Investigation of anti-Alzheimer’s activity of aqueous extract of areca nuts (Areca catechu L.): In vitro and in vivo studies Article Swipe
Mahboubeh Bozorgi
,
Zahra Najafi
,
Sahar Omidpanah
,
Arash Sadri
,
Zahra Narimani
,
Farshad Homayouni Moghadam
,
Najmeh Edraki
,
Tahmineh Akbarzadeh
,
Mina Saeedi
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.37360/blacpma.21.20.4.30
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.37360/blacpma.21.20.4.30
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder. Sever cognitive and memory impairments, huge increase in the prevalence of the disease, and lacking definite cure have absorbed worldwide efforts to develop therapeutic approaches. Since many drugs have failed in the clinical trials due to multifactorial nature of AD, symptomatic treatments are still in the center attention and now, nootropic medicinal plants have been found as versatile ameliorators to reverse memory disorders. In this work, anti-Alzheimer’s activity of aqueous extract of areca nuts (Areca catechu L.) was investigated via in vitro and in vivo studies. It depicted good amyloid β (Aβ) aggregation inhibitory activity, 82% at 100 µg/mL. In addition, it inhibited beta-secretase 1 (BACE1) with IC50 value of 19.03 µg/mL. Evaluation of neuroprotectivity of the aqueous extract of the plant against H2O2-induced cell death in PC12 neurons revealed 84.5% protection at 1 µg/mL. It should be noted that according to our results obtained from Morris Water Maze (MWM) test, the extract reversed scopolamine-induced memory deficit in rats at concentrations of 1.5 and 3 mg/kg.
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Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.37360/blacpma.21.20.4.30
- OA Status
- diamond
- Cited By
- 7
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3136365892
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3136365892Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.37360/blacpma.21.20.4.30Digital Object Identifier
- Title
-
Investigation of anti-Alzheimer’s activity of aqueous extract of areca nuts (Areca catechu L.): In vitro and in vivo studiesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-03-23Full publication date if available
- Authors
-
Mahboubeh Bozorgi, Zahra Najafi, Sahar Omidpanah, Arash Sadri, Zahra Narimani, Farshad Homayouni Moghadam, Najmeh Edraki, Tahmineh Akbarzadeh, Mina SaeediList of authors in order
- Landing page
-
https://doi.org/10.37360/blacpma.21.20.4.30Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.37360/blacpma.21.20.4.30Direct OA link when available
- Concepts
-
Areca, Catechu, In vivo, Morris water navigation task, Pharmacology, Traditional medicine, Amyloid beta, In vitro, IC50, Medicine, Nootropic, Alzheimer's disease, Chemistry, Disease, Biology, Hippocampus, Biochemistry, Biotechnology, Internal medicine, Nut, Structural engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 3, 2023: 2, 2021: 2Per-year citation counts (last 5 years)
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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