RAS mutation and associated risk of malignancy in the thyroid gland: An FNA study with cytology‐histology correlation Article Swipe
Syed M. Gilani
,
Rita Abi‐Raad
,
James Garritano
,
Guoping Cai
,
Manju L. Prasad
,
Adebowale Adeniran
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1002/cncy.22537
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1002/cncy.22537
Background Activating point mutations of the RAS gene ( NRAS , HRAS , and KRAS ) can be seen in benign and malignant thyroid tumors; among these, NRAS mutations are more commonly seen. This study was conducted to evaluate the thyroid risk of malignancy (ROM) associated with RAS mutations in thyroid fine‐needle aspiration (FNA) at the authors' institution. Methods The authors searched their electronic database system between January 2015 and May 2021 for thyroid FNA cases with any type of RAS mutation. Molecular alterations were identified with the ThyroSeq Genomic Classifier, ThyGeNEXT (thyroid oncogene panel)/ThyraMIR (miRNA classifier), or ThyroSure gene panel. Results A total of 127 cases (age, 51 ± 14 years; 100 females and 27 males) were identified, and 72 had histologic follow‐up. The overall ROM associated with RAS mutations (with or without any other molecular alterations) was 29%, whereas the ROM was lower (18%) with RAS mutations only. Isolated NRAS , HRAS , and KRAS mutation–associated ROMs were 15%, 27%, and 14%, respectively. Among these RAS ‐mutated cases, the cases with a Bethesda category IV cytologic diagnosis had a higher ROM than the cases with a category III diagnosis (38% vs 17%). Twenty‐one histologically confirmed malignant cases were mostly classified on cytology as category IV lesions (14 of 34; 41%), and the remainder were either category III (6 of 35; 17%) or V lesions (1 of 1; 100%). Conclusions This study demonstrated that the overall RAS mutation–associated ROM in thyroid FNA was intermediate (29%), and isolated HRAS mutations appeared to have a higher ROM (27%) than NRAS and KRAS mutations (15% and 14%, respectively).
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- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/cncy.22537
- OA Status
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- Cited By
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3215893820Canonical identifier for this work in OpenAlex
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https://doi.org/10.1002/cncy.22537Digital Object Identifier
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RAS mutation and associated risk of malignancy in the thyroid gland: An FNA study with cytology‐histology correlationWork title
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articleOpenAlex work type
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enPrimary language
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2021Year of publication
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2021-11-30Full publication date if available
- Authors
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Syed M. Gilani, Rita Abi‐Raad, James Garritano, Guoping Cai, Manju L. Prasad, Adebowale AdeniranList of authors in order
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https://doi.org/10.1002/cncy.22537Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/9467821Direct OA link when available
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Medicine, Cytology, Histology, Malignancy, Thyroid, Pathology, Internal medicine, Radiology, OncologyTop concepts (fields/topics) attached by OpenAlex
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27Total citation count in OpenAlex
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2025: 4, 2024: 13, 2023: 6, 2022: 3, 2021: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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