Is there a relationship between objectively measured cognitive changes in patients with solid tumours undergoing chemotherapy treatment and their health‐related quality of life outcomes? A systematic review Article Swipe
Miriam Dwek
,
Lorna Rixon
,
Catherine S. Hurt
,
Alice Simon
,
Stanton Newman
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1002/pon.4331
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1002/pon.4331
Background This systematic review examines whether there is a relationship between objective measures of chemotherapy‐related cognitive impairment in patients with solid cancer tumours and health‐related quality of life (HRQoL). Methods Multiple online databases were searched (including Ovid MEDLINE, EMBASE, PsycINFO, PsycARTICLES, CINAHL, PubMed, and Web of Science) to identify articles published between 1980 and 2016 examining the extent of chemotherapy‐related cognitive deficit and its relationship with HRQoL in cancer patients . Of 2769 potentially relevant articles, 17 studies met the inclusion criteria for the current review. Results Evidence for the presence of cognitive impairment in patients treated with chemotherapy was found in 15 of the 17 studies. Of the 15 studies finding some sort of cognitive impairment, 12 were in female breast cancer patients, 2 in bowel cancer, and 1 each in ovarian and lung cancer. Three of the 15 studies found a significant relationship between various objectively measured cognitively impaired domains and specific HRQoL outcomes. There was, however, only limited testing of the relationships between quantifiable cognitive dysfunction and HRQoL domains. Conclusions This review suggests that in patients with solid tumours, where there is a relationship between chemotherapy treatment and cognitive impairment, the type and level of cognitive decline does not consistently appear to affect such patients' HRQoL. This could be partly explained by variations in study design, measures used, definitions of cognitive impairment, varying measurement time frames, small sample sizes, and differences in disease severity and type of treatment regimes.
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Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1002/pon.4331
- OA Status
- green
- Cited By
- 22
- References
- 65
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2558672681
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2558672681Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/pon.4331Digital Object Identifier
- Title
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Is there a relationship between objectively measured cognitive changes in patients with solid tumours undergoing chemotherapy treatment and their health‐related quality of life outcomes? A systematic reviewWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2016Year of publication
- Publication date
-
2016-11-28Full publication date if available
- Authors
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Miriam Dwek, Lorna Rixon, Catherine S. Hurt, Alice Simon, Stanton NewmanList of authors in order
- Landing page
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https://doi.org/10.1002/pon.4331Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://openaccess.city.ac.uk/id/eprint/16028/3/Systematic%20Review%20-%20Final%20Oct%202016%20%25281%2529.pdfDirect OA link when available
- Concepts
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CINAHL, Medicine, PsycINFO, Cognition, Quality of life (healthcare), MEDLINE, Disease, Cancer, Clinical psychology, Systematic review, Chemotherapy, Internal medicine, Psychiatry, Psychological intervention, Political science, Nursing, LawTop concepts (fields/topics) attached by OpenAlex
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22Total citation count in OpenAlex
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2025: 1, 2024: 3, 2023: 5, 2022: 2, 2021: 2Per-year citation counts (last 5 years)
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65Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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