Intrinsically Disordered Regions Define Unique Protein Interaction Networks in CHD Family Remodelers Article Swipe
Mehdi Sharifi Tabar
,
Chirag Parsania
,
Caroline Giardina
,
Yue Feng
,
Alex C. H. Wong
,
Cynthia Metierre
,
Rajini Nagarajah
,
Bijay Dhungel
,
John E.J. Rasko
,
Charles G. Bailey
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.25.609601
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.25.609601
Chromodomain helicase DNA-binding (CHD1-9) enzymes reposition nucleosomal DNA for transcription, recombination, and replication. They possess highly conserved ATPase domains flanked by poorly characterised N- and C-termini, which are enriched with intrinsically disordered regions (IDRs) and short aggregation-prone regions (APRs). The roles of IDRs and APRs in CHD function has remained elusive. Here, by integrating proteomics and AlphaFold Multimer analysis, we defined the protein-protein interaction (PPI) networks within the N- and C-termini of all CHDs. We generated a comprehensive map of CHD1-9-specific binding proteins, revealing dozens of novel interactions with transcription regulators. We identified APR regions that contribute to PPI formation and demonstrated that a highly conserved APR within the C-terminus of CHD4 is critical for its interaction with the nucleosome remodeling and deacetylase (NuRD), as well as the CHD, ADNP, and HP1 (ChAHP) complexes. Further analysis unravels a regulatory role for the CHD4 APR in gene transcription during erythrocyte formation. Our results emphasize that the N- and C-termini of CHD chromatin remodelers establish PPI networks that drive unique transcriptional programs.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.08.25.609601
- https://www.biorxiv.org/content/biorxiv/early/2024/08/25/2024.08.25.609601.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 44
- Related Works
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- OpenAlex ID
- https://openalex.org/W4401866980
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https://doi.org/10.1101/2024.08.25.609601Digital Object Identifier
- Title
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Intrinsically Disordered Regions Define Unique Protein Interaction Networks in CHD Family RemodelersWork title
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-08-25Full publication date if available
- Authors
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Mehdi Sharifi Tabar, Chirag Parsania, Caroline Giardina, Yue Feng, Alex C. H. Wong, Cynthia Metierre, Rajini Nagarajah, Bijay Dhungel, John E.J. Rasko, Charles G. BaileyList of authors in order
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https://doi.org/10.1101/2024.08.25.609601Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2024/08/25/2024.08.25.609601.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2024/08/25/2024.08.25.609601.full.pdfDirect OA link when available
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10Other works algorithmically related by OpenAlex
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| publication_date | 2024-08-25 |
| publication_year | 2024 |
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