Interleukin-10 suppresses lipid metabolism-mediated intestinal inflammation Article Swipe
Related Concepts
Lipid metabolism
Inflammation
Metabolism
Interleukin
Chemistry
Immunology
Biochemistry
Medicine
Cytokine
Tristram A.J. Ryan
,
Ivan Zanoni
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/lifemeta/loae011
· OA: W4393186529
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/lifemeta/loae011
· OA: W4393186529
In a recent paper published in <i>Nature</i>, York <i>et al</i>. reported that the anti-inflammatory cytokine IL-10 regulates sphingolipid metabolism to limit NF-κB-mediated inflammation. Deletion of <i>Il10</i> in mice, or genetic mutation of <i>IL10</i> in humans, predisposes to inflammatory bowel disease, which may be overcome by restoring homeostatic sphingolipid metabolism.
Related Topics
Finding more related topics…