Iron Regulatory Mechanisms in Saccharomyces cerevisiae Article Swipe
Lucía Ramos-Alonso
,
Antonia María Romero
,
María Teresa Martínez‐Pastor
,
Sergi Puig
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2020.582830
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2020.582830
Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox cofactor in many cellular processes. However, excess iron can damage cells since it promotes the generation of reactive oxygen species. The budding yeast Saccharomyces cerevisiae has been used as a model organism to study the adaptation of eukaryotic cells to changes in iron availability. Upon iron deficiency, yeast utilizes two transcription factors, Aft1 and Aft2, to activate the expression of a set of genes known as the iron regulon, which are implicated in iron uptake, recycling and mobilization. Moreover, Aft1 and Aft2 activate the expression of Cth2, an mRNA-binding protein that limits the expression of genes encoding for iron-containing proteins or that participate in iron-using processes. Cth2 contributes to prioritize iron utilization in particular pathways over other highly iron-consuming and non-essential processes including mitochondrial respiration. Recent studies have revealed that iron deficiency also alters many other metabolic routes including amino acid and lipid synthesis, the mitochondrial retrograde response, transcription, translation and deoxyribonucleotide synthesis; and activates the DNA damage and general stress responses. At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity. The complete sequencing and annotation of many yeast genomes is starting to unveil the diversity and evolution of the iron homeostasis network in this species.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmicb.2020.582830
- https://www.frontiersin.org/articles/10.3389/fmicb.2020.582830/pdf
- OA Status
- gold
- Cited By
- 92
- References
- 77
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3084241396
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3084241396Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmicb.2020.582830Digital Object Identifier
- Title
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Iron Regulatory Mechanisms in Saccharomyces cerevisiaeWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-09-09Full publication date if available
- Authors
-
Lucía Ramos-Alonso, Antonia María Romero, María Teresa Martínez‐Pastor, Sergi PuigList of authors in order
- Landing page
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https://doi.org/10.3389/fmicb.2020.582830Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fmicb.2020.582830/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fmicb.2020.582830/pdfDirect OA link when available
- Concepts
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Saccharomyces cerevisiae, Regulon, Biology, Transcription factor, Biochemistry, Cell biology, Iron–sulfur cluster, Yeast, Vacuole, Gene, Cytoplasm, EnzymeTop concepts (fields/topics) attached by OpenAlex
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92Total citation count in OpenAlex
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2025: 22, 2024: 24, 2023: 17, 2022: 16, 2021: 10Per-year citation counts (last 5 years)
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77Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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