Isavuconazole Exposure in Critically Ill Patients Treated with Extracorporeal Membrane Oxygenation: Two Case Reports and a Narrative Literature Review Article Swipe
Beatrijs Mertens
,
Omar Elkayal
,
Erwin Dreesen
,
Joost Wauters
,
Philippe Meersseman
,
Yves Debaveye
,
Karlien Degezelle
,
Pieter Vermeersch
,
Matthias Gijsen
,
Isabel Spriet
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/antibiotics12071085
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/antibiotics12071085
Effective dosing of isavuconazole in patients supported by extracorporeal membrane oxygenation (ECMO) is important due to the role of isavuconazole as a first-line treatment in patients with influenza- and COVID-19-associated pulmonary aspergillosis. To date, robust pharmacokinetic data in patients supported by ECMO are limited. Therefore, it is unknown whether ECMO independently impacts isavuconazole exposure. We measured isavuconazole plasma concentrations in two patients supported by ECMO and estimated individual pharmacokinetic parameters using non-compartmental analysis and two previously published population pharmacokinetic models. Furthermore, a narrative literature review on isavuconazole exposure in adult patients receiving ECMO was performed. The 24 h areas under the concentration–time curve and trough concentrations of isavuconazole were lower in both patients compared with exposure values published before. In the literature, highly variable isavuconazole concentrations have been documented in patients with ECMO support. The independent effect of ECMO versus critical illness itself on isavuconazole exposure cannot be deduced from our and previously published (case) reports. Pending additional data, therapeutic drug monitoring is recommended in critically ill patients, regardless of ECMO support.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antibiotics12071085
- https://www.mdpi.com/2079-6382/12/7/1085/pdf?version=1687850753
- OA Status
- gold
- Cited By
- 12
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4381616883
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4381616883Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/antibiotics12071085Digital Object Identifier
- Title
-
Isavuconazole Exposure in Critically Ill Patients Treated with Extracorporeal Membrane Oxygenation: Two Case Reports and a Narrative Literature ReviewWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-06-21Full publication date if available
- Authors
-
Beatrijs Mertens, Omar Elkayal, Erwin Dreesen, Joost Wauters, Philippe Meersseman, Yves Debaveye, Karlien Degezelle, Pieter Vermeersch, Matthias Gijsen, Isabel SprietList of authors in order
- Landing page
-
https://doi.org/10.3390/antibiotics12071085Publisher landing page
- PDF URL
-
https://www.mdpi.com/2079-6382/12/7/1085/pdf?version=1687850753Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2079-6382/12/7/1085/pdf?version=1687850753Direct OA link when available
- Concepts
-
Extracorporeal membrane oxygenation, Medicine, Critically ill, Pharmacokinetics, Dosing, Population, Intensive care medicine, Therapeutic drug monitoring, Coronavirus disease 2019 (COVID-19), Extracorporeal, Internal medicine, Disease, Infectious disease (medical specialty), Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 6Per-year citation counts (last 5 years)
- References (count)
-
38Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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