Staphylococcus aureus LukMF′ targets neutrophils to promote skin and soft tissue infection Article Swipe
Daiane Boff
,
R Chandrasekaran
,
Gregory Putzel
,
Rachel M. Kratofil
,
Xuhui Zheng
,
Ashley Castellaw
,
Kody Mansfield
,
Ikjot Sidhu
,
Avantika Dhabaria
,
Keenan A. Lacey
,
Sandra González
,
Filadelfia Tadjibaeva
,
Beatrix Ueberheide
,
Cynthia A. Loomis
,
Alejandro Pironti
,
Silva Holtfreter
,
Shruti Naik
,
Victor J. Torres
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1126/sciadv.adr5240
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1126/sciadv.adr5240
Pathogens have evolved to be highly adapted to their natural host. Community-associated methicillin-resistant Staphylococcus aureus USA300, for instance, is a lineage responsible for the epidemic of skin and soft tissue infections (SSTIs) in humans. Owing to its human tropism, mechanisms that enabled the rise of USA300 as a major skin pathogen remain incompletely defined. By leveraging a rodent-adapted strain of S. aureus , we developed a natural model of SSTIs. We found that LukMF′, a pore-forming leukocidin homolog to the human-specific LukSF-PV toxin, drives skin pathology in mice. LukMF′ lyses neutrophils via the chemokine receptor CCR1, which in turn fuels inflammatory pathology and microbial survival within the infectious nidus. Ablation of CCR1, depletion of neutrophils, or vaccination with LukMF′ all protected mice from skin pathology. Thus, these data support epidemiological studies linking leukocidins with human SSTIs and highlight the power of natural models to unearth potential targets to curtail infections.
Related Topics
Concepts
Leukocidin
Staphylococcus aureus
Microbiology
Staphylococcal Skin Infections
Chemokine
Human pathogen
Biology
Skin infection
Tropism
Panton–Valentine leukocidin
Immunology
Human skin
Tissue tropism
CCR1
Chemokine receptor
Methicillin-resistant Staphylococcus aureus
Immune system
Bacteria
Virus
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1126/sciadv.adr5240
- OA Status
- gold
- Cited By
- 2
- References
- 85
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412021690
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4412021690Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1126/sciadv.adr5240Digital Object Identifier
- Title
-
Staphylococcus aureus LukMF′ targets neutrophils to promote skin and soft tissue infectionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-07-04Full publication date if available
- Authors
-
Daiane Boff, R Chandrasekaran, Gregory Putzel, Rachel M. Kratofil, Xuhui Zheng, Ashley Castellaw, Kody Mansfield, Ikjot Sidhu, Avantika Dhabaria, Keenan A. Lacey, Sandra González, Filadelfia Tadjibaeva, Beatrix Ueberheide, Cynthia A. Loomis, Alejandro Pironti, Silva Holtfreter, Shruti Naik, Victor J. TorresList of authors in order
- Landing page
-
https://doi.org/10.1126/sciadv.adr5240Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1126/sciadv.adr5240Direct OA link when available
- Concepts
-
Leukocidin, Staphylococcus aureus, Microbiology, Staphylococcal Skin Infections, Chemokine, Human pathogen, Biology, Skin infection, Tropism, Panton–Valentine leukocidin, Immunology, Human skin, Tissue tropism, CCR1, Chemokine receptor, Methicillin-resistant Staphylococcus aureus, Immune system, Bacteria, Virus, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
85Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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