Interplay between Lignans and Gut Microbiota: Nutritional, Functional and Methodological Aspects Article Swipe
Simone Baldi
,
Marta Tristán Asensi
,
Marco Pallecchi
,
Francesco Sofi
,
Gianluca Bartolucci
,
Amedeo Amedei
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/molecules28010343
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/molecules28010343
Lignans are non-flavonoid polyphenols present in a wide range of foods frequently consumed in the Western world, such as seeds, vegetables and fruits, and beverages such as coffee, tea and wine. In particular, the human gut microbiota (GM) can convert dietary lignans into biologically active compounds, especially enterolignans (i.e., enterolactone and enterodiol), which play anti-inflammatory and anti-oxidant roles, act as estrogen receptor activators and modulate gene expression and/or enzyme activity. Interestingly, recent evidence documenting those dietary interventions involving foods enriched in lignans have shown beneficial and protective effects on various human pathologies, including colorectal and breast cancer and cardiovascular diseases. However, considering that more factors (e.g., diet, food transit time and intestinal redox state) can modulate the lignans bioactivation by GM, there are usually remarkable inter-individual differences in urine, fecal and blood concentrations of enterolignans; hence, precise and validated analytical methods, especially gas/liquid chromatography coupled to mass spectrometry, are needed for their accurate quantification. Therefore, this review aims to summarize the beneficial roles of enterolignans, their interaction with GM and the new methodological approaches developed for their evaluation in different biological samples, since they could be considered future promising nutraceuticals for the prevention of human chronic disorders.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules28010343
- https://www.mdpi.com/1420-3049/28/1/343/pdf?version=1672557950
- OA Status
- gold
- Cited By
- 43
- References
- 104
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4313473059Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/molecules28010343Digital Object Identifier
- Title
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Interplay between Lignans and Gut Microbiota: Nutritional, Functional and Methodological AspectsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-01-01Full publication date if available
- Authors
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Simone Baldi, Marta Tristán Asensi, Marco Pallecchi, Francesco Sofi, Gianluca Bartolucci, Amedeo AmedeiList of authors in order
- Landing page
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https://doi.org/10.3390/molecules28010343Publisher landing page
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https://www.mdpi.com/1420-3049/28/1/343/pdf?version=1672557950Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1420-3049/28/1/343/pdf?version=1672557950Direct OA link when available
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Enterolactone, Gut flora, Functional food, Nutraceutical, Wine, Polyphenol, Biology, Lignan, Phytoestrogens, Food science, Chemistry, Biotechnology, Biochemistry, Estrogen, Antioxidant, Botany, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
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43Total citation count in OpenAlex
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2025: 23, 2024: 14, 2023: 6Per-year citation counts (last 5 years)
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104Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| cited_by_percentile_year.min | 98 |
| corresponding_author_ids | https://openalex.org/A5082342925 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I4210115393, https://openalex.org/I45084792 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.5199999809265137 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.99148193 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |