Intravenous Fluid Administration and the Coagulation System Article Swipe
Corrin J. Boyd
,
Benjamin M. Brainard
,
Lisa Smart
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fvets.2021.662504
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fvets.2021.662504
Intravenous fluid administration in veterinary patients can alter coagulation function by several mechanisms. Both crystalloid and colloid fluids cause hemodilution, reducing platelet count and plasma coagulation protein concentrations. Hemodilution is associated with a hypercoagulable effect at low dilutions and a hypocoagulable effect at higher dilutions. Composition of crystalloid fluids likely has a minor effect, primarily dependent on fluid ion composition. Hypertonic crystalloids may also cause hypocoagulability. Colloids, both synthetic and natural, can cause hypocoagulability by several mechanisms beyond the effects of hemodilution. These include impaired platelet function, decreased plasma coagulation factor activity, impaired fibrin formation and crosslinking, and accelerated fibrinolysis. The vast majority of the veterinary literature investigates the hypocoagulable effects of hydroxyethyl starch–containing fluids using in vitro , experimental, and clinical studies. However, results are inconsistent, likely due to the varying doses and physicochemical properties of the specific fluid products across studies. In addition, some evidence exists for hypocoagulable effects of gelatin and albumin solutions. There is also evidence that these colloids increase the risk of clinical bleeding in people. Limitations of the veterinary evidence for the hypocoagulable effects of colloid fluids include a predominance of in vitro studies and in vivo studies using healthy subjects, which exclude the interaction of the effects of illness. Therefore, clinical relevance of these effects, especially for low-molecular-weight hydroxyethyl starch, is unknown. Firm recommendations about the most appropriate fluid to use in clinical scenarios cannot be made, although it is prudent to limit the dose of synthetic colloid in at-risk patients. Clinicians should closely monitor relevant coagulation assays and for evidence of hemorrhage in at-risk patients receiving any type of fluid therapy, especially in large volumes.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fvets.2021.662504
- https://www.frontiersin.org/articles/10.3389/fvets.2021.662504/pdf
- OA Status
- gold
- Cited By
- 16
- References
- 152
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3155515751
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3155515751Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fvets.2021.662504Digital Object Identifier
- Title
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Intravenous Fluid Administration and the Coagulation SystemWork title
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-04-15Full publication date if available
- Authors
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Corrin J. Boyd, Benjamin M. Brainard, Lisa SmartList of authors in order
- Landing page
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https://doi.org/10.3389/fvets.2021.662504Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fvets.2021.662504/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fvets.2021.662504/pdfDirect OA link when available
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Administration (probate law), Coagulation, Coagulation system, Medicine, Pharmacology, Political science, Internal medicine, LawTop concepts (fields/topics) attached by OpenAlex
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16Total citation count in OpenAlex
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2025: 7, 2024: 3, 2023: 2, 2022: 4Per-year citation counts (last 5 years)
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152Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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