Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects Article Swipe
Yu Han
,
Wanlu Liu
,
Kexin Li
,
M. Zhang
,
Xinqi Liu
,
Lu Li
,
Zhao Guo
,
He Li
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/foods14010058
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/foods14010058
Hyperuricemia, a disorder of purine metabolism associated with cardiovascular disease, gout, and kidney disease, can be alleviated by food-derived peptides. However, the precise mechanisms remain unclear, hindering their development. This study reviews uric acid-lowering peptides from various sources, focusing on two pathways: inhibiting uric acid production and promoting excretion. Low-molecular-weight peptides (<1000 Da) exhibited superior uric acid-lowering effects. We further explored the relationships between amino acid composition and their target interactions. Peptides rich in cyclic amino acids (tryptophan, phenylalanine, and histidine) and containing small amounts of linear amino acids (leucine, cysteine, and glycine) demonstrated significant potential for lowering uric acid. These findings provide theoretical support for developing novel functional foods for the management of hyperuricemia.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/foods14010058
- https://www.mdpi.com/2304-8158/14/1/58/pdf?version=1735540147
- OA Status
- gold
- Cited By
- 2
- References
- 89
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405928246
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405928246Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/foods14010058Digital Object Identifier
- Title
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Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural EffectsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-12-28Full publication date if available
- Authors
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Yu Han, Wanlu Liu, Kexin Li, M. Zhang, Xinqi Liu, Lu Li, Zhao Guo, He LiList of authors in order
- Landing page
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https://doi.org/10.3390/foods14010058Publisher landing page
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https://www.mdpi.com/2304-8158/14/1/58/pdf?version=1735540147Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2304-8158/14/1/58/pdf?version=1735540147Direct OA link when available
- Concepts
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Hyperuricemia, Uric acid, Gout, Amino acid, Chemistry, Biochemistry, Purine, Glycine, Pharmacology, Medicine, EnzymeTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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