IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis Article Swipe
Li Liang
,
Fengmei Zhang
,
Naibo Feng
,
Biao Kuang
,
Mengtian Fan
,
Cheng Chen
,
Yiming Pan
,
Pengfei Zhou
,
Nana Geng
,
Xingyue Li
,
Menglin Xian
,
Linhong Deng
,
Xiaoli Li
,
Liang Kuang
,
Fengtao Luo
,
Qiaoyan Tan
,
Yangli Xie
,
Fengjin Guo
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1038/s12276-023-01106-w
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1038/s12276-023-01106-w
Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due to its disabling and pain-causing properties. ER stress has been reported to be closely related to the progression of OA. The inositol-requiring enzyme 1α/X-box-binding protein-1 spliced (IRE1α/XBP1s) pathway, which is highly expressed in the chondrocytes of OA patients, promotes the degradation and refolding of abnormal proteins during ER stress and maintains the stability of the ER environment of chondrocytes, but its function and the underlying mechanisms of how it contributes to the progression of OA remain unclear. This study investigates the role of IRE1α/ ERN1 in OA. Specific deficiency of ERN1 in chondrocytes spontaneously resulted in OA-like cartilage destruction and accelerated OA progression in a surgically induced arthritis model. Local delivery of Ad ERN1 relieved degradation of the cartilage matrix and prevented OA development in an ACLT-mediated model. Mechanistically, progranulin (PGRN), an intracellular chaperone, binds to IRE1α, promoting its phosphorylation and splicing of XBP1u to generate XBP1s. XBP1s protects articular cartilage through TNF-α/ERK1/2 signaling and further maintains collagen homeostasis by regulating type II collagen expression. The chondroprotective effect of IRE1α/ ERN1 is dependent on PGRN and XBP1s splicing. ERN1 deficiency accelerated cartilage degeneration in OA by reducing PGRN expression and XBP1s splicing, subsequently decreasing collagen II expression and triggering collagen structural abnormalities and an imbalance in collagen homeostasis. This study provides new insights into OA pathogenesis and the UPR and suggests that IRE1α/ ERN1 may serve as a potential target for the treatment of joint degenerative diseases, including OA.
Related Topics
Concepts
Unfolded protein response
XBP1
Homeostasis
Cell biology
Cartilage
Osteoarthritis
Cancer research
Phosphorylation
Alternative splicing
RNA splicing
Medicine
Chemistry
Biology
Endoplasmic reticulum
Pathology
Messenger RNA
Biochemistry
Anatomy
Alternative medicine
Gene
RNA
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s12276-023-01106-w
- https://www.nature.com/articles/s12276-023-01106-w.pdf
- OA Status
- gold
- Cited By
- 10
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4388086360
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4388086360Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s12276-023-01106-wDigital Object Identifier
- Title
-
IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-11-01Full publication date if available
- Authors
-
Li Liang, Fengmei Zhang, Naibo Feng, Biao Kuang, Mengtian Fan, Cheng Chen, Yiming Pan, Pengfei Zhou, Nana Geng, Xingyue Li, Menglin Xian, Linhong Deng, Xiaoli Li, Liang Kuang, Fengtao Luo, Qiaoyan Tan, Yangli Xie, Fengjin GuoList of authors in order
- Landing page
-
https://doi.org/10.1038/s12276-023-01106-wPublisher landing page
- PDF URL
-
https://www.nature.com/articles/s12276-023-01106-w.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s12276-023-01106-w.pdfDirect OA link when available
- Concepts
-
Unfolded protein response, XBP1, Homeostasis, Cell biology, Cartilage, Osteoarthritis, Cancer research, Phosphorylation, Alternative splicing, RNA splicing, Medicine, Chemistry, Biology, Endoplasmic reticulum, Pathology, Messenger RNA, Biochemistry, Anatomy, Alternative medicine, Gene, RNATop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 3Per-year citation counts (last 5 years)
- References (count)
-
52Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4388086360 |
|---|---|
| doi | https://doi.org/10.1038/s12276-023-01106-w |
| ids.doi | https://doi.org/10.1038/s12276-023-01106-w |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/37907740 |
| ids.openalex | https://openalex.org/W4388086360 |
| fwci | 3.77897551 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000235 |
| mesh[1].descriptor_ui | D017346 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | genetics |
| mesh[1].descriptor_name | Protein Serine-Threonine Kinases |
| mesh[2].qualifier_ui | Q000378 |
| mesh[2].descriptor_ui | D017346 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | metabolism |
| mesh[2].descriptor_name | Protein Serine-Threonine Kinases |
| mesh[3].qualifier_ui | Q000378 |
| mesh[3].descriptor_ui | D000077153 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | metabolism |
| mesh[3].descriptor_name | Progranulins |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D004722 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | Endoribonucleases |
| mesh[5].qualifier_ui | Q000378 |
| mesh[5].descriptor_ui | D004722 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | metabolism |
| mesh[5].descriptor_name | Endoribonucleases |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D011788 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Quality of Life |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D010003 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Osteoarthritis |
| mesh[8].qualifier_ui | Q000378 |
| mesh[8].descriptor_ui | D019902 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | metabolism |
| mesh[8].descriptor_name | Chondrocytes |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D002358 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Cartilage, Articular |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D003094 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | Collagen |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D006706 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Homeostasis |
| mesh[12].qualifier_ui | Q000235 |
| mesh[12].descriptor_ui | D000071717 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | genetics |
| mesh[12].descriptor_name | X-Box Binding Protein 1 |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D000071717 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | X-Box Binding Protein 1 |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D006801 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Humans |
| mesh[15].qualifier_ui | Q000235 |
| mesh[15].descriptor_ui | D017346 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | genetics |
| mesh[15].descriptor_name | Protein Serine-Threonine Kinases |
| mesh[16].qualifier_ui | Q000378 |
| mesh[16].descriptor_ui | D017346 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | metabolism |
| mesh[16].descriptor_name | Protein Serine-Threonine Kinases |
| mesh[17].qualifier_ui | Q000378 |
| mesh[17].descriptor_ui | D000077153 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | metabolism |
| mesh[17].descriptor_name | Progranulins |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D004722 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | Endoribonucleases |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D004722 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Endoribonucleases |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D011788 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Quality of Life |
| mesh[21].qualifier_ui | Q000378 |
| mesh[21].descriptor_ui | D010003 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | metabolism |
| mesh[21].descriptor_name | Osteoarthritis |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D019902 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | Chondrocytes |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D002358 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | Cartilage, Articular |
| mesh[24].qualifier_ui | Q000378 |
| mesh[24].descriptor_ui | D003094 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | metabolism |
| mesh[24].descriptor_name | Collagen |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D006706 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Homeostasis |
| mesh[26].qualifier_ui | Q000235 |
| mesh[26].descriptor_ui | D000071717 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | genetics |
| mesh[26].descriptor_name | X-Box Binding Protein 1 |
| mesh[27].qualifier_ui | Q000378 |
| mesh[27].descriptor_ui | D000071717 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | metabolism |
| mesh[27].descriptor_name | X-Box Binding Protein 1 |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D006801 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Humans |
| mesh[29].qualifier_ui | Q000235 |
| mesh[29].descriptor_ui | D017346 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | genetics |
| mesh[29].descriptor_name | Protein Serine-Threonine Kinases |
| mesh[30].qualifier_ui | Q000378 |
| mesh[30].descriptor_ui | D017346 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | metabolism |
| mesh[30].descriptor_name | Protein Serine-Threonine Kinases |
| mesh[31].qualifier_ui | Q000378 |
| mesh[31].descriptor_ui | D000077153 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | metabolism |
| mesh[31].descriptor_name | Progranulins |
| mesh[32].qualifier_ui | Q000235 |
| mesh[32].descriptor_ui | D004722 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | genetics |
| mesh[32].descriptor_name | Endoribonucleases |
| mesh[33].qualifier_ui | Q000378 |
| mesh[33].descriptor_ui | D004722 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | metabolism |
| mesh[33].descriptor_name | Endoribonucleases |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D011788 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Quality of Life |
| mesh[35].qualifier_ui | Q000378 |
| mesh[35].descriptor_ui | D010003 |
| mesh[35].is_major_topic | True |
| mesh[35].qualifier_name | metabolism |
| mesh[35].descriptor_name | Osteoarthritis |
| mesh[36].qualifier_ui | Q000378 |
| mesh[36].descriptor_ui | D019902 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | metabolism |
| mesh[36].descriptor_name | Chondrocytes |
| mesh[37].qualifier_ui | Q000378 |
| mesh[37].descriptor_ui | D002358 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | metabolism |
| mesh[37].descriptor_name | Cartilage, Articular |
| mesh[38].qualifier_ui | Q000378 |
| mesh[38].descriptor_ui | D003094 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | metabolism |
| mesh[38].descriptor_name | Collagen |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D006706 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Homeostasis |
| mesh[40].qualifier_ui | Q000235 |
| mesh[40].descriptor_ui | D000071717 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | genetics |
| mesh[40].descriptor_name | X-Box Binding Protein 1 |
| mesh[41].qualifier_ui | Q000378 |
| mesh[41].descriptor_ui | D000071717 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | metabolism |
| mesh[41].descriptor_name | X-Box Binding Protein 1 |
| type | article |
| title | IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis |
| awards[0].id | https://openalex.org/G4022496166 |
| awards[0].funder_id | https://openalex.org/F4320321001 |
| awards[0].display_name | |
| awards[0].funder_award_id | No.82272550 |
| awards[0].funder_display_name | National Natural Science Foundation of China |
| awards[1].id | https://openalex.org/G6366480911 |
| awards[1].funder_id | https://openalex.org/F4320321001 |
| awards[1].display_name | |
| awards[1].funder_award_id | No.81871769 |
| awards[1].funder_display_name | National Natural Science Foundation of China |
| awards[2].id | https://openalex.org/G1173647927 |
| awards[2].funder_id | https://openalex.org/F4320321543 |
| awards[2].display_name | |
| awards[2].funder_award_id | No. 2021M700632 |
| awards[2].funder_display_name | China Postdoctoral Science Foundation |
| awards[3].id | https://openalex.org/G7961673671 |
| awards[3].funder_id | https://openalex.org/F4320313612 |
| awards[3].display_name | |
| awards[3].funder_award_id | No. 2020-379-46 |
| awards[3].funder_display_name | Chongqing Postdoctoral Science Foundation |
| biblio.issue | 11 |
| biblio.volume | 55 |
| biblio.last_page | 2389 |
| biblio.first_page | 2376 |
| topics[0].id | https://openalex.org/T11282 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9954000115394592 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2738 |
| topics[0].subfield.display_name | Psychiatry and Mental health |
| topics[0].display_name | Fibromyalgia and Chronic Fatigue Syndrome Research |
| topics[1].id | https://openalex.org/T11150 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9861999750137329 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1307 |
| topics[1].subfield.display_name | Cell Biology |
| topics[1].display_name | Endoplasmic Reticulum Stress and Disease |
| topics[2].id | https://openalex.org/T10855 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9829999804496765 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2728 |
| topics[2].subfield.display_name | Neurology |
| topics[2].display_name | Amyotrophic Lateral Sclerosis Research |
| funders[0].id | https://openalex.org/F4320313612 |
| funders[0].ror | |
| funders[0].display_name | Chongqing Postdoctoral Science Foundation |
| funders[1].id | https://openalex.org/F4320321001 |
| funders[1].ror | https://ror.org/01h0zpd94 |
| funders[1].display_name | National Natural Science Foundation of China |
| funders[2].id | https://openalex.org/F4320321543 |
| funders[2].ror | https://ror.org/0426zh255 |
| funders[2].display_name | China Postdoctoral Science Foundation |
| is_xpac | False |
| apc_list.value | 2690 |
| apc_list.currency | GBP |
| apc_list.value_usd | 3299 |
| apc_paid.value | 2690 |
| apc_paid.currency | GBP |
| apc_paid.value_usd | 3299 |
| concepts[0].id | https://openalex.org/C139447449 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7121829390525818 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q14633900 |
| concepts[0].display_name | Unfolded protein response |
| concepts[1].id | https://openalex.org/C2781331208 |
| concepts[1].level | 5 |
| concepts[1].score | 0.7067757844924927 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q18032378 |
| concepts[1].display_name | XBP1 |
| concepts[2].id | https://openalex.org/C63645605 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5531389713287354 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q103191 |
| concepts[2].display_name | Homeostasis |
| concepts[3].id | https://openalex.org/C95444343 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5134254693984985 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[3].display_name | Cell biology |
| concepts[4].id | https://openalex.org/C2780550940 |
| concepts[4].level | 2 |
| concepts[4].score | 0.45366910099983215 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q502730 |
| concepts[4].display_name | Cartilage |
| concepts[5].id | https://openalex.org/C2776164576 |
| concepts[5].level | 3 |
| concepts[5].score | 0.43938153982162476 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q62736 |
| concepts[5].display_name | Osteoarthritis |
| concepts[6].id | https://openalex.org/C502942594 |
| concepts[6].level | 1 |
| concepts[6].score | 0.43669548630714417 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[6].display_name | Cancer research |
| concepts[7].id | https://openalex.org/C11960822 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4243730902671814 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q242736 |
| concepts[7].display_name | Phosphorylation |
| concepts[8].id | https://openalex.org/C194583182 |
| concepts[8].level | 4 |
| concepts[8].score | 0.4172988533973694 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q21114084 |
| concepts[8].display_name | Alternative splicing |
| concepts[9].id | https://openalex.org/C54458228 |
| concepts[9].level | 4 |
| concepts[9].score | 0.387986958026886 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q237218 |
| concepts[9].display_name | RNA splicing |
| concepts[10].id | https://openalex.org/C71924100 |
| concepts[10].level | 0 |
| concepts[10].score | 0.38376015424728394 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[10].display_name | Medicine |
| concepts[11].id | https://openalex.org/C185592680 |
| concepts[11].level | 0 |
| concepts[11].score | 0.3750479519367218 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[11].display_name | Chemistry |
| concepts[12].id | https://openalex.org/C86803240 |
| concepts[12].level | 0 |
| concepts[12].score | 0.2722623944282532 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[12].display_name | Biology |
| concepts[13].id | https://openalex.org/C158617107 |
| concepts[13].level | 2 |
| concepts[13].score | 0.22264069318771362 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q79927 |
| concepts[13].display_name | Endoplasmic reticulum |
| concepts[14].id | https://openalex.org/C142724271 |
| concepts[14].level | 1 |
| concepts[14].score | 0.20965370535850525 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[14].display_name | Pathology |
| concepts[15].id | https://openalex.org/C105580179 |
| concepts[15].level | 3 |
| concepts[15].score | 0.1425417959690094 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q188928 |
| concepts[15].display_name | Messenger RNA |
| concepts[16].id | https://openalex.org/C55493867 |
| concepts[16].level | 1 |
| concepts[16].score | 0.10949543118476868 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[16].display_name | Biochemistry |
| concepts[17].id | https://openalex.org/C105702510 |
| concepts[17].level | 1 |
| concepts[17].score | 0.08917239308357239 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q514 |
| concepts[17].display_name | Anatomy |
| concepts[18].id | https://openalex.org/C204787440 |
| concepts[18].level | 2 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q188504 |
| concepts[18].display_name | Alternative medicine |
| concepts[19].id | https://openalex.org/C104317684 |
| concepts[19].level | 2 |
| concepts[19].score | 0.0 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[19].display_name | Gene |
| concepts[20].id | https://openalex.org/C67705224 |
| concepts[20].level | 3 |
| concepts[20].score | 0.0 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q11053 |
| concepts[20].display_name | RNA |
| keywords[0].id | https://openalex.org/keywords/unfolded-protein-response |
| keywords[0].score | 0.7121829390525818 |
| keywords[0].display_name | Unfolded protein response |
| keywords[1].id | https://openalex.org/keywords/xbp1 |
| keywords[1].score | 0.7067757844924927 |
| keywords[1].display_name | XBP1 |
| keywords[2].id | https://openalex.org/keywords/homeostasis |
| keywords[2].score | 0.5531389713287354 |
| keywords[2].display_name | Homeostasis |
| keywords[3].id | https://openalex.org/keywords/cell-biology |
| keywords[3].score | 0.5134254693984985 |
| keywords[3].display_name | Cell biology |
| keywords[4].id | https://openalex.org/keywords/cartilage |
| keywords[4].score | 0.45366910099983215 |
| keywords[4].display_name | Cartilage |
| keywords[5].id | https://openalex.org/keywords/osteoarthritis |
| keywords[5].score | 0.43938153982162476 |
| keywords[5].display_name | Osteoarthritis |
| keywords[6].id | https://openalex.org/keywords/cancer-research |
| keywords[6].score | 0.43669548630714417 |
| keywords[6].display_name | Cancer research |
| keywords[7].id | https://openalex.org/keywords/phosphorylation |
| keywords[7].score | 0.4243730902671814 |
| keywords[7].display_name | Phosphorylation |
| keywords[8].id | https://openalex.org/keywords/alternative-splicing |
| keywords[8].score | 0.4172988533973694 |
| keywords[8].display_name | Alternative splicing |
| keywords[9].id | https://openalex.org/keywords/rna-splicing |
| keywords[9].score | 0.387986958026886 |
| keywords[9].display_name | RNA splicing |
| keywords[10].id | https://openalex.org/keywords/medicine |
| keywords[10].score | 0.38376015424728394 |
| keywords[10].display_name | Medicine |
| keywords[11].id | https://openalex.org/keywords/chemistry |
| keywords[11].score | 0.3750479519367218 |
| keywords[11].display_name | Chemistry |
| keywords[12].id | https://openalex.org/keywords/biology |
| keywords[12].score | 0.2722623944282532 |
| keywords[12].display_name | Biology |
| keywords[13].id | https://openalex.org/keywords/endoplasmic-reticulum |
| keywords[13].score | 0.22264069318771362 |
| keywords[13].display_name | Endoplasmic reticulum |
| keywords[14].id | https://openalex.org/keywords/pathology |
| keywords[14].score | 0.20965370535850525 |
| keywords[14].display_name | Pathology |
| keywords[15].id | https://openalex.org/keywords/messenger-rna |
| keywords[15].score | 0.1425417959690094 |
| keywords[15].display_name | Messenger RNA |
| keywords[16].id | https://openalex.org/keywords/biochemistry |
| keywords[16].score | 0.10949543118476868 |
| keywords[16].display_name | Biochemistry |
| keywords[17].id | https://openalex.org/keywords/anatomy |
| keywords[17].score | 0.08917239308357239 |
| keywords[17].display_name | Anatomy |
| language | en |
| locations[0].id | doi:10.1038/s12276-023-01106-w |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S57588113 |
| locations[0].source.issn | 1226-3613, 2092-6413 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1226-3613 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Experimental & Molecular Medicine |
| locations[0].source.host_organization | https://openalex.org/P4310319965 |
| locations[0].source.host_organization_name | Springer Nature |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319965 |
| locations[0].source.host_organization_lineage_names | Springer Nature |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.nature.com/articles/s12276-023-01106-w.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Experimental & Molecular Medicine |
| locations[0].landing_page_url | https://doi.org/10.1038/s12276-023-01106-w |
| locations[1].id | pmid:37907740 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Experimental & molecular medicine |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/37907740 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10689778 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10689778/pdf/12276_2023_Article_1106.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Exp Mol Med |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10689778 |
| locations[3].id | pmh:oai:doaj.org/article:eab01dc3044e46f092e390b771dbe2cc |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Experimental and Molecular Medicine, Vol 55, Iss 11, Pp 2376-2389 (2023) |
| locations[3].landing_page_url | https://doaj.org/article/eab01dc3044e46f092e390b771dbe2cc |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5100718184 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-5302-2754 |
| authorships[0].author.display_name | Li Liang |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[0].affiliations[0].raw_affiliation_string | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[0].institutions[0].id | https://openalex.org/I87780372 |
| authorships[0].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Chongqing Medical University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Li Liang |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[1].author.id | https://openalex.org/A5108080084 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-9456-9243 |
| authorships[1].author.display_name | Fengmei Zhang |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[1].affiliations[0].raw_affiliation_string | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[1].institutions[0].id | https://openalex.org/I87780372 |
| authorships[1].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Chongqing Medical University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Fengmei Zhang |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[2].author.id | https://openalex.org/A5022302212 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-6426-2411 |
| authorships[2].author.display_name | Naibo Feng |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[2].affiliations[0].raw_affiliation_string | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[2].institutions[0].id | https://openalex.org/I87780372 |
| authorships[2].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Chongqing Medical University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Naibo Feng |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[3].author.id | https://openalex.org/A5021826825 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-5787-9480 |
| authorships[3].author.display_name | Biao Kuang |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Orthopedics, The 2nd Affiliated Hospital of Chongqing Medical University, 400072, Chongqing, China |
| authorships[3].institutions[0].id | https://openalex.org/I87780372 |
| authorships[3].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Chongqing Medical University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Biao Kuang |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Orthopedics, The 2nd Affiliated Hospital of Chongqing Medical University, 400072, Chongqing, China |
| authorships[4].author.id | https://openalex.org/A5101181216 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Mengtian Fan |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[4].affiliations[0].raw_affiliation_string | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[4].institutions[0].id | https://openalex.org/I87780372 |
| authorships[4].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Chongqing Medical University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Mengtian Fan |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[5].author.id | https://openalex.org/A5101870186 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-4819-7212 |
| authorships[5].author.display_name | Cheng Chen |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Orthopedics, The 1st Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China |
| authorships[5].institutions[0].id | https://openalex.org/I87780372 |
| authorships[5].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Chongqing Medical University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Cheng Chen |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Orthopedics, The 1st Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China |
| authorships[6].author.id | https://openalex.org/A5021179110 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Yiming Pan |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[6].affiliations[0].raw_affiliation_string | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[6].institutions[0].id | https://openalex.org/I87780372 |
| authorships[6].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Chongqing Medical University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Yiming Pan |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[7].author.id | https://openalex.org/A5101569329 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-7741-7785 |
| authorships[7].author.display_name | Pengfei Zhou |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210128042, https://openalex.org/I87780372 |
| authorships[7].affiliations[0].raw_affiliation_string | Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, College of Stomatology, Chongqing Medical University, 400016, Chongqing, China |
| authorships[7].institutions[0].id | https://openalex.org/I87780372 |
| authorships[7].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Chongqing Medical University |
| authorships[7].institutions[1].id | https://openalex.org/I4210128042 |
| authorships[7].institutions[1].ror | https://ror.org/02bnr5073 |
| authorships[7].institutions[1].type | healthcare |
| authorships[7].institutions[1].lineage | https://openalex.org/I4210128042 |
| authorships[7].institutions[1].country_code | CN |
| authorships[7].institutions[1].display_name | Stomatological Hospital of Chongqing Medical University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Pengfei Zhou |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, College of Stomatology, Chongqing Medical University, 400016, Chongqing, China |
| authorships[8].author.id | https://openalex.org/A5010596460 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Nana Geng |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[8].affiliations[0].raw_affiliation_string | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[8].institutions[0].id | https://openalex.org/I87780372 |
| authorships[8].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Chongqing Medical University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Nana Geng |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[9].author.id | https://openalex.org/A5007225360 |
| authorships[9].author.orcid | https://orcid.org/0009-0000-4455-7802 |
| authorships[9].author.display_name | Xingyue Li |
| authorships[9].countries | CN |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[9].affiliations[0].raw_affiliation_string | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[9].institutions[0].id | https://openalex.org/I87780372 |
| authorships[9].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[9].institutions[0].country_code | CN |
| authorships[9].institutions[0].display_name | Chongqing Medical University |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Xingyue Li |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[10].author.id | https://openalex.org/A5073535002 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Menglin Xian |
| authorships[10].countries | CN |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[10].affiliations[0].raw_affiliation_string | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[10].institutions[0].id | https://openalex.org/I87780372 |
| authorships[10].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[10].institutions[0].country_code | CN |
| authorships[10].institutions[0].display_name | Chongqing Medical University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Menglin Xian |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[11].author.id | https://openalex.org/A5100604591 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-1970-8239 |
| authorships[11].author.display_name | Linhong Deng |
| authorships[11].countries | CN |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[11].affiliations[0].raw_affiliation_string | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[11].institutions[0].id | https://openalex.org/I87780372 |
| authorships[11].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[11].institutions[0].country_code | CN |
| authorships[11].institutions[0].display_name | Chongqing Medical University |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Lin Deng |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[12].author.id | https://openalex.org/A5100418692 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-1359-5130 |
| authorships[12].author.display_name | Xiaoli Li |
| authorships[12].countries | CN |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[12].affiliations[0].raw_affiliation_string | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[12].institutions[0].id | https://openalex.org/I87780372 |
| authorships[12].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[12].institutions[0].country_code | CN |
| authorships[12].institutions[0].display_name | Chongqing Medical University |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Xiaoli Li |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[13].author.id | https://openalex.org/A5114044874 |
| authorships[13].author.orcid | |
| authorships[13].author.display_name | Liang Kuang |
| authorships[13].countries | CN |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I151075929, https://openalex.org/I4210092099 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair (CBMR), State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University, 400042, Chongqing, China |
| authorships[13].institutions[0].id | https://openalex.org/I151075929 |
| authorships[13].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[13].institutions[0].country_code | CN |
| authorships[13].institutions[0].display_name | Army Medical University |
| authorships[13].institutions[1].id | https://openalex.org/I4210092099 |
| authorships[13].institutions[1].ror | https://ror.org/00fthae95 |
| authorships[13].institutions[1].type | healthcare |
| authorships[13].institutions[1].lineage | https://openalex.org/I4210092099 |
| authorships[13].institutions[1].country_code | CN |
| authorships[13].institutions[1].display_name | Daping Hospital |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Liang Kuang |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair (CBMR), State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University, 400042, Chongqing, China |
| authorships[14].author.id | https://openalex.org/A5083321020 |
| authorships[14].author.orcid | https://orcid.org/0000-0001-6964-6967 |
| authorships[14].author.display_name | Fengtao Luo |
| authorships[14].countries | CN |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I151075929, https://openalex.org/I4210092099 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair (CBMR), State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University, 400042, Chongqing, China |
| authorships[14].institutions[0].id | https://openalex.org/I151075929 |
| authorships[14].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[14].institutions[0].country_code | CN |
| authorships[14].institutions[0].display_name | Army Medical University |
| authorships[14].institutions[1].id | https://openalex.org/I4210092099 |
| authorships[14].institutions[1].ror | https://ror.org/00fthae95 |
| authorships[14].institutions[1].type | healthcare |
| authorships[14].institutions[1].lineage | https://openalex.org/I4210092099 |
| authorships[14].institutions[1].country_code | CN |
| authorships[14].institutions[1].display_name | Daping Hospital |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Fengtao Luo |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair (CBMR), State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University, 400042, Chongqing, China |
| authorships[15].author.id | https://openalex.org/A5014297196 |
| authorships[15].author.orcid | |
| authorships[15].author.display_name | Qiaoyan Tan |
| authorships[15].countries | CN |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I151075929, https://openalex.org/I4210092099 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair (CBMR), State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University, 400042, Chongqing, China |
| authorships[15].institutions[0].id | https://openalex.org/I151075929 |
| authorships[15].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[15].institutions[0].country_code | CN |
| authorships[15].institutions[0].display_name | Army Medical University |
| authorships[15].institutions[1].id | https://openalex.org/I4210092099 |
| authorships[15].institutions[1].ror | https://ror.org/00fthae95 |
| authorships[15].institutions[1].type | healthcare |
| authorships[15].institutions[1].lineage | https://openalex.org/I4210092099 |
| authorships[15].institutions[1].country_code | CN |
| authorships[15].institutions[1].display_name | Daping Hospital |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Qiaoyan Tan |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair (CBMR), State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University, 400042, Chongqing, China |
| authorships[16].author.id | https://openalex.org/A5101401359 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-2865-1126 |
| authorships[16].author.display_name | Yangli Xie |
| authorships[16].countries | CN |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I151075929, https://openalex.org/I4210092099 |
| authorships[16].affiliations[0].raw_affiliation_string | Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair (CBMR), State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University, 400042, Chongqing, China |
| authorships[16].institutions[0].id | https://openalex.org/I151075929 |
| authorships[16].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[16].institutions[0].country_code | CN |
| authorships[16].institutions[0].display_name | Army Medical University |
| authorships[16].institutions[1].id | https://openalex.org/I4210092099 |
| authorships[16].institutions[1].ror | https://ror.org/00fthae95 |
| authorships[16].institutions[1].type | healthcare |
| authorships[16].institutions[1].lineage | https://openalex.org/I4210092099 |
| authorships[16].institutions[1].country_code | CN |
| authorships[16].institutions[1].display_name | Daping Hospital |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Yangli Xie |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair (CBMR), State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University, 400042, Chongqing, China |
| authorships[17].author.id | https://openalex.org/A5019033396 |
| authorships[17].author.orcid | https://orcid.org/0000-0002-7414-6585 |
| authorships[17].author.display_name | Fengjin Guo |
| authorships[17].countries | CN |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[17].affiliations[0].raw_affiliation_string | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| authorships[17].institutions[0].id | https://openalex.org/I87780372 |
| authorships[17].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[17].institutions[0].country_code | CN |
| authorships[17].institutions[0].display_name | Chongqing Medical University |
| authorships[17].author_position | last |
| authorships[17].raw_author_name | Fengjin Guo |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.nature.com/articles/s12276-023-01106-w.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11282 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9954000115394592 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2738 |
| primary_topic.subfield.display_name | Psychiatry and Mental health |
| primary_topic.display_name | Fibromyalgia and Chronic Fatigue Syndrome Research |
| related_works | https://openalex.org/W2986473802, https://openalex.org/W1994422443, https://openalex.org/W787120501, https://openalex.org/W625755886, https://openalex.org/W2052034388, https://openalex.org/W2054541170, https://openalex.org/W2961368723, https://openalex.org/W2070949249, https://openalex.org/W1997017455, https://openalex.org/W1986045624 |
| cited_by_count | 10 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 7 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 3 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1038/s12276-023-01106-w |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S57588113 |
| best_oa_location.source.issn | 1226-3613, 2092-6413 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1226-3613 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Experimental & Molecular Medicine |
| best_oa_location.source.host_organization | https://openalex.org/P4310319965 |
| best_oa_location.source.host_organization_name | Springer Nature |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319965 |
| best_oa_location.source.host_organization_lineage_names | Springer Nature |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.nature.com/articles/s12276-023-01106-w.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Experimental & Molecular Medicine |
| best_oa_location.landing_page_url | https://doi.org/10.1038/s12276-023-01106-w |
| primary_location.id | doi:10.1038/s12276-023-01106-w |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S57588113 |
| primary_location.source.issn | 1226-3613, 2092-6413 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1226-3613 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Experimental & Molecular Medicine |
| primary_location.source.host_organization | https://openalex.org/P4310319965 |
| primary_location.source.host_organization_name | Springer Nature |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319965 |
| primary_location.source.host_organization_lineage_names | Springer Nature |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.nature.com/articles/s12276-023-01106-w.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Experimental & Molecular Medicine |
| primary_location.landing_page_url | https://doi.org/10.1038/s12276-023-01106-w |
| publication_date | 2023-11-01 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W4241086090, https://openalex.org/W2762429861, https://openalex.org/W1988530401, https://openalex.org/W4210995681, https://openalex.org/W2604174049, https://openalex.org/W2252208090, https://openalex.org/W2016131399, https://openalex.org/W1573553557, https://openalex.org/W3030834164, https://openalex.org/W1903866035, https://openalex.org/W1678102090, https://openalex.org/W2149026101, https://openalex.org/W3216020325, https://openalex.org/W1901580941, https://openalex.org/W2047251679, https://openalex.org/W3201668563, https://openalex.org/W3184664738, https://openalex.org/W4200531872, https://openalex.org/W3007541218, https://openalex.org/W2411087228, https://openalex.org/W2776101720, https://openalex.org/W2089198803, https://openalex.org/W2159466552, https://openalex.org/W2003096043, https://openalex.org/W2608899726, https://openalex.org/W2109118586, https://openalex.org/W2937578637, https://openalex.org/W2921539094, https://openalex.org/W2801441229, https://openalex.org/W2099662390, https://openalex.org/W2901264708, https://openalex.org/W2500289352, https://openalex.org/W2575028522, https://openalex.org/W4283320554, https://openalex.org/W1101293327, https://openalex.org/W4282592063, https://openalex.org/W2990111539, https://openalex.org/W2970551180, https://openalex.org/W3024482887, https://openalex.org/W2911512153, https://openalex.org/W1971098111, https://openalex.org/W2085865745, https://openalex.org/W2535380444, https://openalex.org/W2050705743, https://openalex.org/W2606998714, https://openalex.org/W2339065539, https://openalex.org/W2091070005, https://openalex.org/W2897819547, https://openalex.org/W2700652066, https://openalex.org/W2169306311, https://openalex.org/W2134277117, https://openalex.org/W4226328551 |
| referenced_works_count | 52 |
| abstract_inverted_index.a | 4, 125, 248 |
| abstract_inverted_index.Ad | 133 |
| abstract_inverted_index.ER | 27, 68, 76 |
| abstract_inverted_index.II | 183, 216 |
| abstract_inverted_index.OA | 57, 95, 122, 143, 205, 235 |
| abstract_inverted_index.an | 146, 152, 224 |
| abstract_inverted_index.as | 247 |
| abstract_inverted_index.be | 33 |
| abstract_inverted_index.by | 180, 206 |
| abstract_inverted_index.in | 53, 106, 112, 116, 124, 145, 204, 226 |
| abstract_inverted_index.is | 3, 50, 192 |
| abstract_inverted_index.it | 89 |
| abstract_inverted_index.of | 16, 18, 39, 56, 64, 74, 78, 87, 94, 103, 110, 132, 137, 163, 189, 254 |
| abstract_inverted_index.on | 194 |
| abstract_inverted_index.to | 21, 32, 36, 91, 156, 165 |
| abstract_inverted_index.OA. | 40, 107, 259 |
| abstract_inverted_index.The | 41, 186 |
| abstract_inverted_index.UPR | 239 |
| abstract_inverted_index.and | 8, 24, 62, 70, 83, 120, 141, 161, 175, 196, 210, 218, 223, 237, 240 |
| abstract_inverted_index.but | 80 |
| abstract_inverted_index.due | 20 |
| abstract_inverted_index.for | 251 |
| abstract_inverted_index.has | 29 |
| abstract_inverted_index.how | 88 |
| abstract_inverted_index.its | 22, 81, 159 |
| abstract_inverted_index.may | 245 |
| abstract_inverted_index.new | 232 |
| abstract_inverted_index.the | 14, 37, 54, 60, 72, 75, 84, 92, 101, 138, 238, 252 |
| abstract_inverted_index.(OA) | 2 |
| abstract_inverted_index.ERN1 | 105, 111, 134, 191, 199, 244 |
| abstract_inverted_index.PGRN | 195, 208 |
| abstract_inverted_index.This | 98, 229 |
| abstract_inverted_index.been | 30 |
| abstract_inverted_index.into | 234 |
| abstract_inverted_index.life | 17 |
| abstract_inverted_index.role | 102 |
| abstract_inverted_index.that | 11, 242 |
| abstract_inverted_index.type | 182 |
| abstract_inverted_index.Local | 130 |
| abstract_inverted_index.XBP1s | 168, 197, 211 |
| abstract_inverted_index.XBP1u | 164 |
| abstract_inverted_index.binds | 155 |
| abstract_inverted_index.joint | 255 |
| abstract_inverted_index.serve | 246 |
| abstract_inverted_index.study | 99, 230 |
| abstract_inverted_index.which | 49 |
| abstract_inverted_index.XBP1s. | 167 |
| abstract_inverted_index.during | 67 |
| abstract_inverted_index.effect | 188 |
| abstract_inverted_index.enzyme | 43 |
| abstract_inverted_index.highly | 51 |
| abstract_inverted_index.matrix | 140 |
| abstract_inverted_index.model. | 129, 148 |
| abstract_inverted_index.remain | 96 |
| abstract_inverted_index.stress | 28, 69 |
| abstract_inverted_index.target | 250 |
| abstract_inverted_index.(PGRN), | 151 |
| abstract_inverted_index.IRE1α, | 157 |
| abstract_inverted_index.IRE1α/ | 104, 190, 243 |
| abstract_inverted_index.OA-like | 117 |
| abstract_inverted_index.affects | 13 |
| abstract_inverted_index.closely | 34 |
| abstract_inverted_index.disease | 10 |
| abstract_inverted_index.further | 176 |
| abstract_inverted_index.induced | 127 |
| abstract_inverted_index.quality | 15 |
| abstract_inverted_index.related | 35 |
| abstract_inverted_index.spliced | 46 |
| abstract_inverted_index.through | 172 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Specific | 108 |
| abstract_inverted_index.abnormal | 65 |
| abstract_inverted_index.collagen | 178, 184, 215, 220, 227 |
| abstract_inverted_index.delivery | 131 |
| abstract_inverted_index.function | 82 |
| abstract_inverted_index.generate | 166 |
| abstract_inverted_index.insights | 233 |
| abstract_inverted_index.pathway, | 48 |
| abstract_inverted_index.patients | 19 |
| abstract_inverted_index.promotes | 59 |
| abstract_inverted_index.protects | 169 |
| abstract_inverted_index.proteins | 66 |
| abstract_inverted_index.provides | 231 |
| abstract_inverted_index.reducing | 207 |
| abstract_inverted_index.relieved | 135 |
| abstract_inverted_index.reported | 31 |
| abstract_inverted_index.resulted | 115 |
| abstract_inverted_index.splicing | 162 |
| abstract_inverted_index.suggests | 241 |
| abstract_inverted_index.unclear. | 97 |
| abstract_inverted_index.arthritis | 128 |
| abstract_inverted_index.articular | 170 |
| abstract_inverted_index.cartilage | 118, 139, 171, 202 |
| abstract_inverted_index.dependent | 193 |
| abstract_inverted_index.disabling | 23 |
| abstract_inverted_index.diseases, | 257 |
| abstract_inverted_index.expressed | 52 |
| abstract_inverted_index.imbalance | 225 |
| abstract_inverted_index.including | 258 |
| abstract_inverted_index.maintains | 71, 177 |
| abstract_inverted_index.patients, | 58 |
| abstract_inverted_index.potential | 249 |
| abstract_inverted_index.prevented | 142 |
| abstract_inverted_index.promoting | 158 |
| abstract_inverted_index.protein-1 | 45 |
| abstract_inverted_index.refolding | 63 |
| abstract_inverted_index.seriously | 12 |
| abstract_inverted_index.signaling | 174 |
| abstract_inverted_index.splicing, | 212 |
| abstract_inverted_index.splicing. | 198 |
| abstract_inverted_index.stability | 73 |
| abstract_inverted_index.treatment | 253 |
| abstract_inverted_index.chaperone, | 154 |
| abstract_inverted_index.decreasing | 214 |
| abstract_inverted_index.deficiency | 109, 200 |
| abstract_inverted_index.expression | 209, 217 |
| abstract_inverted_index.mechanisms | 86 |
| abstract_inverted_index.regulating | 181 |
| abstract_inverted_index.structural | 221 |
| abstract_inverted_index.surgically | 126 |
| abstract_inverted_index.triggering | 219 |
| abstract_inverted_index.underlying | 85 |
| abstract_inverted_index.accelerated | 121, 201 |
| abstract_inverted_index.contributes | 90 |
| abstract_inverted_index.degradation | 61, 136 |
| abstract_inverted_index.destruction | 119 |
| abstract_inverted_index.development | 144 |
| abstract_inverted_index.environment | 77 |
| abstract_inverted_index.expression. | 185 |
| abstract_inverted_index.full-joint, | 5 |
| abstract_inverted_index.homeostasis | 179 |
| abstract_inverted_index.progranulin | 150 |
| abstract_inverted_index.progression | 38, 93, 123 |
| abstract_inverted_index.properties. | 26 |
| abstract_inverted_index.chondrocytes | 55, 113 |
| abstract_inverted_index.degeneration | 203 |
| abstract_inverted_index.degenerative | 7, 256 |
| abstract_inverted_index.homeostasis. | 228 |
| abstract_inverted_index.inflammatory | 9 |
| abstract_inverted_index.investigates | 100 |
| abstract_inverted_index.pain-causing | 25 |
| abstract_inverted_index.pathogenesis | 236 |
| abstract_inverted_index.subsequently | 213 |
| abstract_inverted_index.ACLT-mediated | 147 |
| abstract_inverted_index.TNF-α/ERK1/2 | 173 |
| abstract_inverted_index.abnormalities | 222 |
| abstract_inverted_index.chondrocytes, | 79 |
| abstract_inverted_index.intracellular | 153 |
| abstract_inverted_index.spontaneously | 114 |
| abstract_inverted_index.(IRE1α/XBP1s) | 47 |
| abstract_inverted_index.Osteoarthritis | 1 |
| abstract_inverted_index.multifactorial, | 6 |
| abstract_inverted_index.phosphorylation | 160 |
| abstract_inverted_index.Mechanistically, | 149 |
| abstract_inverted_index.1α/X-box-binding | 44 |
| abstract_inverted_index.chondroprotective | 187 |
| abstract_inverted_index.inositol-requiring | 42 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 96 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 18 |
| citation_normalized_percentile.value | 0.9024068 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |