Investigation of the Urinary Peptidome to Unravel Collagen Degradation in Health and Kidney Disease Article Swipe
Ioanna K. Mina
,
Luis F. Iglesias‐Martinez
,
Matthias Ley
,
Lucas Fillinger
,
Paul Perco
,
Justyna Siwy
,
Harald Mischak
,
Vera Jankowski
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/pmic.202400279
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/pmic.202400279
Naturally occurring fragments of collagen type I alpha 1 chain (COL1A1) have been previously associated with chronic kidney disease (CKD), with some fragments showing positive and others negative associations. Using urinary peptidome data from healthy individuals ( n = 1131) and CKD patients ( n = 5585) this aspect was investigated in detail. Based on the hypothesis that many collagen peptides are derived not from the full, mature collagen molecule, but from (larger) collagen degradation products, relationships between COL1A1 peptides containing identical sequences were investigated, with the smaller (offspring) peptide being a possible degradation product of the larger (parent) one. The strongest correlations were found for relationships where the parent differed by a maximum of three amino acids from the offspring, indicating an exopeptidase‐regulated stepwise degradation process. Regression analysis indicated that CKD affects this degradation process. A comparison of matched CKD patients and control individuals ( n = 612 each) showed that peptides at the start of the degradation process were consistently downregulated in CKD, indicating an attenuation of COL1A1 endopeptidase‐mediated degradation. However, as these peptides undergo further degradation, likely mediated by exopeptidases, this downregulation can become less significant or even reverse, leading to an upregulation of later‐stage fragments and potentially explaining the inconsistencies observed in previous studies.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/pmic.202400279
- OA Status
- hybrid
- Cited By
- 8
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405953340
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405953340Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/pmic.202400279Digital Object Identifier
- Title
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Investigation of the Urinary Peptidome to Unravel Collagen Degradation in Health and Kidney DiseaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-12-30Full publication date if available
- Authors
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Ioanna K. Mina, Luis F. Iglesias‐Martinez, Matthias Ley, Lucas Fillinger, Paul Perco, Justyna Siwy, Harald Mischak, Vera JankowskiList of authors in order
- Landing page
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https://doi.org/10.1002/pmic.202400279Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1002/pmic.202400279Direct OA link when available
- Concepts
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Exopeptidase, Kidney disease, Degradation (telecommunications), Downregulation and upregulation, Urinary system, Protein degradation, Offspring, Internal medicine, Biology, Proteolysis, Chemistry, Amino acid, Biochemistry, Endocrinology, Medicine, Genetics, Enzyme, Pregnancy, Gene, Telecommunications, Computer scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8Per-year citation counts (last 5 years)
- References (count)
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58Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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