Investigating the association between the tissue expression of miRNA‐101, JAK2/STAT3 with TNF‐α, IL‐6, IL‐1β, and IL‐10 cytokines in the ulcerative colitis patients Article Swipe
Qazaleh Voshagh
,
Amir Anoshiravani
,
Amin Karimpour
,
Golnaz Goodarzi
,
Sadra Samavarchi Tehrani
,
Ozra Tabatabaei‐Malazy
,
Ghodratollah Panahi
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/iid3.1224
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/iid3.1224
Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease caused by numerous factors, such as immune system dysfunction and genetic factors. MicroRNAs (miRNAs) play a crucial role in UC pathogenesis, particularly via the JAK‐STAT pathway. Our aim was to investigate the association between miRNA‐101 and JAK2‐STAT3 signaling pathway with inflammatory cytokines in UC patients. Methods We enrolled 35 UC patients and 35 healthy individuals as the control group, referred to Shariati Hospital, Tehran, Iran. Patients were diagnosed based on clinical, laboratory, histological, and colonoscopy criteria. RNA and protein extracted from tissue samples. Real‐time PCR was used to assess the expression levels of miRNA‐101, interleukin (IL)‐1β, IL‐6, tumor necrosis factor (TNF)‐α, and IL‐10 genes, while western blot was employed to measure levels of P‐STAT3, total STAT3, and JAK2 proteins. Results Expression of pro‐inflammatory cytokines TNF‐α, IL‐1β, and IL‐6 significantly increased, while the expression of IL‐10 significantly decreased in the case group versus controls. Additionally, miRNA‐101 expression was significantly higher in UC patients. A significant correlation between miRNA‐101 and IL‐6 expression was observed, indicating their relationship and possible impact on cell signaling pathways, JAK2‐STAT3. No significant changes were observed in phosphorylated and total STAT3 and JAK2 protein expression. Conclusion This study provides evidence of increased miRNA‐101 expression in UC tissue, suggesting a potential correlation between miRNA‐101 and IL‐6 expression and their involvement in the JAK2‐STAT3 pathway. The study confirms alterations in UC patients' pro‐inflammatory cytokines and anti‐inflammatory IL‐10. However, further investigations are needed to understand the exact role of miRNA‐101 in UC pathogenesis fully.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/iid3.1224
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iid3.1224
- OA Status
- gold
- Cited By
- 13
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393086149
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4393086149Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/iid3.1224Digital Object Identifier
- Title
-
Investigating the association between the tissue expression of miRNA‐101, JAK2/STAT3 with TNF‐α, IL‐6, IL‐1β, and IL‐10 cytokines in the ulcerative colitis patientsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-01Full publication date if available
- Authors
-
Qazaleh Voshagh, Amir Anoshiravani, Amin Karimpour, Golnaz Goodarzi, Sadra Samavarchi Tehrani, Ozra Tabatabaei‐Malazy, Ghodratollah PanahiList of authors in order
- Landing page
-
https://doi.org/10.1002/iid3.1224Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iid3.1224Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iid3.1224Direct OA link when available
- Concepts
-
microRNA, Ulcerative colitis, Tumor necrosis factor alpha, STAT3, Medicine, Pathogenesis, Proinflammatory cytokine, Interleukin, Inflammatory bowel disease, Western blot, Immunology, Inflammation, Cancer research, Signal transduction, Cytokine, Biology, Internal medicine, Disease, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
13Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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42Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.control | 68 |
| abstract_inverted_index.crucial | 27 |
| abstract_inverted_index.disease | 10 |
| abstract_inverted_index.further | 239 |
| abstract_inverted_index.genetic | 21 |
| abstract_inverted_index.healthy | 64 |
| abstract_inverted_index.measure | 121 |
| abstract_inverted_index.pathway | 49 |
| abstract_inverted_index.protein | 89, 196 |
