p53‐competent cells and p53‐deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicity Article Swipe
Dayton M. Petibone
,
Thikra Mustafa
,
Shawn E. Bourdo
,
Andersen Lafont
,
Wei Ding
,
Alokita Karmakar
,
Zeid A. Nima
,
Fumiya Watanabe
,
Daniel A. Casciano
,
Suzanne M. Morris
,
Vasily N. Dobrovolsky
,
Alexandru S. Biris
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1002/jat.3472
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1002/jat.3472
Due to the distinctive physical, electrical, and chemical properties of graphene nanomaterials, numerous efforts pursuing graphene‐based biomedical and industrial applications are underway. Oxidation of pristine graphene surfaces mitigates its otherwise hydrophobic characteristic thereby improving its biocompatibility and functionality. Yet, the potential widespread use of oxidized graphene derivatives raises concern about adverse impacts on human health. The p53 tumor suppressor protein maintains cellular and genetic stability after toxic exposures. Here, we show that p53 functional status correlates with oxygen functionalized graphene ( f‐G ) cytotoxicity and genotoxicity in vitro . The f‐G exposed p53 ‐competent cells, but not p53 ‐deficient cells, initiated G 0 /G 1 phase cell cycle arrest, suppressed reactive oxygen species, and entered apoptosis. There was p53‐dependent f‐G genotoxicity evident as increased structural chromosome damage, but not increased gene mutation or chromatin loss. In conclusion, the cytotoxic and genotoxic potential for f‐G in exposed cells was dependent on the p53 functional status. These findings have broad implications for the safe and effective implementation of oxidized graphene derivatives into biomedical and industrial applications. Published 2017. This article has been contributed to by US Government employees and their work is in the public domain in the USA.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/jat.3472
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.3472
- OA Status
- hybrid
- Cited By
- 13
- References
- 75
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2607148789
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2607148789Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/jat.3472Digital Object Identifier
- Title
-
p53‐competent cells and p53‐deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-04-20Full publication date if available
- Authors
-
Dayton M. Petibone, Thikra Mustafa, Shawn E. Bourdo, Andersen Lafont, Wei Ding, Alokita Karmakar, Zeid A. Nima, Fumiya Watanabe, Daniel A. Casciano, Suzanne M. Morris, Vasily N. Dobrovolsky, Alexandru S. BirisList of authors in order
- Landing page
-
https://doi.org/10.1002/jat.3472Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.3472Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.3472Direct OA link when available
- Concepts
-
Genotoxicity, Graphene, Cytotoxicity, Reactive oxygen species, Apoptosis, DNA damage, Biocompatibility, Chemistry, Cytotoxic T cell, Cell biology, Nanotechnology, Biology, Toxicity, Materials science, In vitro, Biochemistry, DNA, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
13Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 1, 2022: 2, 2020: 4, 2019: 2Per-year citation counts (last 5 years)
- References (count)
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75Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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