Intrinsic and extrinsic factors that influence ovarian environment and efficiency of reproduction in cattle Article Swipe
YOU?
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· 2016
· Open Access
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· DOI: https://doi.org/10.21451/1984-3143-ar907
All the somatic cells composing a mammalian organism are genetically identical and contain the same DNA sequence.Nevertheless, they are able to adopt a distinct commitment, differentiate in a tissue specific way and respond to developmental cues, acquiring a terminal phenotype.At the end of the differentiation process, each cell is highly specialized and committed to a distinct determined fate.This is possible thanks to tissue-specific gene expression, timely regulated by epigenetic modifications, that gradually limit cell potency to a more restricted phenotype-related expression pattern.Complex chemical modifications of DNA, RNA and associated proteins, that determine activation or silencing of certain genes are responsible for the 'epigenetic control' that triggers the restriction of cell pluripotency, with the acquisition of the phenotypic definition and the preservation of its stability during subsequent cell divisions.The process is however reversible and may be modified by biochemical and biological manipulation, leading to the reactivation of hypermethylated pluripotency genes and inducing cells to transit from a terminally committed state to a higher plasticity one.These epigenetic regulatory mechanisms play a key role in embryonic development since they drive phenotype definition and tissue differentiation.At the same time, they are crucial for a better understanding of pluripotency regulation and restriction, stem cell biology and tissue repair process.
Related Topics
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.21451/1984-3143-ar907
- https://doi.org/10.21451/1984-3143-ar907
- OA Status
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- OpenAlex ID
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Raw OpenAlex JSON
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https://doi.org/10.21451/1984-3143-ar907Digital Object Identifier
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Intrinsic and extrinsic factors that influence ovarian environment and efficiency of reproduction in cattleWork title
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articleOpenAlex work type
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enPrimary language
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2016Year of publication
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2016-11-17Full publication date if available
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Pietro Sampaio Baruselli, E. O. S. Batista, Leandro M. Vieira, J. N. S. Sales, Lindsay Unno Gimenes, R. M. FerreiraList of authors in order
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https://doi.org/10.21451/1984-3143-ar907Publisher landing page
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https://doi.org/10.21451/1984-3143-ar907Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.21451/1984-3143-ar907Direct OA link when available
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Reproduction, Biology, Internal medicine, Endocrinology, Medicine, EcologyTop concepts (fields/topics) attached by OpenAlex
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10Total citation count in OpenAlex
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2025: 2, 2023: 3, 2020: 2, 2018: 2, 2017: 1Per-year citation counts (last 5 years)
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82Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2020501781, https://openalex.org/W1994723896, https://openalex.org/W1994344123, https://openalex.org/W2292461067, https://openalex.org/W2033500695, https://openalex.org/W2086948497, https://openalex.org/W2022507430, https://openalex.org/W1967835379, https://openalex.org/W6679423453, https://openalex.org/W2123371822, https://openalex.org/W2007497552, https://openalex.org/W2101569447, https://openalex.org/W1998330230, https://openalex.org/W2106485710, https://openalex.org/W2139697647, https://openalex.org/W1969015262, https://openalex.org/W1539368821, https://openalex.org/W2083462941, https://openalex.org/W1994855470, https://openalex.org/W2053911973, https://openalex.org/W2032570745, https://openalex.org/W2032058920, https://openalex.org/W2014034815, https://openalex.org/W2002943691, https://openalex.org/W1969941116, https://openalex.org/W2144632590, https://openalex.org/W2050689355, https://openalex.org/W2017394727, https://openalex.org/W2125987139, https://openalex.org/W2117002777, https://openalex.org/W2078609519, https://openalex.org/W6649466680, https://openalex.org/W2116429223, https://openalex.org/W2152483372, https://openalex.org/W1991037959, https://openalex.org/W2037710811, https://openalex.org/W1994202713, https://openalex.org/W2105044270, https://openalex.org/W2054771086, https://openalex.org/W2748091333, https://openalex.org/W4242621632, https://openalex.org/W2129572589, https://openalex.org/W2130907138, https://openalex.org/W1997198166, https://openalex.org/W2591019588, https://openalex.org/W2318391726, https://openalex.org/W2003750107, https://openalex.org/W2062210630, https://openalex.org/W202113929, https://openalex.org/W2063607020, https://openalex.org/W1997505405, https://openalex.org/W1996240496, https://openalex.org/W2170395027, https://openalex.org/W2047015004, https://openalex.org/W2258576233, https://openalex.org/W2027833338, https://openalex.org/W2087857517, https://openalex.org/W2132180558, https://openalex.org/W2072239613, https://openalex.org/W2339857072, https://openalex.org/W1993287022, https://openalex.org/W3137689183, https://openalex.org/W2053418565, https://openalex.org/W2124572856, https://openalex.org/W2163824813, https://openalex.org/W2098597036, https://openalex.org/W1964355013, https://openalex.org/W2170653904, https://openalex.org/W2072561392, https://openalex.org/W2093888082, https://openalex.org/W1996676239, https://openalex.org/W2161435642, https://openalex.org/W3116036139, https://openalex.org/W2132489991, https://openalex.org/W2338309018, https://openalex.org/W1990540561, https://openalex.org/W1964224339, https://openalex.org/W2148070806, https://openalex.org/W2115071107, https://openalex.org/W2158979552, https://openalex.org/W2063705548, https://openalex.org/W1994440387 |
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