Intranasal Administration of Melanin-Concentrating Hormone Reduces Stress-Induced Anxiety- and Depressive-Like Behaviors in Rodents Article Swipe
Ju‐Young Oh
,
Quan Feng Liu
,
Hua Cai
,
Ha Jin Jeong
,
Jae‐Hwan Jang
,
Songhee Jeon
,
Hi‐Joon Park
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.5607/en20024
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.5607/en20024
Major depressive disorder is a complex neuropsychiatric disorder with few treatment options. Non-targeted antidepressants have low efficacy and can induce series of side effects. While a neuropeptide, melanin-concentrating hormone (MCH), is known to exhibit regulator of affective state, no study to date has assessed the anti-depressive effects of MCH in a stress-induced depression model. This study aimed to evaluate the pharmacological effects of intranasal administration of MCH on depression-related behavior in stressed rats and mice. Using a number of behavioral tests, we found that MCH treatment significantly decreased anxiety- and depressive-like behaviors induced by stress. Notably, the effects of MCH were equivalent to those of fluoxetine. MCH treatment also restored the activity of the mammalian target of rapamycin (mTOR) signaling pathway and normalized the levels of synaptic proteins, including postsynaptic density 95, glutamate receptor 1, and synapsin 1, which were all downregulated by stress. Interestingly, the protective effects of MCH were blocked by the mTOR inhibitor, rapamycin. These results suggest that MCH exhibits antidepressant properties by modulating the mTOR pathway. Altogether, this study provides an insight into the molecular mechanisms involved in the antidepressant-like effects of MCH, thereby paving the way for the future clinical application of MCH.
Related Topics
Concepts
Melanin-concentrating hormone
Antidepressant
PI3K/AKT/mTOR pathway
Synapsin I
Nasal administration
Fluoxetine
Medicine
Anxiety
Major depressive disorder
Neuropeptide
Pharmacology
Endocrinology
Internal medicine
Receptor
Signal transduction
Amygdala
Biology
Psychiatry
Serotonin
Genetics
Biochemistry
Membrane
Vesicle
Synaptic vesicle
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.5607/en20024
- https://www.en-journal.org/journal/download_pdf.php?uid=542
- OA Status
- diamond
- Cited By
- 31
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3114537302
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3114537302Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.5607/en20024Digital Object Identifier
- Title
-
Intranasal Administration of Melanin-Concentrating Hormone Reduces Stress-Induced Anxiety- and Depressive-Like Behaviors in RodentsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-12-29Full publication date if available
- Authors
-
Ju‐Young Oh, Quan Feng Liu, Hua Cai, Ha Jin Jeong, Jae‐Hwan Jang, Songhee Jeon, Hi‐Joon ParkList of authors in order
- Landing page
-
https://doi.org/10.5607/en20024Publisher landing page
- PDF URL
-
https://www.en-journal.org/journal/download_pdf.php?uid=542Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://www.en-journal.org/journal/download_pdf.php?uid=542Direct OA link when available
- Concepts
-
Melanin-concentrating hormone, Antidepressant, PI3K/AKT/mTOR pathway, Synapsin I, Nasal administration, Fluoxetine, Medicine, Anxiety, Major depressive disorder, Neuropeptide, Pharmacology, Endocrinology, Internal medicine, Receptor, Signal transduction, Amygdala, Biology, Psychiatry, Serotonin, Genetics, Biochemistry, Membrane, Vesicle, Synaptic vesicleTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
31Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 14, 2023: 3, 2022: 8, 2021: 4Per-year citation counts (last 5 years)
- References (count)
-
56Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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