Intestinal Microbiome Associated with Efficacy of Atezolizumab and Bevacizumab Therapy for Hepatocellular Carcinoma Article Swipe
Yosuke Inukai
,
Kenta Yamamoto
,
Takashi Honda
,
Shinya Yokoyama
,
Takanori Ito
,
Norihiro Imai
,
Yoji Ishizu
,
Masanao Nakamura
,
Masatoshi Ishigami
,
Hiroki Kawashima
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cancers16091675
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cancers16091675
The combination of atezolizumab and bevacizumab has become the first-line treatment for patients with unresectable hepatocellular carcinoma (HCC). However, no studies have reported on specific intestinal microbiota associated with the efficacy of atezolizumab and bevacizumab. In this study, we analyzed fecal samples collected before treatment to investigate the relationship between the intestinal microbiome and the efficacy of atezolizumab and bevacizumab. A total of 37 patients with advanced HCC who were treated with atezolizumab and bevacizumab were enrolled. Fecal samples were collected from the patients, and they were divided into responder (n = 28) and non-responder (n = 9) groups. We compared the intestinal microbiota of the two groups and analyzed the intestinal bacteria associated with prognosis using QIIME2. The alpha and beta diversities were not significantly different between both groups, and the proportion of microbiota was similar. The relative abundance of Bacteroides stercoris and Parabacteroides merdae was higher in the responder group than in the non-responder group. When the prognosis was analyzed by the presence or absence of those bacteria, patients without both had a significantly poorer prognosis. Differences in intestinal microbiome are involved in the therapeutic effect of atezolizumab and bevacizumab.
Related Topics
Concepts
Atezolizumab
Bevacizumab
Medicine
Hepatocellular carcinoma
Internal medicine
Gastroenterology
Microbiome
Oncology
Bifidobacterium
Probiotic
Cancer
Lactobacillus
Immunotherapy
Pembrolizumab
Chemotherapy
Bacteria
Bioinformatics
Biology
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers16091675
- OA Status
- gold
- Cited By
- 1
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4395683478
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4395683478Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cancers16091675Digital Object Identifier
- Title
-
Intestinal Microbiome Associated with Efficacy of Atezolizumab and Bevacizumab Therapy for Hepatocellular CarcinomaWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-26Full publication date if available
- Authors
-
Yosuke Inukai, Kenta Yamamoto, Takashi Honda, Shinya Yokoyama, Takanori Ito, Norihiro Imai, Yoji Ishizu, Masanao Nakamura, Masatoshi Ishigami, Hiroki KawashimaList of authors in order
- Landing page
-
https://doi.org/10.3390/cancers16091675Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3390/cancers16091675Direct OA link when available
- Concepts
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Atezolizumab, Bevacizumab, Medicine, Hepatocellular carcinoma, Internal medicine, Gastroenterology, Microbiome, Oncology, Bifidobacterium, Probiotic, Cancer, Lactobacillus, Immunotherapy, Pembrolizumab, Chemotherapy, Bacteria, Bioinformatics, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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42Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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