Issue Information Article Swipe
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· 2020
· Open Access
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· DOI: https://doi.org/10.1111/tan.13594
· OA: W4230570603
Aims and scope HLA publishes full-length original articles, brief communi cations, commentaries and reviews covering all aspects of genetic control of immunity.The scope includes functional, biochemical, and genetic studies on molecules of the immune system, including cell surface receptors and their ligands, and encompassing cytokines, and chemokines, adhesion and co-stimulating molecules, antigen receptors such as TcR, NKR, CD1, PAMPs, lgs, and genes and products of the major histocompatibility complex including classical and non-classical HLA molecules.Papers should describe ori ginal research carried out in vitro, or in animal models, or involving clinical studies reflecting genetics of immunity in solid organ or bone marrow transplantation, autoimmunity, infectious immunity, allergy, tumor immunity, vaccine science, pregnancy and disease susceptibility.The journal emphasis is on understanding genetic control of immunity through:• Immunogenomics including gene organisation, phylogeny, evolution, regulation, polymorphism particularly where it affects expression and function, population genetics, gene markers (eg.Microsatellite and SNPs) and typing applications or methodology; • Protein or antigen expression and biochemistry of immunologically important molecules including post-translational regulation, cell surface expression, isoforms, serology, tissue expression, cell lineage relationships particularly defined by leucocyte differentiation antigens, cell activation and differentiation markers, myeloid and lymphoid cell surface antigens, platelet antigens, thymic markers and lineageindependent cell surface markers.• Structure and function of molecules that control immune responses including cell surface molecules and their ligands, adhesion molecules, cyto kines, chemokines, antigen receptors such as TcR, immunoglobulins, NKR, Toll-like receptors, HLA, CD1, MICA/B, PAMPs, Complement and other immune effector molecules.Modulation of immune responses by pathogens such as decoy receptors, cytokine analogs and inhibitors of apoptosis or other cellular functions.• Immunogenetic tools including new genes, sequences, mAbs, poly morphism databases particularly HLA alleles, population data, HLA-peptide repertoires in health and disease, definition of minor histocompatibility antigens, allelic variants, gene maps and bioinformatics.
