Inverse relationship between Fusobacterium nucleatum amount and tumor CD274 (PD‐L1 ) expression in colorectal carcinoma
Article Swipe
Tomotaka Ugai
,
Takashi Shimizu
,
Hidetaka Kawamura
,
Satoko Ugai
,
Yasutoshi Takashima
,
Genki Usui
,
Juha P. Väyrynen
,
Kazuo Okadome
,
Koichiro Haruki
,
Naohiko Akimoto
,
Yohei Masugi
,
Annacarolina da Silva
,
Kosuke Mima
,
Xuehong Zhang
,
Andrew T. Chan
,
Molin Wang
,
Wendy S. Garrett
,
Gordon J. Freeman
,
Jeffrey A. Meyerhardt
,
Jonathan A. Nowak
,
Mingyang Song
,
Marios Giannakis
,
Shuji Ogino
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/cti2.1453
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/cti2.1453
Objectives The CD274 (programmed cell death 1 ligand 1, PD‐L1)/PDCD1 (programmed cell death 1, PD‐1) immune checkpoint axis is known to regulate the antitumor immune response. Evidence also supports an immunosuppressive effect of Fusobacterium nucleatum . We hypothesised that tumor CD274 overexpression might be inversely associated with abundance of F. nucleatum in colorectal carcinoma. Methods We assessed tumor CD274 expression by immunohistochemistry and F. nucleatum DNA within tumor tissue by quantitative PCR in 812 cases among 4465 incident rectal and colon cancer cases that had occurred in two prospective cohort studies. Multivariable logistic regression analyses with inverse probability weighting were used to adjust for selection bias because of tissue data availability and potential confounders including microsatellite instability status, CpG island methylator phenotype, LINE‐1 methylation level and KRAS , BRAF and PIK3CA mutations. Results Fusobacterium nucleatum DNA was detected in tumor tissue in 109 (13%) cases. Tumor CD274 expression level was inversely associated with the amount of F. nucleatum in colorectal cancer tissue ( P = 0.0077). For one category‐unit increase in three ordinal F. nucleatum categories (negative vs. low vs. high), multivariable‐adjusted odds ratios (with 95% confidence interval) of the low, intermediate and high CD274 categories (vs. negative) were 0.78 (0.41–1.51), 0.64 (0.32–1.28) and 0.50 (0.25–0.99), respectively ( P trend = 0.032). Conclusions Tumor CD274 expression level was inversely associated with the amount of F. nucleatum in colorectal cancer tissue, suggesting that different immunosuppressive mechanisms (i.e. PDCD1 immune checkpoint activation and tumor F. nucleatum enrichment) tend to be used by different tumor subgroups.
Related Topics
Concepts
Fusobacterium nucleatum
Colorectal cancer
Microsatellite instability
Cancer research
Immune checkpoint
Tissue microarray
KRAS
Medicine
Cancer
Biology
Oncology
Immunology
Internal medicine
Immunotherapy
Genetics
Gene
Allele
Periodontitis
Microsatellite
Porphyromonas gingivalis
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/cti2.1453
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cti2.1453
- OA Status
- gold
- Cited By
- 8
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4385500231
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4385500231Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/cti2.1453Digital Object Identifier
- Title
-
Inverse relationship between Fusobacterium nucleatum amount and tumor
CD274 (PD‐L1 ) expression in colorectal carcinomaWork title - Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-01Full publication date if available
- Authors
-
Tomotaka Ugai, Takashi Shimizu, Hidetaka Kawamura, Satoko Ugai, Yasutoshi Takashima, Genki Usui, Juha P. Väyrynen, Kazuo Okadome, Koichiro Haruki, Naohiko Akimoto, Yohei Masugi, Annacarolina da Silva, Kosuke Mima, Xuehong Zhang, Andrew T. Chan, Molin Wang, Wendy S. Garrett, Gordon J. Freeman, Jeffrey A. Meyerhardt, Jonathan A. Nowak, Mingyang Song, Marios Giannakis, Shuji OginoList of authors in order
- Landing page
-
https://doi.org/10.1002/cti2.1453Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cti2.1453Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cti2.1453Direct OA link when available
- Concepts
-
Fusobacterium nucleatum, Colorectal cancer, Microsatellite instability, Cancer research, Immune checkpoint, Tissue microarray, KRAS, Medicine, Cancer, Biology, Oncology, Immunology, Internal medicine, Immunotherapy, Genetics, Gene, Allele, Periodontitis, Microsatellite, Porphyromonas gingivalisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
54Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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