Investigating the in vitro photothermal effect of green synthesized apigenin‐coated gold nanoparticle on colorectal carcinoma Article Swipe
Seyed Mohammad Amini
,
Elham Mohammadi
,
Shaghayegh Askarian‐Amiri
,
Yaser Azizi
,
Ali Shakeri‐Zadeh
,
Ali Neshasteh‐Riz
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1049/nbt2.12016
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1049/nbt2.12016
Applying toxic chemical to the synthesis of stable gold nanoparticles is one of the limitations of gold nanoparticles for therapeutic applications such as photothermal therapy. Plant compounds such as apigenin (API) with therapeutic potential can be applied in the synthesis of gold nanoparticles. API‐coated gold nanoparticles (Api@AuNPs) with an average size of 19.1 nm and a surface charge of −4.3 mV have been synthesized by a simple and efficient technique. The stability of Api@AuNPs in the biological environment was verified through UV‐Vis spectroscopy. Based on Raman and FTIR spectroscopy analysis, chemical binding of API on the surface of Api@AuNPs through hydroxyl and carbonyl functional groups was found to be the main reason for the stability of the Api@AuNPs in comparison with citrate‐coated gold nanoparticles (Cit@AuNPs). The synthesized Api@AuNPs do not cause major toxic effects up to 128 ppm. Api@AuNP‐mediated photothermal therapy leads to the indiscriminate eradication of almost half of both mouse fibroblastic (L929) and colorectal cancer (CT26) cells. Flow‐cytometry analysis revealed that the cell death mechanism is mainly apoptosis. In the apoptosis triggered cell death in photothermal treatment, Api@AuNPs are preferred over commonly used gold nanoparticles in photothermal treatments which mostly trigger the necrosis cell death pathway.
Related Topics
Concepts
Photothermal therapy
Colloidal gold
Nanoparticle
Nanotechnology
Surface-enhanced Raman spectroscopy
Surface modification
Chemistry
Materials science
Apigenin
Raman spectroscopy
Organic chemistry
Antioxidant
Raman scattering
Optics
Flavonoid
Physics
Physical chemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1049/nbt2.12016
- OA Status
- gold
- Cited By
- 43
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3131615262
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3131615262Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1049/nbt2.12016Digital Object Identifier
- Title
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Investigating the in vitro photothermal effect of green synthesized apigenin‐coated gold nanoparticle on colorectal carcinomaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-02-22Full publication date if available
- Authors
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Seyed Mohammad Amini, Elham Mohammadi, Shaghayegh Askarian‐Amiri, Yaser Azizi, Ali Shakeri‐Zadeh, Ali Neshasteh‐RizList of authors in order
- Landing page
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https://doi.org/10.1049/nbt2.12016Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.1049/nbt2.12016Direct OA link when available
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Photothermal therapy, Colloidal gold, Nanoparticle, Nanotechnology, Surface-enhanced Raman spectroscopy, Surface modification, Chemistry, Materials science, Apigenin, Raman spectroscopy, Organic chemistry, Antioxidant, Raman scattering, Optics, Flavonoid, Physics, Physical chemistryTop concepts (fields/topics) attached by OpenAlex
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43Total citation count in OpenAlex
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2025: 9, 2024: 18, 2023: 8, 2022: 6, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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32Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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