| abstract_inverted_index.tissue, | 209 |
| abstract_inverted_index.western | 116 |
| abstract_inverted_index.(miRNAs) | 24 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.However, | 238 |
| abstract_inverted_index.IL‐10. | 237 |
| abstract_inverted_index.Patients | 76 |
| abstract_inverted_index.Shariati | 72 |
| abstract_inverted_index.confirms | 228 |
| abstract_inverted_index.employed | 119 |
| abstract_inverted_index.enrolled | 58 |
| abstract_inverted_index.evidence | 202 |
| abstract_inverted_index.factors, | 14 |
| abstract_inverted_index.factors. | 22 |
| abstract_inverted_index.necrosis | 109 |
| abstract_inverted_index.numerous | 13 |
| abstract_inverted_index.observed | 188 |
| abstract_inverted_index.pathway. | 36, 225 |
| abstract_inverted_index.patients | 61 |
| abstract_inverted_index.possible | 177 |
| abstract_inverted_index.provides | 201 |
| abstract_inverted_index.referred | 70 |
| abstract_inverted_index.samples. | 93 |
| abstract_inverted_index.Hospital, | 73 |
| abstract_inverted_index.IL‐1β, | 136 |
| abstract_inverted_index.MicroRNAs | 23 |
| abstract_inverted_index.TNF‐α, | 135 |
| abstract_inverted_index.clinical, | 81 |
| abstract_inverted_index.controls. | 153 |
| abstract_inverted_index.criteria. | 86 |
| abstract_inverted_index.cytokines | 52, 134, 234 |
| abstract_inverted_index.decreased | 147 |
| abstract_inverted_index.diagnosed | 78 |
| abstract_inverted_index.extracted | 90 |
| abstract_inverted_index.increased | 204 |
| abstract_inverted_index.observed, | 172 |
| abstract_inverted_index.pathways, | 182 |
| abstract_inverted_index.patients' | 232 |
| abstract_inverted_index.patients. | 55, 162 |
| abstract_inverted_index.potential | 212 |
| abstract_inverted_index.proteins. | 129 |
| abstract_inverted_index.signaling | 48, 181 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Conclusion | 198 |
| abstract_inverted_index.Expression | 131 |
| abstract_inverted_index.JAK‐STAT | 35 |
| abstract_inverted_index.P‐STAT3, | 124 |
| abstract_inverted_index.Ulcerative | 2 |
| abstract_inverted_index.expression | 101, 143, 156, 170, 206, 218 |
| abstract_inverted_index.increased, | 140 |
| abstract_inverted_index.indicating | 173 |
| abstract_inverted_index.suggesting | 210 |
| abstract_inverted_index.understand | 244 |
| abstract_inverted_index.(IL)‐1β, | 106 |
| abstract_inverted_index.(TNF)‐α, | 111 |
| abstract_inverted_index.Real‐time | 94 |
| abstract_inverted_index.alterations | 229 |
| abstract_inverted_index.association | 43 |
| abstract_inverted_index.colonoscopy | 85 |
| abstract_inverted_index.correlation | 165, 213 |
| abstract_inverted_index.dysfunction | 19 |
| abstract_inverted_index.expression. | 197 |
| abstract_inverted_index.individuals | 65 |
| abstract_inverted_index.interleukin | 105 |
| abstract_inverted_index.investigate | 41 |
| abstract_inverted_index.involvement | 221 |
| abstract_inverted_index.laboratory, | 82 |
| abstract_inverted_index.miRNA‐101 | 45, 155, 167, 205, 215, 249 |
| abstract_inverted_index.significant | 164, 185 |
| abstract_inverted_index.JAK2‐STAT3 | 47, 224 |
| abstract_inverted_index.inflammatory | 8, 51 |
| abstract_inverted_index.miRNA‐101, | 104 |
| abstract_inverted_index.particularly | 32 |
| abstract_inverted_index.pathogenesis | 252 |
| abstract_inverted_index.relationship | 175 |
| abstract_inverted_index.Additionally, | 154 |
| abstract_inverted_index.JAK2‐STAT3. | 183 |
| abstract_inverted_index.histological, | 83 |
| abstract_inverted_index.pathogenesis, | 31 |
| abstract_inverted_index.significantly | 139, 146, 158 |
| abstract_inverted_index.investigations | 240 |
| abstract_inverted_index.phosphorylated | 190 |
| abstract_inverted_index.pro‐inflammatory | 133, 233 |
| abstract_inverted_index.anti‐inflammatory | 236 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5048633577, https://openalex.org/A5014161154 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I70640408 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7900000214576721 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.9612697 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |