TTN and BAG3 in Cancer Therapy–Related Cardiomyopathy Among Long-Term Survivors of Childhood Cancer Article Swipe
Achal Neupane
,
Kateryna Petrykey
,
Kendrick Li
,
Jennifer C. French
,
Xin Zhou
,
Jian Wang
,
Cindy Im
,
Stephanie B. Dixon
,
Matthew J. Ehrhardt
,
Daniel A. Mulrooney
,
John L. Jefferies
,
M. Monica Gramatges
,
Eric J. Chow
,
Smita Bhatia
,
Leslie L. Robison
,
Kirsten K. Ness
,
Melissa M. Hudson
,
Paul W. Burridge
,
Gregory T. Armstrong
,
Yutaka Yasui
,
Yadav Sapkota
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1001/jamanetworkopen.2025.15793
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1001/jamanetworkopen.2025.15793
Importance Cancer therapy–related cardiomyopathy (CCM) is an important concern for childhood cancer survivors. In the general population, rare variants in TTN and BAG3 are associated with an increased risk of familial dilated cardiomyopathy, and common variants are associated with a decreased risk of sporadic dilated cardiomyopathy. Objectives To examine associations of common and rare protein-altering variants (PAVs) in TTN and BAG3 with late-onset CCM risk in childhood cancer survivors. Design, Setting, and Participants This retrospective cohort study with a prospective follow-up included childhood cancer survivors from the St Jude Lifetime Cohort (SJLIFE) and the Childhood Cancer Survivor Study (CCSS) with prior exposure to anthracyclines and/or chest-directed radiation. Cancer therapy–related cardiomyopathy was clinically assessed in SJLIFE and self-reported in CCSS, with severity graded using Common Terminology Criteria for Adverse Events, version 4.03. The data analysis was conducted from January 4, 2023, to March 6, 2025. Exposure Late-onset CCM. Main Outcome and Measures Multivariable logistic regression was used to evaluate the association of common variants in TTN and BAG3 with late-onset CCM risk, adjusting for relevant demographic and cancer treatment exposures. In SJLIFE alone, 7 echocardiographic parameters were assessed. Rare PAVs were examined using Fisher exact test. Cohort-specific results were combined using meta-analytic approaches. Results The cohort included 1843 childhood cancer survivors from SJLIFE (median [IQR] age at CCM diagnosis, 34.9 [28.0-42.3] years; 53.2% male) and 4577 from CCSS (median [IQR] age at CCM diagnosis, 32.0 [23.0-41.0] years; 51.6% female). In the combined sample of European ancestry survivors from SJLIFE (205 with CCM grade ≥2) and CCSS (248 with CCM grade ≥2), common variants rs3829746-C in TTN (odds ratio, 0.81; 95% CI, 0.68-0.97) and rs2234962-C in BAG3 (odds ratio, 0.79; 95% CI, 0.65-0.95) were associated with a decreased risk of late-onset CCM. In SJLIFE African ancestry survivors, no association was observed with either of the common variants. Rare PAVs were not associated with late-onset CCM in European or African ancestry survivors. In European ancestry survivors, both rs3829746-C and rs2234962-C were also associated with reduced left ventricular end-systolic volume (β [SE], −1.90 [0.65] and −2.68 [0.64], respectively) and global longitudinal peak strain (β [SE], −0.31 [0.13] and −0.30 [0.12]) and with increased left ventricular ejection fraction (β [SE], 0.62 [0.27] and 0.86 [0.27], respectively). Conclusions and Relevance The findings of this cohort study show that common variants in TTN and BAG3 are associated with a decreased risk of late-onset CCM among childhood cancer survivors, while rare PAVs showed no association.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1001/jamanetworkopen.2025.15793
- OA Status
- gold
- Cited By
- 1
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411489549
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4411489549Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1001/jamanetworkopen.2025.15793Digital Object Identifier
- Title
-
TTN and BAG3 in Cancer Therapy–Related Cardiomyopathy Among Long-Term Survivors of Childhood CancerWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-06-20Full publication date if available
- Authors
-
Achal Neupane, Kateryna Petrykey, Kendrick Li, Jennifer C. French, Xin Zhou, Jian Wang, Cindy Im, Stephanie B. Dixon, Matthew J. Ehrhardt, Daniel A. Mulrooney, John L. Jefferies, M. Monica Gramatges, Eric J. Chow, Smita Bhatia, Leslie L. Robison, Kirsten K. Ness, Melissa M. Hudson, Paul W. Burridge, Gregory T. Armstrong, Yutaka Yasui, Yadav SapkotaList of authors in order
- Landing page
-
https://doi.org/10.1001/jamanetworkopen.2025.15793Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1001/jamanetworkopen.2025.15793Direct OA link when available
- Concepts
-
Medicine, Common Terminology Criteria for Adverse Events, Internal medicine, Cohort, Cancer, Cardiomyopathy, Population, Retrospective cohort study, Oncology, Pediatrics, Heart failure, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
35Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4411489549 |
|---|---|
| doi | https://doi.org/10.1001/jamanetworkopen.2025.15793 |
| ids.doi | https://doi.org/10.1001/jamanetworkopen.2025.15793 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40540274 |
| ids.openalex | https://openalex.org/W4411489549 |
| fwci | 4.42873758 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D008297 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Male |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D005260 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Female |
| mesh[3].qualifier_ui | Q000706 |
| mesh[3].descriptor_ui | D000073116 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | statistics & numerical data |
| mesh[3].descriptor_name | Cancer Survivors |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D048868 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | Adaptor Proteins, Signal Transducing |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D012189 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Retrospective Studies |
| mesh[6].qualifier_ui | Q000235 |
| mesh[6].descriptor_ui | D051017 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | genetics |
| mesh[6].descriptor_name | Apoptosis Regulatory Proteins |
| mesh[7].qualifier_ui | Q000235 |
| mesh[7].descriptor_ui | D009202 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | genetics |
| mesh[7].descriptor_name | Cardiomyopathies |
| mesh[8].qualifier_ui | Q000209 |
| mesh[8].descriptor_ui | D009202 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | etiology |
| mesh[8].descriptor_name | Cardiomyopathies |
| mesh[9].qualifier_ui | Q000453 |
| mesh[9].descriptor_ui | D009202 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | epidemiology |
| mesh[9].descriptor_name | Cardiomyopathies |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D000328 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Adult |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D002648 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Child |
| mesh[12].qualifier_ui | Q000628 |
| mesh[12].descriptor_ui | D009369 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | therapy |
| mesh[12].descriptor_name | Neoplasms |
| mesh[13].qualifier_ui | Q000235 |
| mesh[13].descriptor_ui | D064211 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | genetics |
| mesh[13].descriptor_name | Connectin |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D000293 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Adolescent |
| mesh[15].qualifier_ui | Q000009 |
| mesh[15].descriptor_ui | D018943 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | adverse effects |
| mesh[15].descriptor_name | Anthracyclines |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D011446 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Prospective Studies |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D055815 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Young Adult |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D006801 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Humans |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D008297 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Male |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D005260 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Female |
| mesh[21].qualifier_ui | Q000706 |
| mesh[21].descriptor_ui | D000073116 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | statistics & numerical data |
| mesh[21].descriptor_name | Cancer Survivors |
| mesh[22].qualifier_ui | Q000235 |
| mesh[22].descriptor_ui | D048868 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | genetics |
| mesh[22].descriptor_name | Adaptor Proteins, Signal Transducing |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D012189 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Retrospective Studies |
| mesh[24].qualifier_ui | Q000235 |
| mesh[24].descriptor_ui | D051017 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | genetics |
| mesh[24].descriptor_name | Apoptosis Regulatory Proteins |
| mesh[25].qualifier_ui | Q000235 |
| mesh[25].descriptor_ui | D009202 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | genetics |
| mesh[25].descriptor_name | Cardiomyopathies |
| mesh[26].qualifier_ui | Q000209 |
| mesh[26].descriptor_ui | D009202 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | etiology |
| mesh[26].descriptor_name | Cardiomyopathies |
| mesh[27].qualifier_ui | Q000453 |
| mesh[27].descriptor_ui | D009202 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | epidemiology |
| mesh[27].descriptor_name | Cardiomyopathies |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D000328 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Adult |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D002648 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Child |
| mesh[30].qualifier_ui | Q000628 |
| mesh[30].descriptor_ui | D009369 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | therapy |
| mesh[30].descriptor_name | Neoplasms |
| mesh[31].qualifier_ui | Q000235 |
| mesh[31].descriptor_ui | D064211 |
| mesh[31].is_major_topic | True |
| mesh[31].qualifier_name | genetics |
| mesh[31].descriptor_name | Connectin |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D000293 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Adolescent |
| mesh[33].qualifier_ui | Q000009 |
| mesh[33].descriptor_ui | D018943 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | adverse effects |
| mesh[33].descriptor_name | Anthracyclines |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D011446 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Prospective Studies |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D055815 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Young Adult |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D006801 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Humans |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D008297 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Male |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D005260 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Female |
| mesh[39].qualifier_ui | Q000706 |
| mesh[39].descriptor_ui | D000073116 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | statistics & numerical data |
| mesh[39].descriptor_name | Cancer Survivors |
| mesh[40].qualifier_ui | Q000235 |
| mesh[40].descriptor_ui | D048868 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | genetics |
| mesh[40].descriptor_name | Adaptor Proteins, Signal Transducing |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D012189 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Retrospective Studies |
| mesh[42].qualifier_ui | Q000235 |
| mesh[42].descriptor_ui | D051017 |
| mesh[42].is_major_topic | True |
| mesh[42].qualifier_name | genetics |
| mesh[42].descriptor_name | Apoptosis Regulatory Proteins |
| mesh[43].qualifier_ui | Q000235 |
| mesh[43].descriptor_ui | D009202 |
| mesh[43].is_major_topic | True |
| mesh[43].qualifier_name | genetics |
| mesh[43].descriptor_name | Cardiomyopathies |
| mesh[44].qualifier_ui | Q000209 |
| mesh[44].descriptor_ui | D009202 |
| mesh[44].is_major_topic | True |
| mesh[44].qualifier_name | etiology |
| mesh[44].descriptor_name | Cardiomyopathies |
| mesh[45].qualifier_ui | Q000453 |
| mesh[45].descriptor_ui | D009202 |
| mesh[45].is_major_topic | True |
| mesh[45].qualifier_name | epidemiology |
| mesh[45].descriptor_name | Cardiomyopathies |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D000328 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Adult |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D002648 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Child |
| mesh[48].qualifier_ui | Q000628 |
| mesh[48].descriptor_ui | D009369 |
| mesh[48].is_major_topic | True |
| mesh[48].qualifier_name | therapy |
| mesh[48].descriptor_name | Neoplasms |
| mesh[49].qualifier_ui | Q000235 |
| mesh[49].descriptor_ui | D064211 |
| mesh[49].is_major_topic | True |
| mesh[49].qualifier_name | genetics |
| mesh[49].descriptor_name | Connectin |
| type | article |
| title | TTN and BAG3 in Cancer Therapy–Related Cardiomyopathy Among Long-Term Survivors of Childhood Cancer |
| biblio.issue | 6 |
| biblio.volume | 8 |
| biblio.last_page | e2515793 |
| biblio.first_page | e2515793 |
| topics[0].id | https://openalex.org/T10882 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.995199978351593 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2705 |
| topics[0].subfield.display_name | Cardiology and Cardiovascular Medicine |
| topics[0].display_name | Cardiomyopathy and Myosin Studies |
| topics[1].id | https://openalex.org/T11922 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9853000044822693 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2705 |
| topics[1].subfield.display_name | Cardiology and Cardiovascular Medicine |
| topics[1].display_name | Cardiovascular Effects of Exercise |
| topics[2].id | https://openalex.org/T11677 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9587000012397766 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Congenital heart defects research |
| is_xpac | False |
| apc_list.value | 3000 |
| apc_list.currency | USD |
| apc_list.value_usd | 3000 |
| apc_paid.value | 3000 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 3000 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.9084699749946594 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C2777793932 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6131410598754883 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1116229 |
| concepts[1].display_name | Common Terminology Criteria for Adverse Events |
| concepts[2].id | https://openalex.org/C126322002 |
| concepts[2].level | 1 |
| concepts[2].score | 0.5977748036384583 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[2].display_name | Internal medicine |
| concepts[3].id | https://openalex.org/C72563966 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5914412140846252 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1303415 |
| concepts[3].display_name | Cohort |
| concepts[4].id | https://openalex.org/C121608353 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5729209184646606 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[4].display_name | Cancer |
| concepts[5].id | https://openalex.org/C2778797674 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5616903305053711 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q847583 |
| concepts[5].display_name | Cardiomyopathy |
| concepts[6].id | https://openalex.org/C2908647359 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4436030089855194 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2625603 |
| concepts[6].display_name | Population |
| concepts[7].id | https://openalex.org/C167135981 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4111568331718445 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q2146302 |
| concepts[7].display_name | Retrospective cohort study |
| concepts[8].id | https://openalex.org/C143998085 |
| concepts[8].level | 1 |
| concepts[8].score | 0.36783117055892944 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q162555 |
| concepts[8].display_name | Oncology |
| concepts[9].id | https://openalex.org/C187212893 |
| concepts[9].level | 1 |
| concepts[9].score | 0.3374280333518982 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q123028 |
| concepts[9].display_name | Pediatrics |
| concepts[10].id | https://openalex.org/C2778198053 |
| concepts[10].level | 2 |
| concepts[10].score | 0.1858629286289215 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q181754 |
| concepts[10].display_name | Heart failure |
| concepts[11].id | https://openalex.org/C99454951 |
| concepts[11].level | 1 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q932068 |
| concepts[11].display_name | Environmental health |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.9084699749946594 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/common-terminology-criteria-for-adverse-events |
