Investigation of bioactive constituents and evaluation of different in vitro antimicrobial, antioxidant, and cytotoxicity potentials of different Portulacaria afra extracts Article Swipe
Shumaila Ijaz
,
Javed Iqbal
,
Banzeer Ahsan Abbasi
,
Sobia Kanwal
,
Maryam Tavafoghi
,
Mohammad Z. Ahmed
,
Tariq Mahmood
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.jksus.2023.103033
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.jksus.2023.103033
The use of medicinal plants exists before the existence of humans. Healing with herbal treatments is of utmost significance because medicinal plants contain bioactive compounds. The objective of the current investigation was to evaluate the biological potential of methanolic (PAM) and chloroform (PAC) extracts of Portulacaria afra root, leaf, seed and flower. FT-IR (Fourier Transform Infrared Spectroscopy) spectroscopy was completed to detect the different functional groups. Total antioxidant capacity (TAC), total reducing power (TRP) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assays, were done for the determination of antioxidant potential of medicinal plant P. afra. Five different bacterial strains were used to evaluate the antibacterial potential using disc diffusion method. Cytotoxicity assay was used to test the cytotoxic potential against brine shrimps and shown the maximum cytotoxic potential with lowest IC50 value (41.41 ± 0.80 µg/mL) in PAM. Radish seed germination phytotoxicity assay was performed and revealed the highest phytotoxic potential in PAM extract. ANOVA was applied via statistics version-8.1, and experimentations were done in triplicates. Maximum DPPH scavenging potential was observed in methanol extract of P. afra (PAM). The PAM extract has the highest flavonoid concentration (30.70 mg/g). PAM demonstrated maximum total reducing power (73.46 gallic acid equivalents per gram (GAE/g). Antibacterial activity was performed against different bacterial strains and PAM shown the best antibacterial activity with largest zone of inhibition (17 mm) contrary to Pseudomonas aeruginosa. The bioactive compounds found in P. afra extracts have antibacterial, antioxidant, and cytotoxic properties, revealing their ability to induce cell death in cancerous cell lines, indicating potential anticancer agents and making them intriguing candidates for future research and the possible creation of new therapeutics. we advise the use of these extracts against biofilms as these extracts have shown significant antibacterial activity against gram negative bacteria“.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jksus.2023.103033
- OA Status
- gold
- Cited By
- 15
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389060295
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4389060295Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.jksus.2023.103033Digital Object Identifier
- Title
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Investigation of bioactive constituents and evaluation of different in vitro antimicrobial, antioxidant, and cytotoxicity potentials of different Portulacaria afra extractsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-11-27Full publication date if available
- Authors
-
Shumaila Ijaz, Javed Iqbal, Banzeer Ahsan Abbasi, Sobia Kanwal, Maryam Tavafoghi, Mohammad Z. Ahmed, Tariq MahmoodList of authors in order
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https://doi.org/10.1016/j.jksus.2023.103033Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.jksus.2023.103033Direct OA link when available
- Concepts
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DPPH, Antimicrobial, Gallic acid, Antibacterial activity, Traditional medicine, Antioxidant, Chemistry, Flavonoid, Cytotoxicity, Agar diffusion test, Food science, Biology, Biochemistry, In vitro, Bacteria, Organic chemistry, Medicine, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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15Total citation count in OpenAlex
- Citations by year (recent)
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2025: 9, 2024: 6Per-year citation counts (last 5 years)
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47Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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