Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress Article Swipe
Meijun Hu
,
Hu L
,
Tao Yang
,
Bowen Zhou
,
Xuanhe Feng
,
Zhipeng Fan
,
Zhaochen Shan
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/antiox13080904
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/antiox13080904
Radiation-induced salivary gland injury (RISGI) is a common complication of radiotherapy in patients with head and neck cancer. Intragland expression of the Sonic Hedgehog (Shh) gene may partially rescue irradiation (IR)-induced hyposalivation by preserving salivary stem/progenitor cells and parasympathetic innervation, maintaining resident macrophages, and maintaining microvascular density. Previous studies have revealed that Ad-Rat Shh transduction through the salivary glands of miniature pigs can ameliorate oxidative stress-induced microvascular dysfunction after radiotherapy. Changes in the parotid salivary flow rate were analyzed, and the parotid tissue was collected at 5 and 20 weeks after IR. Changes in the Hedgehog pathway and vascular function-related markers (vascular endothelial growth factor (VEGF) and CD31) and oxidative stress-related markers were detected via immunohistochemistry, immunofluorescence, and Western blotting. A stable Shh-overexpressing cell line was generated from human umbilical vein endothelial cells (HUVECs) and exposed to 10 Gy X-ray irradiation, after which endothelial cell proliferation, senescence, apoptosis, and vascular function were evaluated. We found that intragland expression of the Shh gene efficiently alleviated IR-induced parotid gland injury in a miniature pig model. Our results indicate that the antioxidative stress and microvascular-protective effects of the Hh pathway are regulated by nuclear factor-erythroid 2-related factor 2 (Nrf2).
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antiox13080904
- OA Status
- gold
- Cited By
- 1
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401028594
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4401028594Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/antiox13080904Digital Object Identifier
- Title
-
Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative StressWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-07-26Full publication date if available
- Authors
-
Meijun Hu, Hu L, Tao Yang, Bowen Zhou, Xuanhe Feng, Zhipeng Fan, Zhaochen ShanList of authors in order
- Landing page
-
https://doi.org/10.3390/antiox13080904Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3390/antiox13080904Direct OA link when available
- Concepts
-
Oxidative stress, Sonic hedgehog, Salivary gland, Vascular endothelial growth factor, CD31, Biology, Cancer research, Angiogenesis, Endocrinology, Internal medicine, Pathology, Medicine, Cell biology, Signal transduction, VEGF receptorsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4401028594 |
|---|---|
| doi | https://doi.org/10.3390/antiox13080904 |
| ids.doi | https://doi.org/10.3390/antiox13080904 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/39199151 |
| ids.openalex | https://openalex.org/W4401028594 |
| fwci | 1.26522389 |
| type | article |
| title | Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress |
| awards[0].id | https://openalex.org/G4213616310 |
| awards[0].funder_id | https://openalex.org/F4320335777 |
| awards[0].display_name | |
| awards[0].funder_award_id | 2022YFC2504201 |
| awards[0].funder_display_name | National Key Research and Development Program of China |
| awards[1].id | https://openalex.org/G4618447349 |
| awards[1].funder_id | https://openalex.org/F4320321001 |
| awards[1].display_name | |
| awards[1].funder_award_id | 82001065 |
| awards[1].funder_display_name | National Natural Science Foundation of China |
| biblio.issue | 8 |
| biblio.volume | 13 |
| biblio.last_page | 904 |
| biblio.first_page | 904 |
| topics[0].id | https://openalex.org/T10307 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9944999814033508 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2733 |
| topics[0].subfield.display_name | Otorhinolaryngology |
| topics[0].display_name | Head and Neck Cancer Studies |
| topics[1].id | https://openalex.org/T12009 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9909999966621399 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Hedgehog Signaling Pathway Studies |
| topics[2].id | https://openalex.org/T11521 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9750000238418579 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2737 |
| topics[2].subfield.display_name | Physiology |
| topics[2].display_name | Salivary Gland Disorders and Functions |
