Investigation of PANoptosis pathway in age-related macular degeneration triggered by Aβ1-40 Article Swipe
Yuxia He
,
Jing Lu
,
Yong Du
,
Long Zhao
,
Lili Gong
,
Ping Wu
,
Qinxin Shu
,
Hui Peng
,
Xing Wang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-025-98174-x
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-025-98174-x
Our study aimed to identify PANoptosis in Aβ1-40-induced AMD, both in vivo and in vitro, and to determine if AIM2-PANoptosome mediates this process. We used transcriptomics to explore the signaling pathways and target genes linked to PANoptosis within a mouse model of AMD triggered by Aβ1-40. Optical coherence tomography (OCT), hematoxylin and eosin (H&E) staining, and electroretinography (ERG) were employed to assess retinal damage in terms of morphology and function. Morphological changes in ARPE-19 cells were observed using optical microscopy and scanning electron microscopy. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of cytokines in cell supernatants, mouse orbital serum, and human plasma to evaluate the severity of inflammation. CO-immunoprecipitation(CoIP) and molecular docking were performed to assess the impact and expression of proteins associated with the AIM2-PANoptosome. Quantitative polymerase chain reaction (qPCR), Western blot (WB), immunofluorescence, and apoptosis detection kits were used to evaluate the expression levels of genes and proteins related to PANoptosis-like cell death. Our results showed that the Aβ1-40-induced AMD model had increased expression of apoptosis, necroptosis, and pyroptosis pathways, and AIM2-PANoptosome components. CoIP and docking confirmed increased AIM2, ZBP1, and PYRIN levels under Aβ1-40 treatment. WB and immunofluorescence showed upregulation of PANoptosis-related proteins. Inhibitors reduced Aβ-induced protein expression. ELISA showed increased inflammatory cytokines. Apoptosis assays and microscopy revealed Aβ1-40-induced ARPE-19 cell loss and morphological changes. In conclusion, the Aβ1-40-induced AMD model displayed PANoptosis-like cell death, offering insights into disease pathogenesis.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-025-98174-x
- https://www.nature.com/articles/s41598-025-98174-x.pdf
- OA Status
- gold
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409578456
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409578456Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41598-025-98174-xDigital Object Identifier
- Title
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Investigation of PANoptosis pathway in age-related macular degeneration triggered by Aβ1-40Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-19Full publication date if available
- Authors
-
Yuxia He, Jing Lu, Yong Du, Long Zhao, Lili Gong, Ping Wu, Qinxin Shu, Hui Peng, Xing WangList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-025-98174-xPublisher landing page
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https://www.nature.com/articles/s41598-025-98174-x.pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41598-025-98174-x.pdfDirect OA link when available
- Concepts
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Macular degeneration, Degeneration (medical), Retinal degeneration, Medicine, Biology, Ophthalmology, Computer science, RetinalTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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| publication_date | 2025-04-19 |
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| referenced_works | https://openalex.org/W4211199473, https://openalex.org/W2969630964, https://openalex.org/W2160226180, https://openalex.org/W3181865734, https://openalex.org/W2115483148, https://openalex.org/W2033662964, https://openalex.org/W2122106651, https://openalex.org/W2007014682, https://openalex.org/W2111274886, https://openalex.org/W3096272935, https://openalex.org/W2507605260, https://openalex.org/W3015080429, https://openalex.org/W3125007765, https://openalex.org/W2610420640, https://openalex.org/W2991204446, https://openalex.org/W3031478418, https://openalex.org/W4394980168, https://openalex.org/W4407719651, https://openalex.org/W1615358991, https://openalex.org/W2111586778, https://openalex.org/W2085350682, https://openalex.org/W3138285868, https://openalex.org/W4403587119, https://openalex.org/W4380681058, https://openalex.org/W4294216483, https://openalex.org/W3197986920, https://openalex.org/W1982531297, https://openalex.org/W2161818169, https://openalex.org/W2264982258, https://openalex.org/W1606082686, https://openalex.org/W2981698255, https://openalex.org/W1990624781, https://openalex.org/W2462773201, https://openalex.org/W3038727844, https://openalex.org/W2903400692, https://openalex.org/W3034103545, https://openalex.org/W3193190854, https://openalex.org/W3138429921, https://openalex.org/W4402630518, https://openalex.org/W3022981886, https://openalex.org/W2121075882, https://openalex.org/W3103916466, https://openalex.org/W3114255466, https://openalex.org/W2977759024, https://openalex.org/W2559175446, https://openalex.org/W4387836855, https://openalex.org/W2937660509, https://openalex.org/W1991743283, https://openalex.org/W2033968700, https://openalex.org/W1966977448, https://openalex.org/W3105908160, https://openalex.org/W2159482845, https://openalex.org/W4399731408, https://openalex.org/W4205783163, https://openalex.org/W4406537045, https://openalex.org/W4405810230 |
| referenced_works_count | 56 |
| abstract_inverted_index.a | 38 |
| abstract_inverted_index.In | 221 |
| abstract_inverted_index.WB | 191 |
| abstract_inverted_index.We | 23 |
| abstract_inverted_index.by | 44 |
| abstract_inverted_index.if | 18 |
| abstract_inverted_index.in | 6, 10, 13, 64, 72, 96 |
| abstract_inverted_index.of | 41, 66, 94, 109, 123, 149, 169, 196 |
| abstract_inverted_index.to | 3, 16, 26, 35, 60, 90, 105, 117, 144, 154 |
| abstract_inverted_index.AMD | 42, 164, 225 |
| abstract_inverted_index.Our | 0, 158 |
| abstract_inverted_index.and | 12, 15, 31, 51, 55, 68, 80, 102, 112, 121, 138, 151, 172, 175, 179, 185, 192, 211, 218 |
| abstract_inverted_index.had | 166 |
| abstract_inverted_index.the | 28, 92, 107, 119, 127, 146, 162, 223 |
| abstract_inverted_index.was | 88 |
| abstract_inverted_index.AMD, | 8 |
| abstract_inverted_index.CoIP | 178 |
| abstract_inverted_index.blot | 135 |
| abstract_inverted_index.both | 9 |
| abstract_inverted_index.cell | 97, 156, 216, 229 |
| abstract_inverted_index.into | 233 |
| abstract_inverted_index.kits | 141 |
| abstract_inverted_index.loss | 217 |
| abstract_inverted_index.that | 161 |
| abstract_inverted_index.this | 21 |
| abstract_inverted_index.used | 24, 89, 143 |
| abstract_inverted_index.vivo | 11 |
| abstract_inverted_index.were | 58, 75, 115, 142 |
| abstract_inverted_index.with | 126 |
| abstract_inverted_index.(ERG) | 57 |
| abstract_inverted_index.(H&E) | 53 |
| abstract_inverted_index.(WB), | 136 |
| abstract_inverted_index.AIM2, | 183 |
| abstract_inverted_index.ELISA | 204 |
| abstract_inverted_index.PYRIN | 186 |
| abstract_inverted_index.ZBP1, | 184 |
| abstract_inverted_index.aimed | 2 |
| abstract_inverted_index.assay | 86 |
| abstract_inverted_index.cells | 74 |
| abstract_inverted_index.chain | 131 |
| abstract_inverted_index.eosin | 52 |
| abstract_inverted_index.genes | 33, 150 |
| abstract_inverted_index.human | 103 |
| abstract_inverted_index.model | 40, 165, 226 |
| abstract_inverted_index.mouse | 39, 99 |
| abstract_inverted_index.study | 1 |
| abstract_inverted_index.terms | 65 |
| abstract_inverted_index.under | 188 |
| abstract_inverted_index.using | 77 |
| abstract_inverted_index.(OCT), | 49 |
| abstract_inverted_index.assays | 210 |
| abstract_inverted_index.assess | 61, 118 |
| abstract_inverted_index.damage | 63 |
| abstract_inverted_index.death, | 230 |
| abstract_inverted_index.death. | 157 |
| abstract_inverted_index.detect | 91 |
| abstract_inverted_index.impact | 120 |
| abstract_inverted_index.levels | 93, 148, 187 |
| abstract_inverted_index.linked | 34 |
| abstract_inverted_index.plasma | 104 |
| abstract_inverted_index.serum, | 101 |
| abstract_inverted_index.showed | 160, 194, 205 |
| abstract_inverted_index.target | 32 |
| abstract_inverted_index.vitro, | 14 |
| abstract_inverted_index.within | 37 |
| abstract_inverted_index.(ELISA) | 87 |
| abstract_inverted_index.(qPCR), | 133 |
