Investigation of Different Molecular Weight Fucoidan Fractions Derived from New Zealand Undaria pinnatifida in Combination with GroA Therapy in Prostate Cancer Cell Lines Article Swipe
Xu Yang
,
Sheng Wang
,
Sari Schokoroy Trangle
,
Yan Li
,
William Lindsey White
,
Jinyao Li
,
Tianlei Ying
,
Qingjun Kong
,
Yu Zhao
,
Jun Lu
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3390/md16110454
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3390/md16110454
Fucoidan, a sulfated polysaccharide extracted from brown seaweeds, has been shown to possess various antioxidant, anticoagulant, antiviral, and anticancer functions. In this study, we focused on low molecular weight fucoidan (LMWF) which was extracted from New Zealand Undaria pinnatifida, and investigated its anti-proliferative effects, combined with a quadruplex-forming oligonucleotide aptamer (GroA, AS1411), a powerful cell surface Nucleolin inhibitor, in prostate cancer cells. We examined LMWF (<10 kDa) and compared it with laboratory grade Fucoidan purchased from Sigma (FS), all extracted from the same seaweed species U. pinnatifida. We found that LMWF significantly improved the anti-proliferative effect of GroA, as it decreased cancer cell growth and viability and increased cell death. This research may provide the foundation for LMWF to be used against prostate cancers as a supplement therapy in combination with other therapeutic agents.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/md16110454
- https://www.mdpi.com/1660-3397/16/11/454/pdf?version=1542531643
- OA Status
- gold
- Cited By
- 21
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2900747943
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Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2900747943Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/md16110454Digital Object Identifier
- Title
-
Investigation of Different Molecular Weight Fucoidan Fractions Derived from New Zealand Undaria pinnatifida in Combination with GroA Therapy in Prostate Cancer Cell LinesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-11-18Full publication date if available
- Authors
-
Xu Yang, Sheng Wang, Sari Schokoroy Trangle, Yan Li, William Lindsey White, Jinyao Li, Tianlei Ying, Qingjun Kong, Yu Zhao, Jun LuList of authors in order
- Landing page
-
https://doi.org/10.3390/md16110454Publisher landing page
- PDF URL
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https://www.mdpi.com/1660-3397/16/11/454/pdf?version=1542531643Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1660-3397/16/11/454/pdf?version=1542531643Direct OA link when available
- Concepts
-
Fucoidan, Prostate cancer, Cell growth, Antioxidant, Polysaccharide, Cancer research, Viability assay, Biology, Pharmacology, Apoptosis, Cancer, Traditional medicine, Biochemistry, Medicine, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
21Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 1, 2023: 3, 2022: 4, 2021: 4Per-year citation counts (last 5 years)
- References (count)
-
51Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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