Interleukin-10 and Interferon-γ Levels in Patients with Cutaneous Leishmaniasis Treated with Cryotherapy. Article Swipe
Farhad Handjani
,
Saeed Reza Yousef
,
Nasrin Saki
,
Nasrin Hamidizadeh
·
YOU?
·
· 2017
· Open Access
·
YOU?
·
· 2017
· Open Access
·
Pentavalent antimonials, as the 1st choice for the treatment of cutaneous leishmaniasis (CL), have various side effects. Also, there are some reports of drug resistance. Due to its safety, cryotherapy can be a good alternative or complementary treatment in CL. The aim of this study was to explore the possible systemic immunological mechanisms of cryotherapy besides its local effects in the treatment of CL. Twenty patients with CL were selected. The disease was confirmed via a direct smear. A venous blood sample was collected to determine IL-10 and IFN-γ levels before starting cryotherapy. Then, 1 week after 8 sessions of cryotherapy were completed (i.e., 63 d), a 2nd venous sample was taken in order to compare the results with the pretreatment levels of these cytokines using the ELISA method. Cryotherapy resulted in no change in the levels of IL-10 and significantly increased the IFN-γ levels in our patients with CL. Given these inconclusive or even mixed results, a larger sample size is needed in order to better assess the systemic immunological effects of cryotherapy.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://pubmed.ncbi.nlm.nih.gov/29234182
- OA Status
- green
- Cited By
- 2
- References
- 15
- Related Works
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- OpenAlex ID
- https://openalex.org/W2605293211
All OpenAlex metadata
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https://openalex.org/W2605293211Canonical identifier for this work in OpenAlex
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Interleukin-10 and Interferon-γ Levels in Patients with Cutaneous Leishmaniasis Treated with Cryotherapy.Work title
- Type
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articleOpenAlex work type
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enPrimary language
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2017Year of publication
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2017-09-01Full publication date if available
- Authors
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Farhad Handjani, Saeed Reza Yousef, Nasrin Saki, Nasrin HamidizadehList of authors in order
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https://pubmed.ncbi.nlm.nih.gov/29234182Publisher landing page
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YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/5722967Direct OA link when available
- Concepts
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Cryotherapy, Medicine, Cutaneous leishmaniasis, Dermatology, Venous blood, Leishmaniasis, Surgery, Internal medicine, ImmunologyTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2020: 1, 2019: 1Per-year citation counts (last 5 years)
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15Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.method. | 128 |
| abstract_inverted_index.reports | 21 |
| abstract_inverted_index.results | 117 |
| abstract_inverted_index.safety, | 28 |
| abstract_inverted_index.various | 14 |
| abstract_inverted_index.effects. | 16 |
| abstract_inverted_index.patients | 65, 147 |
| abstract_inverted_index.possible | 49 |
| abstract_inverted_index.resulted | 130 |
| abstract_inverted_index.results, | 156 |
| abstract_inverted_index.sessions | 98 |
| abstract_inverted_index.starting | 91 |
| abstract_inverted_index.systemic | 50, 169 |
| abstract_inverted_index.collected | 83 |
| abstract_inverted_index.completed | 102 |
| abstract_inverted_index.confirmed | 73 |
| abstract_inverted_index.cutaneous | 10 |
| abstract_inverted_index.cytokines | 124 |
| abstract_inverted_index.determine | 85 |
| abstract_inverted_index.increased | 141 |
| abstract_inverted_index.selected. | 69 |
| abstract_inverted_index.treatment | 8, 37, 61 |
| abstract_inverted_index.mechanisms | 52 |
| abstract_inverted_index.Cryotherapy | 129 |
| abstract_inverted_index.Pentavalent | 0 |
| abstract_inverted_index.alternative | 34 |
| abstract_inverted_index.cryotherapy | 29, 54, 100 |
| abstract_inverted_index.resistance. | 24 |
| abstract_inverted_index.<i>mixed</i> | 155 |
| abstract_inverted_index.antimonials, | 1 |
| abstract_inverted_index.cryotherapy. | 92, 173 |
| abstract_inverted_index.pretreatment | 120 |
| abstract_inverted_index.complementary | 36 |
| abstract_inverted_index.immunological | 51, 170 |
| abstract_inverted_index.leishmaniasis | 11 |
| abstract_inverted_index.significantly | 140 |
| abstract_inverted_index.<i>inconclusive</i> | 152 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8600000143051147 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.70070714 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |