Inulin Supplementation Modulates the Hepatic Transcriptome, Metabolome, and Ferritin Content in Ovariectomized Rats Article Swipe
Xiaorui Zhao
,
Weiwei He
,
Louise Margrethe Arildsen Jakobsen
,
Line Fisker Zachariassen
,
Axel Kornerup Hansen
,
Martin Krøyer Rasmussen
,
Hanne Christine Bertram
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/mnfr.202300372
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/mnfr.202300372
Scope Liver is an important metabolic organ regulating whole‐body homeostasis. This study aims to investigate how prebiotic‐induced changes in the metabolic activity of the gut microbiome (GM) and dietary calcium depletion modulates the hepatic metabolome and transcriptome. Methods and results The serum metabolome, liver metabolome, and transcriptome are determined on samples from ovariectomized (OVX) rats fed a control diet (Control, n = 7), a control diet supplemented with 5% w/w inulin (Inulin, n = 7), or a calcium‐deficient diet (CaDef, n = 7). Inulin fortification is associated with higher serum concentrations of acetate, 3‐hydroxybutyrate, and reduced concentration of dimethyl sulfone, revealing that changes in the metabolic activity of the GM are reflected in circulating metabolites. Metabolomics also reveal that the inulin‐fortified diet results in lower concentrations of hepatic glutamate, serine, and hypoxanthine while transcriptomics reveal accompanying effects on the hepatic expression of ferric iron binding‐related genes. Inulin fortification also induces effects on the hepatic expression of genes involved in olfactory transduction, suggesting that prebiotics regulate liver function through yet unidentified mechanisms involving olfactory receptors. Conclusion Inulin ingestion impacts hepatic gene expression and is associated with an upregulation of ferritin synthesis‐related genes and liver ferritin content.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/mnfr.202300372
- OA Status
- hybrid
- Cited By
- 3
- References
- 61
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W4387728941Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/mnfr.202300372Digital Object Identifier
- Title
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Inulin Supplementation Modulates the Hepatic Transcriptome, Metabolome, and Ferritin Content in Ovariectomized RatsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-10-17Full publication date if available
- Authors
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Xiaorui Zhao, Weiwei He, Louise Margrethe Arildsen Jakobsen, Line Fisker Zachariassen, Axel Kornerup Hansen, Martin Krøyer Rasmussen, Hanne Christine BertramList of authors in order
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https://doi.org/10.1002/mnfr.202300372Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1002/mnfr.202300372Direct OA link when available
- Concepts
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Metabolome, Transcriptome, Ovariectomized rat, Ferritin, Inulin, Metabolomics, Endocrinology, Internal medicine, Chemistry, Biochemistry, Biology, Medicine, Gene expression, Chromatography, Gene, EstrogenTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2025: 1, 2024: 2Per-year citation counts (last 5 years)
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61Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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