Interplay Between Ion Channels and the Wnt/β-Catenin Signaling Pathway in Cancers Article Swipe
Raphael Rapetti‐Mauss
,
Camille Berenguier
,
Benoit Allegrini
,
Olivier Soriani
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2020.525020
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2020.525020
Increasing evidence point out the important roles of ion channels in the physiopathology of cancers, so that these proteins are now considered as potential new therapeutic targets and biomarkers in this disease. Indeed, ion channels have been largely described to participate in many hallmarks of cancers such as migration, invasion, proliferation, angiogenesis, and resistance to apoptosis. At the molecular level, the development of cancers is characterised by alterations in transduction pathways that control cell behaviors. However, the interactions between ion channels and cancer-related signaling pathways are poorly understood so far. Nevertheless, a limited number of reports have recently addressed this important issue, especially regarding the interaction between ion channels and one of the main driving forces for cancer development: the Wnt/β-catenin signaling pathway. In this review, we propose to explore and discuss the current knowledge regarding the interplay between ion channels and the Wnt/β-catenin signaling pathway in cancers.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphar.2020.525020
- https://www.frontiersin.org/articles/10.3389/fphar.2020.525020/pdf
- OA Status
- gold
- Cited By
- 27
- References
- 86
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3090286498
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3090286498Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fphar.2020.525020Digital Object Identifier
- Title
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Interplay Between Ion Channels and the Wnt/β-Catenin Signaling Pathway in CancersWork title
- Type
-
reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-09-29Full publication date if available
- Authors
-
Raphael Rapetti‐Mauss, Camille Berenguier, Benoit Allegrini, Olivier SorianiList of authors in order
- Landing page
-
https://doi.org/10.3389/fphar.2020.525020Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fphar.2020.525020/pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fphar.2020.525020/pdfDirect OA link when available
- Concepts
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Wnt signaling pathway, Ion channel, Signal transduction, Cancer, Angiogenesis, Catenin, Biology, Cancer research, Bioinformatics, Cell biology, Neuroscience, Genetics, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
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27Total citation count in OpenAlex
- Citations by year (recent)
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2025: 7, 2024: 4, 2023: 4, 2022: 6, 2021: 6Per-year citation counts (last 5 years)
- References (count)
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86Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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