| abstract_inverted_index.ARPE-19 | 73, 215 |
| abstract_inverted_index.Aβ1-40 | 189 |
| abstract_inverted_index.Optical | 46 |
| abstract_inverted_index.Western | 134 |
| abstract_inverted_index.changes | 71 |
| abstract_inverted_index.disease | 234 |
| abstract_inverted_index.docking | 114, 180 |
| abstract_inverted_index.explore | 27 |
| abstract_inverted_index.optical | 78 |
| abstract_inverted_index.orbital | 100 |
| abstract_inverted_index.protein | 202 |
| abstract_inverted_index.reduced | 200 |
| abstract_inverted_index.related | 153 |
| abstract_inverted_index.results | 159 |
| abstract_inverted_index.retinal | 62 |
| abstract_inverted_index.Aβ1-40. | 45 |
| abstract_inverted_index.changes. | 220 |
| abstract_inverted_index.electron | 82 |
| abstract_inverted_index.employed | 59 |
| abstract_inverted_index.evaluate | 106, 145 |
| abstract_inverted_index.identify | 4 |
| abstract_inverted_index.insights | 232 |
| abstract_inverted_index.mediates | 20 |
| abstract_inverted_index.observed | 76 |
| abstract_inverted_index.offering | 231 |
| abstract_inverted_index.pathways | 30 |
| abstract_inverted_index.process. | 22 |
| abstract_inverted_index.proteins | 124, 152 |
| abstract_inverted_index.reaction | 132 |
| abstract_inverted_index.revealed | 213 |
| abstract_inverted_index.scanning | 81 |
| abstract_inverted_index.severity | 108 |
| abstract_inverted_index.Apoptosis | 209 |
| abstract_inverted_index.apoptosis | 139 |
| abstract_inverted_index.coherence | 47 |
| abstract_inverted_index.confirmed | 181 |
| abstract_inverted_index.cytokines | 95 |
| abstract_inverted_index.detection | 140 |
| abstract_inverted_index.determine | 17 |
| abstract_inverted_index.displayed | 227 |
| abstract_inverted_index.function. | 69 |
| abstract_inverted_index.increased | 167, 182, 206 |
| abstract_inverted_index.molecular | 113 |
| abstract_inverted_index.pathways, | 174 |
| abstract_inverted_index.performed | 116 |
| abstract_inverted_index.proteins. | 198 |
| abstract_inverted_index.signaling | 29 |
| abstract_inverted_index.staining, | 54 |
| abstract_inverted_index.triggered | 43 |
| abstract_inverted_index.Inhibitors | 199 |
| abstract_inverted_index.PANoptosis | 5, 36 |
| abstract_inverted_index.apoptosis, | 170 |
| abstract_inverted_index.associated | 125 |
| abstract_inverted_index.cytokines. | 208 |
| abstract_inverted_index.expression | 122, 147, 168 |
| abstract_inverted_index.microscopy | 79, 212 |
| abstract_inverted_index.morphology | 67 |
| abstract_inverted_index.polymerase | 130 |
| abstract_inverted_index.pyroptosis | 173 |
| abstract_inverted_index.tomography | 48 |
| abstract_inverted_index.treatment. | 190 |
| abstract_inverted_index.Aβ-induced | 201 |
| abstract_inverted_index.components. | 177 |
| abstract_inverted_index.conclusion, | 222 |
| abstract_inverted_index.expression. | 203 |
| abstract_inverted_index.hematoxylin | 50 |
| abstract_inverted_index.microscopy. | 83 |
| abstract_inverted_index.Quantitative | 129 |
| abstract_inverted_index.inflammatory | 207 |
| abstract_inverted_index.necroptosis, | 171 |
| abstract_inverted_index.upregulation | 195 |
| abstract_inverted_index.Enzyme-linked | 84 |
| abstract_inverted_index.Morphological | 70 |
| abstract_inverted_index.immunosorbent | 85 |
| abstract_inverted_index.inflammation. | 110 |
| abstract_inverted_index.morphological | 219 |
| abstract_inverted_index.pathogenesis. | 235 |
| abstract_inverted_index.supernatants, | 98 |
| abstract_inverted_index.Aβ1-40-induced | 7, 163, 214, 224 |
| abstract_inverted_index.PANoptosis-like | 155, 228 |
| abstract_inverted_index.transcriptomics | 25 |
| abstract_inverted_index.AIM2-PANoptosome | 19, 176 |
| abstract_inverted_index.AIM2-PANoptosome. | 128 |
| abstract_inverted_index.PANoptosis-related | 197 |
| abstract_inverted_index.immunofluorescence | 193 |
| abstract_inverted_index.electroretinography | 56 |
| abstract_inverted_index.immunofluorescence, | 137 |
| abstract_inverted_index.CO-immunoprecipitation(CoIP) | 111 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.6800000071525574 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.13343429 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |