Internal medicine, Pharmacology, Dopamine, Receptor, InflammationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
32Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 4, 2023: 3, 2022: 1, 2020: 3Per-year citation counts (last 5 years)
- References (count)
-
56Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W1979919872, https://openalex.org/W2158698668, https://openalex.org/W1815071312, https://openalex.org/W2007322682, https://openalex.org/W1964039180, https://openalex.org/W2017975056, https://openalex.org/W4234317413, https://openalex.org/W2007305673, https://openalex.org/W2057913943, https://openalex.org/W1998499723, https://openalex.org/W2032516641, https://openalex.org/W2049392449, https://openalex.org/W1965245442, https://openalex.org/W2105614635, https://openalex.org/W2082179108, https://openalex.org/W1997510003, https://openalex.org/W2149298826, https://openalex.org/W1990872391, https://openalex.org/W2080946103, https://openalex.org/W1993376226, https://openalex.org/W2039928597, https://openalex.org/W1967659552, https://openalex.org/W2156168338, https://openalex.org/W1985367066, https://openalex.org/W2109759840, https://openalex.org/W1747110054, https://openalex.org/W2125788813, https://openalex.org/W2080499615, https://openalex.org/W2126457554, https://openalex.org/W2072734557, https://openalex.org/W2094045218, https://openalex.org/W2123355863, https://openalex.org/W1502386647, https://openalex.org/W2015548551, https://openalex.org/W1965942744, https://openalex.org/W2072942101, https://openalex.org/W2111565797, https://openalex.org/W2036386442, https://openalex.org/W2166435142, https://openalex.org/W2038647795, https://openalex.org/W2057037496, https://openalex.org/W2477593094, https://openalex.org/W2043886102, https://openalex.org/W2017083493, https://openalex.org/W2101725281, https://openalex.org/W2008108982, https://openalex.org/W2143142619, https://openalex.org/W2010395737, https://openalex.org/W1970930843, https://openalex.org/W1564437189, https://openalex.org/W2032421019, https://openalex.org/W2038576287, https://openalex.org/W6813156309, https://openalex.org/W4233971050, https://openalex.org/W2005702717, https://openalex.org/W2244276231 |
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| abstract_inverted_index.P70 | 54, 114, 149 |
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| abstract_inverted_index.(0.1 | 88 |
| abstract_inverted_index.(P5) | 100 |
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