| funders[0].id | https://openalex.org/F4320321001 |
| funders[0].ror | https://ror.org/01h0zpd94 |
| funders[0].display_name | National Natural Science Foundation of China |
| funders[1].id | https://openalex.org/F4320335777 |
| funders[1].ror | |
| funders[1].display_name | National Key Research and Development Program of China |
| is_xpac | False |
| apc_list.value | 2200 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2382 |
| apc_paid.value | 2200 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2382 |
| concepts[0].id | https://openalex.org/C2776151105 |
| concepts[0].level | 2 |
| concepts[0].score | 0.6013926267623901 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q898814 |
| concepts[0].display_name | Oxidative stress |
| concepts[1].id | https://openalex.org/C2776637008 |
| concepts[1].level | 3 |
| concepts[1].score | 0.5257381200790405 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q14860072 |
| concepts[1].display_name | Sonic hedgehog |
| concepts[2].id | https://openalex.org/C2778937882 |
| concepts[2].level | 2 |
| concepts[2].score | 0.4933857023715973 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q134938 |
| concepts[2].display_name | Salivary gland |
| concepts[3].id | https://openalex.org/C2777025900 |
| concepts[3].level | 3 |
| concepts[3].score | 0.4789046049118042 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q29725 |
| concepts[3].display_name | Vascular endothelial growth factor |
| concepts[4].id | https://openalex.org/C2778939058 |
| concepts[4].level | 3 |
| concepts[4].score | 0.46553269028663635 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q4046167 |
| concepts[4].display_name | CD31 |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.4654883146286011 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C502942594 |
| concepts[6].level | 1 |
| concepts[6].score | 0.456144779920578 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[6].display_name | Cancer research |
| concepts[7].id | https://openalex.org/C2780394083 |
| concepts[7].level | 2 |
| concepts[7].score | 0.42885488271713257 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q539568 |
| concepts[7].display_name | Angiogenesis |
| concepts[8].id | https://openalex.org/C134018914 |
| concepts[8].level | 1 |
| concepts[8].score | 0.4274674355983734 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[8].display_name | Endocrinology |
| concepts[9].id | https://openalex.org/C126322002 |
| concepts[9].level | 1 |
| concepts[9].score | 0.37876760959625244 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[9].display_name | Internal medicine |
| concepts[10].id | https://openalex.org/C142724271 |
| concepts[10].level | 1 |
| concepts[10].score | 0.3778145909309387 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[10].display_name | Pathology |
| concepts[11].id | https://openalex.org/C71924100 |
| concepts[11].level | 0 |
| concepts[11].score | 0.29494208097457886 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[11].display_name | Medicine |
| concepts[12].id | https://openalex.org/C95444343 |
| concepts[12].level | 1 |
| concepts[12].score | 0.25643157958984375 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[12].display_name | Cell biology |
| concepts[13].id | https://openalex.org/C62478195 |
| concepts[13].level | 2 |
| concepts[13].score | 0.18299472332000732 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q828130 |
| concepts[13].display_name | Signal transduction |
| concepts[14].id | https://openalex.org/C167734588 |
| concepts[14].level | 2 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q4356503 |
| concepts[14].display_name | VEGF receptors |
| keywords[0].id | https://openalex.org/keywords/oxidative-stress |
| keywords[0].score | 0.6013926267623901 |
| keywords[0].display_name | Oxidative stress |
| keywords[1].id | https://openalex.org/keywords/sonic-hedgehog |
| keywords[1].score | 0.5257381200790405 |
| keywords[1].display_name | Sonic hedgehog |
| keywords[2].id | https://openalex.org/keywords/salivary-gland |
| keywords[2].score | 0.4933857023715973 |
| keywords[2].display_name | Salivary gland |
| keywords[3].id | https://openalex.org/keywords/vascular-endothelial-growth-factor |
| keywords[3].score | 0.4789046049118042 |
| keywords[3].display_name | Vascular endothelial growth factor |
| keywords[4].id | https://openalex.org/keywords/cd31 |
| keywords[4].score | 0.46553269028663635 |
| keywords[4].display_name | CD31 |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.4654883146286011 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/cancer-research |
| keywords[6].score | 0.456144779920578 |
| keywords[6].display_name | Cancer research |
| keywords[7].id | https://openalex.org/keywords/angiogenesis |
| keywords[7].score | 0.42885488271713257 |
| keywords[7].display_name | Angiogenesis |
| keywords[8].id | https://openalex.org/keywords/endocrinology |
| keywords[8].score | 0.4274674355983734 |
| keywords[8].display_name | Endocrinology |
| keywords[9].id | https://openalex.org/keywords/internal-medicine |
| keywords[9].score | 0.37876760959625244 |
| keywords[9].display_name | Internal medicine |
| keywords[10].id | https://openalex.org/keywords/pathology |
| keywords[10].score | 0.3778145909309387 |
| keywords[10].display_name | Pathology |
| keywords[11].id | https://openalex.org/keywords/medicine |
| keywords[11].score | 0.29494208097457886 |
| keywords[11].display_name | Medicine |
| keywords[12].id | https://openalex.org/keywords/cell-biology |
| keywords[12].score | 0.25643157958984375 |
| keywords[12].display_name | Cell biology |
| keywords[13].id | https://openalex.org/keywords/signal-transduction |
| keywords[13].score | 0.18299472332000732 |
| keywords[13].display_name | Signal transduction |
| language | en |
| locations[0].id | doi:10.3390/antiox13080904 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2737566431 |
| locations[0].source.issn | 2076-3921 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2076-3921 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Antioxidants |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Antioxidants |
| locations[0].landing_page_url | https://doi.org/10.3390/antiox13080904 |
| locations[1].id | pmid:39199151 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Antioxidants (Basel, Switzerland) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/39199151 |
| locations[2].id | pmh:oai:doaj.org/article:f9ad5fc3189344438309bb8a4fe3d209 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Antioxidants, Vol 13, Iss 8, p 904 (2024) |
| locations[2].landing_page_url | https://doaj.org/article/f9ad5fc3189344438309bb8a4fe3d209 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:11351712 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Antioxidants (Basel) |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11351712 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5102435148 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Meijun Hu |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I183519381 |
| authorships[0].affiliations[0].raw_affiliation_string | Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing 100050, China |
| authorships[0].institutions[0].id | https://openalex.org/I183519381 |
| authorships[0].institutions[0].ror | https://ror.org/013xs5b60 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I183519381 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Capital Medical University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Meijun Hu |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing 100050, China |
| authorships[1].author.id | https://openalex.org/A5101462142 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-3955-7530 |
| authorships[1].author.display_name | Hu L |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I183519381 |
| authorships[1].affiliations[0].raw_affiliation_string | Outpatient Department of Oral and Maxillofacial Surgery, School of Stomatology, Capital Medical University, Beijing 100050, China |
| authorships[1].institutions[0].id | https://openalex.org/I183519381 |
| authorships[1].institutions[0].ror | https://ror.org/013xs5b60 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I183519381 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Capital Medical University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Liang Hu |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Outpatient Department of Oral and Maxillofacial Surgery, School of Stomatology, Capital Medical University, Beijing 100050, China |
| authorships[2].author.id | https://openalex.org/A5108060262 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-3127-3944 |
| authorships[2].author.display_name | Tao Yang |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I183519381 |
| authorships[2].affiliations[0].raw_affiliation_string | Outpatient Department of Oral and Maxillofacial Surgery, School of Stomatology, Capital Medical University, Beijing 100050, China |
| authorships[2].institutions[0].id | https://openalex.org/I183519381 |
| authorships[2].institutions[0].ror | https://ror.org/013xs5b60 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I183519381 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Capital Medical University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Tao Yang |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Outpatient Department of Oral and Maxillofacial Surgery, School of Stomatology, Capital Medical University, Beijing 100050, China |
| authorships[3].author.id | https://openalex.org/A5107808331 |
| authorships[3].author.orcid | https://orcid.org/0009-0004-3414-6267 |
| authorships[3].author.display_name | Bowen Zhou |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I183519381 |
| authorships[3].affiliations[0].raw_affiliation_string | Outpatient Department of Oral and Maxillofacial Surgery, School of Stomatology, Capital Medical University, Beijing 100050, China |
| authorships[3].institutions[0].id | https://openalex.org/I183519381 |
| authorships[3].institutions[0].ror | https://ror.org/013xs5b60 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I183519381 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Capital Medical University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Bowen Zhou |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Outpatient Department of Oral and Maxillofacial Surgery, School of Stomatology, Capital Medical University, Beijing 100050, China |
| authorships[4].author.id | https://openalex.org/A5044450414 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Xuanhe Feng |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I183519381 |
| authorships[4].affiliations[0].raw_affiliation_string | Outpatient Department of Oral and Maxillofacial Surgery, School of Stomatology, Capital Medical University, Beijing 100050, China |
| authorships[4].institutions[0].id | https://openalex.org/I183519381 |
| authorships[4].institutions[0].ror | https://ror.org/013xs5b60 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I183519381 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Capital Medical University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Xuanhe Feng |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Outpatient Department of Oral and Maxillofacial Surgery, School of Stomatology, Capital Medical University, Beijing 100050, China |
| authorships[5].author.id | https://openalex.org/A5100680746 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-0629-3476 |
| authorships[5].author.display_name | Zhipeng Fan |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I183519381 |
| authorships[5].affiliations[0].raw_affiliation_string | Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing 100050, China |
| authorships[5].institutions[0].id | https://openalex.org/I183519381 |
| authorships[5].institutions[0].ror | https://ror.org/013xs5b60 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I183519381 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Capital Medical University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Zhipeng Fan |
| authorships[5].is_corresponding | True |
| authorships[5].raw_affiliation_strings | Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing 100050, China |
| authorships[6].author.id | https://openalex.org/A5100325425 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-3990-9011 |
| authorships[6].author.display_name | Zhaochen Shan |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I183519381 |
| authorships[6].affiliations[0].raw_affiliation_string | Outpatient Department of Oral and Maxillofacial Surgery, School of Stomatology, Capital Medical University, Beijing 100050, China |
| authorships[6].institutions[0].id | https://openalex.org/I183519381 |
| authorships[6].institutions[0].ror | https://ror.org/013xs5b60 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I183519381 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Capital Medical University |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Zhaochen Shan |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Outpatient Department of Oral and Maxillofacial Surgery, School of Stomatology, Capital Medical University, Beijing 100050, China |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.3390/antiox13080904 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10307 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9944999814033508 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2733 |
| primary_topic.subfield.display_name | Otorhinolaryngology |
| primary_topic.display_name | Head and Neck Cancer Studies |
| related_works | https://openalex.org/W2075734225, https://openalex.org/W2042474810, https://openalex.org/W4361241331, https://openalex.org/W2561802298, https://openalex.org/W2111256185, https://openalex.org/W2070894792, https://openalex.org/W2322422918, https://openalex.org/W3036594663, https://openalex.org/W1980885235, https://openalex.org/W2053044654 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3390/antiox13080904 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2737566431 |
| best_oa_location.source.issn | 2076-3921 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2076-3921 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Antioxidants |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Antioxidants |
| best_oa_location.landing_page_url | https://doi.org/10.3390/antiox13080904 |
| primary_location.id | doi:10.3390/antiox13080904 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2737566431 |
| primary_location.source.issn | 2076-3921 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2076-3921 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Antioxidants |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Antioxidants |
| primary_location.landing_page_url | https://doi.org/10.3390/antiox13080904 |
| publication_date | 2024-07-26 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W3119005666, https://openalex.org/W4200247705, https://openalex.org/W2301380784, https://openalex.org/W4388835263, https://openalex.org/W2113092282, https://openalex.org/W2119727448, https://openalex.org/W3208030216, https://openalex.org/W2086918412, https://openalex.org/W4306736855, https://openalex.org/W2040743475, https://openalex.org/W2791177725, https://openalex.org/W4392195466, https://openalex.org/W4392455379, https://openalex.org/W4390843884, https://openalex.org/W3112901101, https://openalex.org/W2167089050, https://openalex.org/W2885579791, https://openalex.org/W2625199396, https://openalex.org/W3125143928, https://openalex.org/W2604698549, https://openalex.org/W2153744421, https://openalex.org/W2760053683, https://openalex.org/W1498587827, https://openalex.org/W2032816864, https://openalex.org/W3101977567, https://openalex.org/W4386898568, https://openalex.org/W4391581546, https://openalex.org/W4389507492, https://openalex.org/W3095101609, https://openalex.org/W4392796825, https://openalex.org/W4390972307, https://openalex.org/W4392799063, https://openalex.org/W4392915892, https://openalex.org/W4379598398, https://openalex.org/W4307966121, https://openalex.org/W4382776774, https://openalex.org/W2801257143, https://openalex.org/W2233853789, https://openalex.org/W3213957383, https://openalex.org/W4390485145, https://openalex.org/W2463833592, https://openalex.org/W2889239000, https://openalex.org/W4283645191, https://openalex.org/W2087760897, https://openalex.org/W2108836663, https://openalex.org/W2891221267, https://openalex.org/W4210670182, https://openalex.org/W4283585817 |
| referenced_works_count | 48 |
| abstract_inverted_index.2 | 194 |
| abstract_inverted_index.5 | 86 |
| abstract_inverted_index.A | 120 |
| abstract_inverted_index.a | 6, 169 |
| abstract_inverted_index.10 | 137 |
| abstract_inverted_index.20 | 88 |
| abstract_inverted_index.Gy | 138 |
| abstract_inverted_index.Hh | 185 |
| abstract_inverted_index.We | 153 |
| abstract_inverted_index.at | 85 |
| abstract_inverted_index.by | 32, 189 |
| abstract_inverted_index.in | 11, 71, 93, 168 |
| abstract_inverted_index.is | 5 |
| abstract_inverted_index.of | 9, 20, 59, 158, 183 |
| abstract_inverted_index.to | 136 |
| abstract_inverted_index.IR. | 91 |
| abstract_inverted_index.Our | 173 |
| abstract_inverted_index.Shh | 53, 160 |
| abstract_inverted_index.and | 15, 37, 43, 79, 87, 97, 106, 108, 117, 134, 148, 180 |
| abstract_inverted_index.are | 187 |
| abstract_inverted_index.can | 62 |
| abstract_inverted_index.may | 26 |
| abstract_inverted_index.pig | 171 |
| abstract_inverted_index.the | 21, 56, 72, 80, 94, 159, 177, 184 |
| abstract_inverted_index.via | 114 |
| abstract_inverted_index.was | 83, 125 |
| abstract_inverted_index.cell | 123, 144 |
| abstract_inverted_index.flow | 75 |
| abstract_inverted_index.from | 127 |
| abstract_inverted_index.gene | 25, 161 |
| abstract_inverted_index.have | 49 |
| abstract_inverted_index.head | 14 |
| abstract_inverted_index.line | 124 |
| abstract_inverted_index.neck | 16 |
| abstract_inverted_index.pigs | 61 |
| abstract_inverted_index.rate | 76 |
| abstract_inverted_index.that | 51, 155, 176 |
| abstract_inverted_index.vein | 130 |
| abstract_inverted_index.were | 77, 112, 151 |
| abstract_inverted_index.with | 13 |
| abstract_inverted_index.(Shh) | 24 |
| abstract_inverted_index.CD31) | 107 |
| abstract_inverted_index.Sonic | 22 |
| abstract_inverted_index.X-ray | 139 |
| abstract_inverted_index.after | 68, 90, 141 |
| abstract_inverted_index.cells | 36, 132 |
| abstract_inverted_index.found | 154 |
| abstract_inverted_index.gland | 2, 166 |
| abstract_inverted_index.human | 128 |
| abstract_inverted_index.weeks | 89 |
| abstract_inverted_index.which | 142 |
| abstract_inverted_index.(VEGF) | 105 |
| abstract_inverted_index.Ad-Rat | 52 |
| abstract_inverted_index.common | 7 |
| abstract_inverted_index.factor | 104, 193 |
| abstract_inverted_index.glands | 58 |
| abstract_inverted_index.growth | 103 |
| abstract_inverted_index.injury | 3, 167 |
| abstract_inverted_index.model. | 172 |
| abstract_inverted_index.rescue | 28 |
| abstract_inverted_index.stable | 121 |
| abstract_inverted_index.stress | 179 |
| abstract_inverted_index.tissue | 82 |
| abstract_inverted_index.(Nrf2). | 195 |
| abstract_inverted_index.(RISGI) | 4 |
| abstract_inverted_index.Changes | 70, 92 |
| abstract_inverted_index.Western | 118 |
| abstract_inverted_index.cancer. | 17 |
| abstract_inverted_index.effects | 182 |
| abstract_inverted_index.exposed | 135 |
| abstract_inverted_index.markers | 100, 111 |
| abstract_inverted_index.nuclear | 190 |
| abstract_inverted_index.parotid | 73, 81, 165 |
| abstract_inverted_index.pathway | 96, 186 |
| abstract_inverted_index.results | 174 |
| abstract_inverted_index.studies | 48 |
| abstract_inverted_index.through | 55 |
| abstract_inverted_index.(HUVECs) | 133 |
| abstract_inverted_index.Hedgehog | 23, 95 |
| abstract_inverted_index.Previous | 47 |
| abstract_inverted_index.density. | 46 |
| abstract_inverted_index.detected | 113 |
| abstract_inverted_index.function | 150 |
| abstract_inverted_index.indicate | 175 |
| abstract_inverted_index.patients | 12 |
| abstract_inverted_index.resident | 41 |
| abstract_inverted_index.revealed | 50 |
| abstract_inverted_index.salivary | 1, 34, 57, 74 |
| abstract_inverted_index.vascular | 98, 149 |
| abstract_inverted_index.(vascular | 101 |
| abstract_inverted_index.2-related | 192 |
| abstract_inverted_index.analyzed, | 78 |
| abstract_inverted_index.blotting. | 119 |
| abstract_inverted_index.collected | 84 |
| abstract_inverted_index.generated | 126 |
| abstract_inverted_index.miniature | 60, 170 |
| abstract_inverted_index.oxidative | 64, 109 |
| abstract_inverted_index.partially | 27 |
| abstract_inverted_index.regulated | 188 |
| abstract_inverted_index.umbilical | 129 |
| abstract_inverted_index.IR-induced | 164 |
| abstract_inverted_index.Intragland | 18 |
| abstract_inverted_index.alleviated | 163 |
| abstract_inverted_index.ameliorate | 63 |
| abstract_inverted_index.apoptosis, | 147 |
| abstract_inverted_index.evaluated. | 152 |
| abstract_inverted_index.expression | 19, 157 |
| abstract_inverted_index.intragland | 156 |
| abstract_inverted_index.preserving | 33 |
| abstract_inverted_index.dysfunction | 67 |
| abstract_inverted_index.efficiently | 162 |
| abstract_inverted_index.endothelial | 102, 131, 143 |
| abstract_inverted_index.irradiation | 29 |
| abstract_inverted_index.maintaining | 40, 44 |
| abstract_inverted_index.senescence, | 146 |
| abstract_inverted_index.(IR)-induced | 30 |
| abstract_inverted_index.complication | 8 |
| abstract_inverted_index.innervation, | 39 |
| abstract_inverted_index.irradiation, | 140 |
| abstract_inverted_index.macrophages, | 42 |
| abstract_inverted_index.radiotherapy | 10 |
| abstract_inverted_index.transduction | 54 |
| abstract_inverted_index.antioxidative | 178 |
| abstract_inverted_index.microvascular | 45, 66 |
| abstract_inverted_index.radiotherapy. | 69 |
| abstract_inverted_index.hyposalivation | 31 |
| abstract_inverted_index.proliferation, | 145 |
| abstract_inverted_index.stress-induced | 65 |
| abstract_inverted_index.stress-related | 110 |
| abstract_inverted_index.parasympathetic | 38 |
| abstract_inverted_index.stem/progenitor | 35 |
| abstract_inverted_index.factor-erythroid | 191 |
| abstract_inverted_index.function-related | 99 |
| abstract_inverted_index.Radiation-induced | 0 |
| abstract_inverted_index.Shh-overexpressing | 122 |
| abstract_inverted_index.immunofluorescence, | 116 |
| abstract_inverted_index.immunohistochemistry, | 115 |
| abstract_inverted_index.microvascular-protective | 181 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5100680746, https://openalex.org/A5100325425 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I183519381 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/14 |
| sustainable_development_goals[0].score | 0.5 |
| sustainable_development_goals[0].display_name | Life below water |
| citation_normalized_percentile.value | 0.7103582 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |