Interleukin-7 expression by CAR-T cells improves CAR-T cell survival and efficacy in chordoma Article Swipe
Huantong Wu
,
Zhuofan Xu
,
Maoyang Qi
,
Penghao Liu
,
Boyan Zhang
,
Zhenglin Wang
,
Ge Chen
,
Xiaohai Liu
,
Junqi Liu
,
Wei Wei
,
Wanru Duan
,
Zan Chen
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s00262-024-03756-9
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s00262-024-03756-9
Chordoma is a rare bone tumor that frequently recurs after surgery, and the prognosis is poor with current treatments. This study aimed to identify potential novel immunotherapeutic targets for chordomas by identifying target proteins in clinical samples as well as tumor microenvironmental factors to enhance efficacy. Fourteen chordoma samples were analyzed by single-cell RNA sequencing, and B7–H3 and IL-7 were identified as potential targets and potentiators, respectively. B7–H3-targeted chimeric antigen receptor T (CAR-T) cells and B7–H3 CAR-T cells expressing IL-7 were synthesized and their anti-tumor activity evaluated in vitro, including in primary chordoma organoid models. The B7–H3 CAR-T/IL-7 therapy showed enhanced cytotoxicity and prolonged duration of action against tumor cells. Additionally, IL-7 modulated favorable subpopulations of cultured CAR-T cells, diminished immune checkpoint expression on T-cell surfaces, and enhanced T-cell functionality. The incorporation of IL-7 molecules into the B7–H3 CAR structure augmented CAR-T-cell function and improved CAR-T-cell efficacy, thus providing a novel dual therapeutic strategy for chordoma treatment.
Related Topics
Concepts
Chimeric antigen receptor
Cancer research
Chordoma
Immunotherapy
T cell
Biology
Immune system
Medicine
Immunology
Pathology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s00262-024-03756-9
- https://link.springer.com/content/pdf/10.1007/s00262-024-03756-9.pdf
- OA Status
- gold
- Cited By
- 9
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401250983
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401250983Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s00262-024-03756-9Digital Object Identifier
- Title
-
Interleukin-7 expression by CAR-T cells improves CAR-T cell survival and efficacy in chordomaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-02Full publication date if available
- Authors
-
Huantong Wu, Zhuofan Xu, Maoyang Qi, Penghao Liu, Boyan Zhang, Zhenglin Wang, Ge Chen, Xiaohai Liu, Junqi Liu, Wei Wei, Wanru Duan, Zan ChenList of authors in order
- Landing page
-
https://doi.org/10.1007/s00262-024-03756-9Publisher landing page
- PDF URL
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https://link.springer.com/content/pdf/10.1007/s00262-024-03756-9.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://link.springer.com/content/pdf/10.1007/s00262-024-03756-9.pdfDirect OA link when available
- Concepts
-
Chimeric antigen receptor, Cancer research, Chordoma, Immunotherapy, T cell, Biology, Immune system, Medicine, Immunology, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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9Total citation count in OpenAlex
- Citations by year (recent)
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2025: 9Per-year citation counts (last 5 years)
- References (count)
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51Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.surgery, | 11 |
| abstract_inverted_index.augmented | 141 |
| abstract_inverted_index.chordomas | 30 |
| abstract_inverted_index.efficacy, | 147 |
| abstract_inverted_index.efficacy. | 46 |
| abstract_inverted_index.evaluated | 87 |
| abstract_inverted_index.favorable | 114 |
| abstract_inverted_index.including | 90 |
| abstract_inverted_index.modulated | 113 |
| abstract_inverted_index.molecules | 135 |
| abstract_inverted_index.potential | 25, 63 |
| abstract_inverted_index.prognosis | 14 |
| abstract_inverted_index.prolonged | 104 |
| abstract_inverted_index.providing | 149 |
| abstract_inverted_index.structure | 140 |
| abstract_inverted_index.surfaces, | 126 |
| abstract_inverted_index.CAR-T-cell | 142, 146 |
| abstract_inverted_index.CAR-T/IL-7 | 98 |
| abstract_inverted_index.anti-tumor | 85 |
| abstract_inverted_index.checkpoint | 122 |
| abstract_inverted_index.diminished | 120 |
| abstract_inverted_index.expressing | 79 |
| abstract_inverted_index.expression | 123 |
| abstract_inverted_index.frequently | 8 |
| abstract_inverted_index.identified | 61 |
| abstract_inverted_index.treatment. | 157 |
| abstract_inverted_index.identifying | 32 |
| abstract_inverted_index.sequencing, | 55 |
| abstract_inverted_index.single-cell | 53 |
| abstract_inverted_index.synthesized | 82 |
| abstract_inverted_index.therapeutic | 153 |
| abstract_inverted_index.treatments. | 19 |
| abstract_inverted_index.cytotoxicity | 102 |
| abstract_inverted_index.Additionally, | 111 |
| abstract_inverted_index.incorporation | 132 |
| abstract_inverted_index.potentiators, | 66 |
| abstract_inverted_index.respectively. | 67 |
| abstract_inverted_index.functionality. | 130 |
| abstract_inverted_index.subpopulations | 115 |
| abstract_inverted_index.B7–H3-targeted | 68 |
| abstract_inverted_index.immunotherapeutic | 27 |
| abstract_inverted_index.microenvironmental | 42 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 98 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5199999809265137 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.94332787 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |