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IRMA: Machine learning-based harmonization of 18F-FDG PET brain scans in multi-center studies
January 2025 • Sofie Lövdal, Rick van Veen, Giulia Carli, Remco J. Renken, Tamara Shiner, Noa Bregman, Rotem Orad, Dario Arnaldi, Beatrice Orso, Silvia Morbelli, Pi…
<title>Abstract</title> Purpose: Center-specific effects in PET brain scans arise due to differences in technical and procedural aspects. This restricts the merging of data between centers and introduces source-specific bias. Methods: We demonstrate the use of the recently proposed machine learning method Iterated Relevance Matrix Analysis (IRMA) for harmonization of center-specific effects in brain <sup>18</sup>F-Fluorodeoxyglucose (<sup>18</sup>F-FDG) PET scans. The center difference is learned by applying IRMA …