ISONIAZID (INH) Article Swipe
Umer Aleem
,
Rahman Shah
,
Noor M. Khan
,
Muhammad Asad Suliman
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.29309/tpmj/18.4635
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.29309/tpmj/18.4635
Objectives: Hepatotoxicity is the most complicated side effect of isoniazid (inh)in the patient treated for tuberculosis. In causes 8–30% hepatotoxicity in the developing world.Metabolism of INH produces a metabolite, called acetyl isoniazid. In this study hepatoprotectiveeffect of honey, in isoniazid induced animal model was assessed. Study Design: Randomizedcontrol trial. Setting: Saidu Medical College, Saidu Sharif Swat, KP. Period: October ToDecember 2017. Material and Methods: 40 healthy male rabbits were assigned randomly tothe group i, ii, iii and iv by using lottery method. Ten animals were grouped each row. Theisoniazid-induced hepatotoxic model was created by giving 50 mg inh/kg orally on daily basisfor eleven days. Group i was taken as negative control group ii as a positive control. Group iii andiv were experimental groups treated with 50 mg /kg/day and 100 mg /kg/day buckwheat honeyrespectively for eleven days. SPSS Version 16 software was used, mean, s.d. were determinedin all the groups. Values of serum bilirubin, sgpt, and alkaline phosphatase were comparedwith each other using pairt-test. Results: SGPT, Serum bilirubin, and alkaline phosphatasewere obtained in all the animals. Comparing group 1 negative control with group 2, 3 and 4shows statistical significance, (p=0.00). Comparing group 2 positive control with 3 and 4 showsstatistical significance, (p=0.00). Further comparing group 3 with group 4 also shows statisticalsignificance (p=0.00). Conclusion: From the above finding, it has been revealed that honeyhas got a protective effect in regressing hepatitis that has been induced in rabbit’s model byhigh doses of isoniazid. Related studies performed in which different chemicals and drugs havebeen tried for their protective role in isoniazid induced hepatitis also shows a similar type ofresults.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.29309/tpmj/18.4635
- http://www.theprofesional.com/index.php/tpmj/article/download/210/140
- OA Status
- diamond
- Cited By
- 1
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4230317802
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4230317802Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.29309/tpmj/18.4635Digital Object Identifier
- Title
-
ISONIAZID (INH)Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-10-10Full publication date if available
- Authors
-
Umer Aleem, Rahman Shah, Noor M. Khan, Muhammad Asad SulimanList of authors in order
- Landing page
-
https://doi.org/10.29309/tpmj/18.4635Publisher landing page
- PDF URL
-
https://www.theprofesional.com/index.php/tpmj/article/download/210/140Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.theprofesional.com/index.php/tpmj/article/download/210/140Direct OA link when available
- Concepts
-
Isoniazid, Medicine, Statistical significance, Alkaline phosphatase, Internal medicine, Gastroenterology, Bilirubin, Metabolite, Pharmacology, Tuberculosis, Pathology, Biochemistry, Enzyme, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2022: 1Per-year citation counts (last 5 years)
- References (count)
-
31Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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