Saccharomyces cerevisiae as a tool for deciphering Hsp90 molecular chaperone function Article Swipe
Sarah J. Backe
,
Mehdi Mollapour
,
Mark R. Woodford
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1042/ebc20220224
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1042/ebc20220224
Yeast is a valuable model organism for their ease of genetic manipulation, rapid growth rate, and relative similarity to higher eukaryotes. Historically, Saccharomyces cerevisiae has played a major role in discovering the function of complex proteins and pathways that are important for human health and disease. Heat shock protein 90 (Hsp90) is a molecular chaperone responsible for the stabilization and activation of hundreds of integral members of the cellular signaling network. Much important structural and functional work, including many seminal discoveries in Hsp90 biology are the direct result of work carried out in S. cerevisiae. Here, we have provided a brief overview of the S. cerevisiae model system and described how this eukaryotic model organism has been successfully applied to the study of Hsp90 chaperone function.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1042/ebc20220224
- OA Status
- green
- Cited By
- 3
- References
- 165
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4324018009
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4324018009Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1042/ebc20220224Digital Object Identifier
- Title
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Saccharomyces cerevisiae as a tool for deciphering Hsp90 molecular chaperone functionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-03-13Full publication date if available
- Authors
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Sarah J. Backe, Mehdi Mollapour, Mark R. WoodfordList of authors in order
- Landing page
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https://doi.org/10.1042/ebc20220224Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://pmc.ncbi.nlm.nih.gov/articles/PMC10497724/pdf/nihms-1884185.pdfDirect OA link when available
- Concepts
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Saccharomyces cerevisiae, Hsp90, Chaperone (clinical), Model organism, Yeast, Heat shock protein, Biology, Computational biology, Organism, Budding yeast, Function (biology), Cell biology, Genetics, Gene, Pathology, MedicineTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2025: 2, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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165Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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