Abstract Background Alterations in EEG traces are observed in synaptic failure with a reduction in the background α rhythm and an increase in slow frequencies (θ‐δ). The aim of the study is to evaluate whether quantitative EEG (QEEG) can be a reliable biomarker of neuro‐cognitive disorders (NCD), able to identify patients with mild and major‐NCD, and to reflect the clinical course over time. Method 63 donors from the Abbiategrasso Brain Bank were included in the study. According to our protocol, the subjects were …