Investigating the pathophysiology and evolution of internal carotid dissection: a fluid–structure interaction simulation study Article Swipe
Adriano Bonura
,
Giulio Musotto
,
Gianmarco Iaccarino
,
Sergio Rossi
,
Rosalinda Calandrelli
,
Fioravante Capone
,
Vincenzo Di Lazzaro
,
Fabio Pilato
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2024.1455989
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2024.1455989
Background Arterial dissection, a condition marked by the tearing of the carotid artery’s inner layers, can result in varied clinical outcomes, including progression, stability, or spontaneous regression. Understanding these outcomes’ underlying mechanisms is crucial for enhancing patient care, particularly with the increasing use of computer simulations in medical diagnostics and treatment planning. The aim of this study is to utilize computational analysis of blood flow and vascular wall to: (1) understand the pathophysiology of stroke-like episodes in patients with carotid artery dissection; and (2) assess the effectiveness of this method in predicting the evolution of carotid dissection. Methods Utilizing contrast-enhanced magnetic resonance angiography (MRA), we segmented images of the patient’s right internal carotid artery. These images were transformed into 3D solids for simulation in Ansys multifisic software, employing a two-way fluid structure interaction (FSI) analysis. Simulations were conducted across two wall conditions (atherosclerotic and normal) and three pressure states (hypotension, normotension, hypertension). Results The simulations indicated a significant pressure discrepancy between the true and false lumens of the artery. This suggests that flap motion and functional occlusion under hypertensive conditions could be the cause of the clinical episodes. Thrombotic risk and potential for dissection extension were not found to be critical concerns. However, a non-negligible risk of vessel dilation was assessed, aligning with the patient’s clinical follow-up data. Conclusion This study highlights specific hemodynamic parameters that could elucidate carotid artery dissection’s mechanisms, offering a potential predictive tool for assessing dissection progression and informing personalized patient care strategies.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fneur.2024.1455989
- OA Status
- gold
- Cited By
- 4
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403003638
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4403003638Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fneur.2024.1455989Digital Object Identifier
- Title
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Investigating the pathophysiology and evolution of internal carotid dissection: a fluid–structure interaction simulation studyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-09-30Full publication date if available
- Authors
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Adriano Bonura, Giulio Musotto, Gianmarco Iaccarino, Sergio Rossi, Rosalinda Calandrelli, Fioravante Capone, Vincenzo Di Lazzaro, Fabio PilatoList of authors in order
- Landing page
-
https://doi.org/10.3389/fneur.2024.1455989Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3389/fneur.2024.1455989Direct OA link when available
- Concepts
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Medicine, Carotid artery dissection, Dissection (medical), Stroke (engine), Radiology, Magnetic resonance angiography, Cardiology, Arterial dissection, Magnetic resonance imaging, Hemodynamics, Internal carotid artery, Internal medicine, Surgery, Mechanical engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4Per-year citation counts (last 5 years)
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58Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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