Intranasal fentanyl and discharge from the emergency department among children with sickle cell disease and vaso‐occlusive pain: A multicenter pediatric emergency medicine perspective Article Swipe
Chris A. Rees
,
David C. Brousseau
,
Fahd A. Ahmad
,
Jonathan E. Bennett
,
Seema Bhatt
,
Amanda Bogie
,
Kathleen Brown
,
T. Charles Casper
,
Laura L. Chapman
,
Corrie E. Chumpitazi
,
Daniel M. Cohen
,
Carlton Dampier
,
Angela M. Ellison
,
Hartmut Grasemann
,
Dunia Hatabah
,
Robert W. Hickey
,
Lewis L. Hsu
,
Nitya Bakshi
,
Sara Leibovich
,
Prabhumallikarjun Patil
,
Elizabeth C. Powell
,
Rachel Richards
,
Syana Sarnaik
,
Debra L. Weiner
,
Claudia R. Morris
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/ajh.26837
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/ajh.26837
Children with sickle cell disease (SCD) commonly experience vaso‐occlusive pain episodes (VOE) due to sickling of erythrocytes, which often requires care in the emergency department. Our objective was to assess the use and impact of intranasal fentanyl for the treatment of children with SCD‐VOE on discharge from the emergency department in a multicenter study. We conducted a cross‐sectional study at 20 academic pediatric emergency departments in the United States and Canada. We used logistic regression to test bivariable and multivariable associations between the outcome of discharge from the emergency department and candidate variables theoretically associated with discharge. The study included 400 patients; 215 (54%) were female. The median age was 14.6 (interquartile range 9.8, 17.6) years. Nineteen percent ( n = 75) received intranasal fentanyl in the emergency department. Children who received intranasal fentanyl had nearly nine‐fold greater adjusted odds of discharge from the emergency department compared to those who did not (adjusted odds ratio 8.99, 95% CI 2.81–30.56, p < .001). The rapid onset of action and ease of delivery without intravenous access offered by intranasal fentanyl make it a feasible initial parenteral analgesic in the treatment of children with SCD presenting with VOE in the acute‐care setting. Further study is needed to determine potential causality of the association between intranasal fentanyl and discharge from the emergency department observed in this multicenter study.
Related Topics
Concepts
Medicine
Emergency department
Interquartile range
Vaso-occlusive crisis
Fentanyl
Acute chest syndrome
Odds ratio
Emergency medicine
Pediatric emergency medicine
Sickle cell anemia
Pediatrics
Anesthesia
Internal medicine
Disease
Emergency physician
Psychiatry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/ajh.26837
- OA Status
- green
- Cited By
- 25
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4313645529
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4313645529Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/ajh.26837Digital Object Identifier
- Title
-
Intranasal fentanyl and discharge from the emergency department among children with sickle cell disease and vaso‐occlusive pain: A multicenter pediatric emergency medicine perspectiveWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-06Full publication date if available
- Authors
-
Chris A. Rees, David C. Brousseau, Fahd A. Ahmad, Jonathan E. Bennett, Seema Bhatt, Amanda Bogie, Kathleen Brown, T. Charles Casper, Laura L. Chapman, Corrie E. Chumpitazi, Daniel M. Cohen, Carlton Dampier, Angela M. Ellison, Hartmut Grasemann, Dunia Hatabah, Robert W. Hickey, Lewis L. Hsu, Nitya Bakshi, Sara Leibovich, Prabhumallikarjun Patil, Elizabeth C. Powell, Rachel Richards, Syana Sarnaik, Debra L. Weiner, Claudia R. MorrisList of authors in order
- Landing page
-
https://doi.org/10.1002/ajh.26837Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://pmc.ncbi.nlm.nih.gov/articles/PMC10023395/pdf/nihms-1862566.pdfDirect OA link when available
- Concepts
-
Medicine, Emergency department, Interquartile range, Vaso-occlusive crisis, Fentanyl, Acute chest syndrome, Odds ratio, Emergency medicine, Pediatric emergency medicine, Sickle cell anemia, Pediatrics, Anesthesia, Internal medicine, Disease, Emergency physician, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
25Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 8, 2024: 8, 2023: 9Per-year citation counts (last 5 years)
- References (count)
-
29Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.percent | 118 |
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| corresponding_author_ids | https://openalex.org/A5041675077 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 25 |
| corresponding_institution_ids | https://openalex.org/I150468666, https://openalex.org/I4210146983 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.800000011920929 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.97916809 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |