Investigation on the efficacy of a tissue equivalent material bolus for BNCT Article Swipe
Akinori Sasaki
,
Naonori Hu
,
Ryo Kakino
,
Mai Nojiri
,
Keiji Nihei
,
Teruhito Aihara
,
Satoshi Takeno
,
Yuki Yoshino
,
Hiroki Tanaka
,
Koji Ono
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/acm2.70287
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/acm2.70287
Background In radiation therapy, the use of bolus is an effective technique for improving the surface dose. This irradiation technique is also used in BNCT. However, since BNCT uses neutron irradiation, it is important to evaluate both the neutron moderation characteristic and the radioactivation of the bolus. Purpose This study aimed to evaluate the tissue equivalence and activation of commercially available boluses for use in BNCT. Methods Two types of commercially available boluses were evaluated. The boluses were placed on a water phantom and irradiated using the NeuCure BNCT system. Firstly, the tissue equivalency of the boluses was evaluated by comparing the experimentally measured thermal neutron flux and gamma‐ray distribution within the phantom, and the results were compared with simulation results. Secondly, the neutron activation of the boluses was assessed using an ionization chamber survey meter and an HP‐Ge semiconductor detector to identify the produced radionuclides. Results The thermal neutron flux and gamma ray distribution in the water phantom agreed well between the measured and simulated results. The study revealed that both boluses became radioactive after neutron irradiation, primarily due to the production of radionuclides such as 24 Na and 38 Cl. Conclusions While boluses are effective in improving surface dose in BNCT, their use also introduces the risk of patient exposure to radiation from radioactivated bolus materials. Therefore, careful selection of bolus materials with minimal radioactivation is crucial to ensure patient safety.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/acm2.70287
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acm2.70287
- OA Status
- gold
- Cited By
- 1
- References
- 22
- OpenAlex ID
- https://openalex.org/W4415056587
All OpenAlex metadata
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https://openalex.org/W4415056587Canonical identifier for this work in OpenAlex
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https://doi.org/10.1002/acm2.70287Digital Object Identifier
- Title
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Investigation on the efficacy of a tissue equivalent material bolus for BNCTWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-10-01Full publication date if available
- Authors
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Akinori Sasaki, Naonori Hu, Ryo Kakino, Mai Nojiri, Keiji Nihei, Teruhito Aihara, Satoshi Takeno, Yuki Yoshino, Hiroki Tanaka, Koji OnoList of authors in order
- Landing page
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https://doi.org/10.1002/acm2.70287Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acm2.70287Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acm2.70287Direct OA link when available
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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22Number of works referenced by this work
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