Is the Sars-CoV-2 virus a possible trigger agent for the development of achalasia? Article Swipe
Janette Furuzawa‐Carballeda
,
M.E. Icaza-Chávez
,
Diana Aguilar‐León
,
Norma Uribe‐Uribe
,
María del Carmen Núñez-Pompa
,
Alonso Trigos‐Díaz
,
Rodrigo Areán‐Sanz
,
Dheni A. Fernández‐Camargo
,
Enrique Coss‐Adame
,
Miguel A. Valdovinos
,
Eduardo Briceño‐Souza
,
Luis Alberto Chi‐Cervera
,
Miriam Olivares‐Flores
,
Gonzalo Torres‐Villalobos
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.09.19.22280068
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.09.19.22280068
BACKGROUND Previous studies have suggested that achalasia is an autoimmune disease whose probable causal agent is a neurotropic virus that chronically infects the myenteric plexus of the esophagus and, in a genetically susceptible host, induces the disease. The association between achalasia and coronaviruses has not been reported in the literature. AIMS To evaluate the presence of the SARS-CoV-2 virus, the ACE2 expression, the tissue architecture, and immune response in the lower esophageal sphincter muscle (LESm) of achalasia patients who had SARS-CoV-2 (achalasia-COVID-19) infection before laparoscopic Heller myotomy (LHM) and compare the findings with type II achalasia patients and transplant donors (controls) without COVID-19. METHODS The LESm of 7 achalasia-COVID-19 patients (diagnosed by PCR), ten achalasia patients, and ten controls without COVID-19 were included. The presence of the virus was evaluated by in situ PCR and immunohistochemistry. ACE2 receptor expression and effector CD4 T cell and regulatory subsets were determined by immunohistochemistry. RESULTS Coronavirus was detected in 6/7 patients-COVID-19. The SARS-CoV-2 was undetectable in the LESm of the achalasia patients and controls. The ACE2 receptor was expressed in all the patients and controls. One patient developed achalasia type II post-COVID-19. The percentage of Th22/Th17/Th1/pDCreg was higher in achalasia and achalasia-COVID-19 pre-HLM vs. controls. The Th2/Treg/Breg cell percentages were higher only in achalasia vs. controls. CONCLUSION The presence of the SARS-CoV2 and its receptor in the LESm of type II achalasia-COVID-19 patients but not in the controls suggests that it could affect the myenteric plexus. Unlike achalasia, patients-COVID-19 have an imbalance between effector CD4 T cells and the regulatory mechanisms.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.09.19.22280068
- https://www.medrxiv.org/content/medrxiv/early/2022/09/20/2022.09.19.22280068.full.pdf
- OA Status
- green
- Cited By
- 4
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4296910985
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4296910985Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2022.09.19.22280068Digital Object Identifier
- Title
-
Is the Sars-CoV-2 virus a possible trigger agent for the development of achalasia?Work title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-09-20Full publication date if available
- Authors
-
Janette Furuzawa‐Carballeda, M.E. Icaza-Chávez, Diana Aguilar‐León, Norma Uribe‐Uribe, María del Carmen Núñez-Pompa, Alonso Trigos‐Díaz, Rodrigo Areán‐Sanz, Dheni A. Fernández‐Camargo, Enrique Coss‐Adame, Miguel A. Valdovinos, Eduardo Briceño‐Souza, Luis Alberto Chi‐Cervera, Miriam Olivares‐Flores, Gonzalo Torres‐VillalobosList of authors in order
- Landing page
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https://doi.org/10.1101/2022.09.19.22280068Publisher landing page
- PDF URL
-
https://www.medrxiv.org/content/medrxiv/early/2022/09/20/2022.09.19.22280068.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.medrxiv.org/content/medrxiv/early/2022/09/20/2022.09.19.22280068.full.pdfDirect OA link when available
- Concepts
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Achalasia, Esophagus, Gastroenterology, Medicine, Virus, Myenteric plexus, Internal medicine, Immunohistochemistry, ImmunologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2023: 2, 2022: 1Per-year citation counts (last 5 years)
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24Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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