| keywords[1].score | 0.6131410598754883 |
| keywords[1].display_name | Common Terminology Criteria for Adverse Events |
| keywords[2].id | https://openalex.org/keywords/internal-medicine |
| keywords[2].score | 0.5977748036384583 |
| keywords[2].display_name | Internal medicine |
| keywords[3].id | https://openalex.org/keywords/cohort |
| keywords[3].score | 0.5914412140846252 |
| keywords[3].display_name | Cohort |
| keywords[4].id | https://openalex.org/keywords/cancer |
| keywords[4].score | 0.5729209184646606 |
| keywords[4].display_name | Cancer |
| keywords[5].id | https://openalex.org/keywords/cardiomyopathy |
| keywords[5].score | 0.5616903305053711 |
| keywords[5].display_name | Cardiomyopathy |
| keywords[6].id | https://openalex.org/keywords/population |
| keywords[6].score | 0.4436030089855194 |
| keywords[6].display_name | Population |
| keywords[7].id | https://openalex.org/keywords/retrospective-cohort-study |
| keywords[7].score | 0.4111568331718445 |
| keywords[7].display_name | Retrospective cohort study |
| keywords[8].id | https://openalex.org/keywords/oncology |
| keywords[8].score | 0.36783117055892944 |
| keywords[8].display_name | Oncology |
| keywords[9].id | https://openalex.org/keywords/pediatrics |
| keywords[9].score | 0.3374280333518982 |
| keywords[9].display_name | Pediatrics |
| keywords[10].id | https://openalex.org/keywords/heart-failure |
| keywords[10].score | 0.1858629286289215 |
| keywords[10].display_name | Heart failure |
| language | en |
| locations[0].id | doi:10.1001/jamanetworkopen.2025.15793 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210217848 |
| locations[0].source.issn | 2574-3805 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2574-3805 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | JAMA Network Open |
| locations[0].source.host_organization | https://openalex.org/P4310320259 |
| locations[0].source.host_organization_name | American Medical Association |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320259 |
| locations[0].source.host_organization_lineage_names | American Medical Association |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | JAMA Network Open |
| locations[0].landing_page_url | https://doi.org/10.1001/jamanetworkopen.2025.15793 |
| locations[1].id | pmid:40540274 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | JAMA network open |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40540274 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:12181783 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | JAMA Netw Open |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12181783 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5067358721 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-9041-4383 |
| authorships[0].author.display_name | Achal Neupane |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[0].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[0].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Achal Neupane |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[1].author.id | https://openalex.org/A5043333818 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-5865-3907 |
| authorships[1].author.display_name | Kateryna Petrykey |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[1].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[1].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Kateryna Petrykey |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[2].author.id | https://openalex.org/A5040124903 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Kendrick Li |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[2].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[2].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Kendrick Li |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[3].author.id | https://openalex.org/A5087893700 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-5947-6669 |
| authorships[3].author.display_name | Jennifer C. French |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[3].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[3].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jennifer French |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[4].author.id | https://openalex.org/A5101814981 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-3979-8200 |
| authorships[4].author.display_name | Xin Zhou |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Computational Biology, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[4].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[4].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Xin Zhou |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Computational Biology, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[5].author.id | https://openalex.org/A5100370458 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-5137-0330 |
| authorships[5].author.display_name | Jian Wang |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Computational Biology, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[5].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[5].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Jian Wang |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Computational Biology, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[6].author.id | https://openalex.org/A5085263272 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-0931-9432 |
| authorships[6].author.display_name | Cindy Im |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I130238516 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Pediatrics, University of Minnesota, Minneapolis |
| authorships[6].institutions[0].id | https://openalex.org/I130238516 |
| authorships[6].institutions[0].ror | https://ror.org/017zqws13 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I130238516 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | University of Minnesota |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Cindy Im |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Pediatrics, University of Minnesota, Minneapolis |
| authorships[7].author.id | https://openalex.org/A5078391017 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-3901-3274 |
| authorships[7].author.display_name | Stephanie B. Dixon |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I1313298211 |
| authorships[7].affiliations[1].raw_affiliation_string | Department of Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[7].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[7].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Stephanie B. Dixon |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee, Department of Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[8].author.id | https://openalex.org/A5060175849 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-2781-9983 |
| authorships[8].author.display_name | Matthew J. Ehrhardt |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I1313298211 |
| authorships[8].affiliations[1].raw_affiliation_string | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[8].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[8].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Matthew J. Ehrhardt |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee, Department of Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[9].author.id | https://openalex.org/A5009794067 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-2351-9115 |
| authorships[9].author.display_name | Daniel A. Mulrooney |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I94658018 |
| authorships[9].affiliations[1].raw_affiliation_string | School of Public Health, University of Memphis, Memphis, Tennessee |
| authorships[9].affiliations[2].institution_ids | https://openalex.org/I1313298211 |
| authorships[9].affiliations[2].raw_affiliation_string | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[9].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[9].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[9].institutions[1].id | https://openalex.org/I94658018 |
| authorships[9].institutions[1].ror | https://ror.org/01cq23130 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I94658018 |
| authorships[9].institutions[1].country_code | US |
| authorships[9].institutions[1].display_name | University of Memphis |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Daniel A. Mulrooney |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee, Department of Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee, School of Public Health, University of Memphis, Memphis, Tennessee |
| authorships[10].author.id | https://openalex.org/A5013335511 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-4046-2352 |
| authorships[10].author.display_name | John L. Jefferies |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I94658018 |
| authorships[10].affiliations[0].raw_affiliation_string | School of Public Health, University of Memphis, Memphis, Tennessee |
| authorships[10].institutions[0].id | https://openalex.org/I94658018 |
| authorships[10].institutions[0].ror | https://ror.org/01cq23130 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I94658018 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | University of Memphis |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | John L. Jefferies |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | School of Public Health, University of Memphis, Memphis, Tennessee |
| authorships[11].author.id | https://openalex.org/A5048236963 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-0947-104X |
| authorships[11].author.display_name | M. Monica Gramatges |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I181547552 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Pediatrics, Baylor College of Medicine, Houston, Texas |
| authorships[11].institutions[0].id | https://openalex.org/I181547552 |
| authorships[11].institutions[0].ror | https://ror.org/02pttbw34 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I181547552, https://openalex.org/I2801539370 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | Baylor College of Medicine |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | M. Monica Gramatges |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Pediatrics, Baylor College of Medicine, Houston, Texas |
| authorships[12].author.id | https://openalex.org/A5030772339 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-3349-9330 |
| authorships[12].author.display_name | Eric J. Chow |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I1295499534, https://openalex.org/I201448701, https://openalex.org/I4210089486 |
| authorships[12].affiliations[0].raw_affiliation_string | Fred Hutchinson Cancer Center, Seattle Children’s Hospital, University of Washington, Seattle |
| authorships[12].institutions[0].id | https://openalex.org/I4210089486 |
| authorships[12].institutions[0].ror | https://ror.org/007ps6h72 |
| authorships[12].institutions[0].type | nonprofit |
| authorships[12].institutions[0].lineage | https://openalex.org/I4210089486 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | Fred Hutch Cancer Center |
| authorships[12].institutions[1].id | https://openalex.org/I1295499534 |
| authorships[12].institutions[1].ror | https://ror.org/01njes783 |
| authorships[12].institutions[1].type | healthcare |
| authorships[12].institutions[1].lineage | https://openalex.org/I1295499534 |
| authorships[12].institutions[1].country_code | US |
| authorships[12].institutions[1].display_name | Seattle Children's Hospital |
| authorships[12].institutions[2].id | https://openalex.org/I201448701 |
| authorships[12].institutions[2].ror | https://ror.org/00cvxb145 |
| authorships[12].institutions[2].type | education |
| authorships[12].institutions[2].lineage | https://openalex.org/I201448701 |
| authorships[12].institutions[2].country_code | US |
| authorships[12].institutions[2].display_name | University of Washington |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Eric J. Chow |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Fred Hutchinson Cancer Center, Seattle Children’s Hospital, University of Washington, Seattle |
| authorships[13].author.id | https://openalex.org/A5112575681 |
| authorships[13].author.orcid | |
| authorships[13].author.display_name | Smita Bhatia |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I32389192 |
| authorships[13].affiliations[0].raw_affiliation_string | Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham |
| authorships[13].institutions[0].id | https://openalex.org/I32389192 |
| authorships[13].institutions[0].ror | https://ror.org/008s83205 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I32389192 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | University of Alabama at Birmingham |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Smita Bhatia |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham |
| authorships[14].author.id | https://openalex.org/A5059262359 |
| authorships[14].author.orcid | https://orcid.org/0000-0001-7460-8578 |
| authorships[14].author.display_name | Leslie L. Robison |
| authorships[14].countries | US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[14].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[14].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[14].institutions[0].type | healthcare |
| authorships[14].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[14].institutions[0].country_code | US |
| authorships[14].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Leslie L. Robison |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[15].author.id | https://openalex.org/A5037634832 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-2084-1507 |
| authorships[15].author.display_name | Kirsten K. Ness |
| authorships[15].countries | US |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[15].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[15].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[15].institutions[0].type | healthcare |
| authorships[15].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[15].institutions[0].country_code | US |
| authorships[15].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Kirsten K. Ness |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[16].author.id | https://openalex.org/A5089743648 |
| authorships[16].author.orcid | https://orcid.org/0000-0001-6984-2407 |
| authorships[16].author.display_name | Melissa M. Hudson |
| authorships[16].countries | US |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[16].affiliations[0].raw_affiliation_string | Department of Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[16].affiliations[1].institution_ids | https://openalex.org/I1313298211 |
| authorships[16].affiliations[1].raw_affiliation_string | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[16].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[16].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[16].institutions[0].type | healthcare |
| authorships[16].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[16].institutions[0].country_code | US |
| authorships[16].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Melissa M. Hudson |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee, Department of Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[17].author.id | https://openalex.org/A5091649334 |
| authorships[17].author.orcid | https://orcid.org/0000-0001-9616-0006 |
| authorships[17].author.display_name | Paul W. Burridge |
| authorships[17].countries | US |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I111979921 |
| authorships[17].affiliations[0].raw_affiliation_string | Department of Pharmacology, Northwestern University, Chicago, Illinois |
| authorships[17].institutions[0].id | https://openalex.org/I111979921 |
| authorships[17].institutions[0].ror | https://ror.org/000e0be47 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I111979921 |
| authorships[17].institutions[0].country_code | US |
| authorships[17].institutions[0].display_name | Northwestern University |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Paul W. Burridge |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Department of Pharmacology, Northwestern University, Chicago, Illinois |
| authorships[18].author.id | https://openalex.org/A5065573166 |
| authorships[18].author.orcid | https://orcid.org/0000-0001-8722-4207 |
| authorships[18].author.display_name | Gregory T. Armstrong |
| authorships[18].countries | US |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[18].affiliations[0].raw_affiliation_string | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[18].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[18].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[18].institutions[0].type | healthcare |
| authorships[18].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[18].institutions[0].country_code | US |
| authorships[18].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Gregory T. Armstrong |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[19].author.id | https://openalex.org/A5008672006 |
| authorships[19].author.orcid | https://orcid.org/0000-0002-7717-8638 |
| authorships[19].author.display_name | Yutaka Yasui |
| authorships[19].countries | US |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[19].affiliations[0].raw_affiliation_string | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[19].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[19].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[19].institutions[0].type | healthcare |
| authorships[19].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[19].institutions[0].country_code | US |
| authorships[19].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Yutaka Yasui |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[20].author.id | https://openalex.org/A5036451685 |
| authorships[20].author.orcid | https://orcid.org/0000-0001-5943-9454 |
| authorships[20].author.display_name | Yadav Sapkota |
| authorships[20].countries | US |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[20].affiliations[0].raw_affiliation_string | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| authorships[20].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[20].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[20].institutions[0].type | healthcare |
| authorships[20].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[20].institutions[0].country_code | US |
| authorships[20].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[20].author_position | last |
| authorships[20].raw_author_name | Yadav Sapkota |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, Tennessee |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1001/jamanetworkopen.2025.15793 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-06-21T00:00:00 |
| display_name | TTN and BAG3 in Cancer Therapy–Related Cardiomyopathy Among Long-Term Survivors of Childhood Cancer |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10882 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.995199978351593 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2705 |
| primary_topic.subfield.display_name | Cardiology and Cardiovascular Medicine |
| primary_topic.display_name | Cardiomyopathy and Myosin Studies |
| related_works | https://openalex.org/W2380317881, https://openalex.org/W4361027262, https://openalex.org/W2110043256, https://openalex.org/W2805686800, https://openalex.org/W1978350956, https://openalex.org/W4229488205, https://openalex.org/W3040100953, https://openalex.org/W1527211107, https://openalex.org/W4310147683, https://openalex.org/W2095623428 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1001/jamanetworkopen.2025.15793 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210217848 |
| best_oa_location.source.issn | 2574-3805 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2574-3805 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | JAMA Network Open |
| best_oa_location.source.host_organization | https://openalex.org/P4310320259 |
| best_oa_location.source.host_organization_name | American Medical Association |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320259 |
| best_oa_location.source.host_organization_lineage_names | American Medical Association |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | JAMA Network Open |
| best_oa_location.landing_page_url | https://doi.org/10.1001/jamanetworkopen.2025.15793 |
| primary_location.id | doi:10.1001/jamanetworkopen.2025.15793 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210217848 |
| primary_location.source.issn | 2574-3805 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2574-3805 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | JAMA Network Open |
| primary_location.source.host_organization | https://openalex.org/P4310320259 |
| primary_location.source.host_organization_name | American Medical Association |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320259 |
| primary_location.source.host_organization_lineage_names | American Medical Association |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | JAMA Network Open |
| primary_location.landing_page_url | https://doi.org/10.1001/jamanetworkopen.2025.15793 |
| publication_date | 2025-06-20 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2066617715, https://openalex.org/W2228563143, https://openalex.org/W2938273454, https://openalex.org/W2227148039, https://openalex.org/W2138105710, https://openalex.org/W3112053934, https://openalex.org/W2612291509, https://openalex.org/W3081919089, https://openalex.org/W2761275051, https://openalex.org/W2167989424, https://openalex.org/W2468038249, https://openalex.org/W3039260968, https://openalex.org/W2999230481, https://openalex.org/W2900702841, https://openalex.org/W4382055849, https://openalex.org/W3114059671, https://openalex.org/W2041344443, https://openalex.org/W2567469168, https://openalex.org/W2015758016, https://openalex.org/W2913869848, https://openalex.org/W2162039240, https://openalex.org/W2970754556, https://openalex.org/W2103441770, https://openalex.org/W2168133698, https://openalex.org/W2119180969, https://openalex.org/W3124627257, https://openalex.org/W2618935666, https://openalex.org/W2923926791, https://openalex.org/W2104549677, https://openalex.org/W2133520037, https://openalex.org/W3029661147, https://openalex.org/W2131062132, https://openalex.org/W2908002252, https://openalex.org/W1980991473, https://openalex.org/W4210442455 |
| referenced_works_count | 35 |
| abstract_inverted_index.7 | 182 |
| abstract_inverted_index.a | 39, 78, 284, 391 |
| abstract_inverted_index.4, | 138 |
| abstract_inverted_index.6, | 142 |
| abstract_inverted_index.In | 13, 179, 238, 290, 319 |
| abstract_inverted_index.St | 87 |
| abstract_inverted_index.To | 47 |
| abstract_inverted_index.an | 6, 26 |
| abstract_inverted_index.at | 215, 230 |
| abstract_inverted_index.in | 19, 57, 65, 113, 117, 163, 263, 273, 313, 384 |
| abstract_inverted_index.is | 5 |
| abstract_inverted_index.no | 295, 405 |
| abstract_inverted_index.of | 29, 42, 50, 160, 242, 287, 301, 376, 394 |
| abstract_inverted_index.or | 315 |
| abstract_inverted_index.to | 102, 140, 156 |
| abstract_inverted_index.(β | 336, 349, 363 |
| abstract_inverted_index.95% | 268, 278 |
| abstract_inverted_index.CCM | 63, 169, 216, 231, 250, 257, 312, 396 |
| abstract_inverted_index.CI, | 269, 279 |
| abstract_inverted_index.TTN | 20, 58, 164, 264, 385 |
| abstract_inverted_index.The | 131, 203, 374 |
| abstract_inverted_index.age | 214, 229 |
| abstract_inverted_index.and | 21, 33, 52, 59, 71, 92, 115, 149, 165, 175, 223, 253, 271, 325, 340, 344, 353, 356, 367, 372, 386 |
| abstract_inverted_index.are | 23, 36, 388 |
| abstract_inverted_index.for | 9, 126, 172 |
| abstract_inverted_index.not | 308 |
| abstract_inverted_index.the | 14, 86, 93, 158, 239, 302 |
| abstract_inverted_index.was | 110, 134, 154, 297 |
| abstract_inverted_index.(205 | 248 |
| abstract_inverted_index.(248 | 255 |
| abstract_inverted_index.0.62 | 365 |
| abstract_inverted_index.0.86 | 368 |
| abstract_inverted_index.1843 | 206 |
| abstract_inverted_index.32.0 | 233 |
| abstract_inverted_index.34.9 | 218 |
| abstract_inverted_index.4577 | 224 |
| abstract_inverted_index.BAG3 | 22, 60, 166, 274, 387 |
| abstract_inverted_index.CCM. | 146, 289 |
| abstract_inverted_index.CCSS | 226, 254 |
| abstract_inverted_index.Jude | 88 |
| abstract_inverted_index.Main | 147 |
| abstract_inverted_index.PAVs | 188, 306, 403 |
| abstract_inverted_index.Rare | 187, 305 |
| abstract_inverted_index.This | 73 |
| abstract_inverted_index.also | 328 |
| abstract_inverted_index.both | 323 |
| abstract_inverted_index.data | 132 |
| abstract_inverted_index.from | 85, 136, 210, 225, 246 |
| abstract_inverted_index.left | 332, 359 |
| abstract_inverted_index.peak | 347 |
| abstract_inverted_index.rare | 17, 53, 402 |
| abstract_inverted_index.risk | 28, 41, 64, 286, 393 |
| abstract_inverted_index.show | 380 |
| abstract_inverted_index.that | 381 |
| abstract_inverted_index.this | 377 |
| abstract_inverted_index.used | 155 |
| abstract_inverted_index.were | 185, 189, 197, 281, 307, 327 |
| abstract_inverted_index.with | 25, 38, 61, 77, 99, 119, 167, 249, 256, 283, 299, 310, 330, 357, 390 |
| abstract_inverted_index.(CCM) | 4 |
| abstract_inverted_index.(odds | 265, 275 |
| abstract_inverted_index.0.79; | 277 |
| abstract_inverted_index.0.81; | 267 |
| abstract_inverted_index.2023, | 139 |
| abstract_inverted_index.2025. | 143 |
| abstract_inverted_index.4.03. | 130 |
| abstract_inverted_index.51.6% | 236 |
| abstract_inverted_index.53.2% | 221 |
| abstract_inverted_index.CCSS, | 118 |
| abstract_inverted_index.March | 141 |
| abstract_inverted_index.Study | 97 |
| abstract_inverted_index.[IQR] | 213, 228 |
| abstract_inverted_index.[SE], | 337, 350, 364 |
| abstract_inverted_index.among | 397 |
| abstract_inverted_index.exact | 193 |
| abstract_inverted_index.grade | 251, 258 |
| abstract_inverted_index.male) | 222 |
| abstract_inverted_index.prior | 100 |
| abstract_inverted_index.risk, | 170 |
| abstract_inverted_index.study | 76, 379 |
| abstract_inverted_index.test. | 194 |
| abstract_inverted_index.using | 122, 191, 199 |
| abstract_inverted_index.while | 401 |
| abstract_inverted_index.≥2) | 252 |
| abstract_inverted_index.(CCSS) | 98 |
| abstract_inverted_index.(PAVs) | 56 |
| abstract_inverted_index.Cancer | 1, 95, 107 |
| abstract_inverted_index.Cohort | 90 |
| abstract_inverted_index.Common | 123 |
| abstract_inverted_index.Fisher | 192 |
| abstract_inverted_index.SJLIFE | 114, 180, 211, 247, 291 |
| abstract_inverted_index.[0.13] | 352 |
| abstract_inverted_index.[0.27] | 366 |
| abstract_inverted_index.[0.65] | 339 |
| abstract_inverted_index.alone, | 181 |
| abstract_inverted_index.and/or | 104 |
| abstract_inverted_index.cancer | 11, 67, 83, 176, 208, 399 |
| abstract_inverted_index.cohort | 75, 204, 378 |
| abstract_inverted_index.common | 34, 51, 161, 260, 303, 382 |
| abstract_inverted_index.either | 300 |
| abstract_inverted_index.global | 345 |
| abstract_inverted_index.graded | 121 |
| abstract_inverted_index.ratio, | 266, 276 |
| abstract_inverted_index.sample | 241 |
| abstract_inverted_index.showed | 404 |
| abstract_inverted_index.strain | 348 |
| abstract_inverted_index.volume | 335 |
| abstract_inverted_index.years; | 220, 235 |
| abstract_inverted_index.≥2), | 259 |
| abstract_inverted_index.(median | 212, 227 |
| abstract_inverted_index.Adverse | 127 |
| abstract_inverted_index.African | 292, 316 |
| abstract_inverted_index.Design, | 69 |
| abstract_inverted_index.Events, | 128 |
| abstract_inverted_index.January | 137 |
| abstract_inverted_index.Outcome | 148 |
| abstract_inverted_index.Results | 202 |
| abstract_inverted_index.[0.12]) | 355 |
| abstract_inverted_index.[0.27], | 369 |
| abstract_inverted_index.[0.64], | 342 |
| abstract_inverted_index.concern | 8 |
| abstract_inverted_index.dilated | 31, 44 |
| abstract_inverted_index.examine | 48 |
| abstract_inverted_index.general | 15 |
| abstract_inverted_index.reduced | 331 |
| abstract_inverted_index.results | 196 |
| abstract_inverted_index.version | 129 |
| abstract_inverted_index.−0.30 | 354 |
| abstract_inverted_index.−0.31 | 351 |
| abstract_inverted_index.−1.90 | 338 |
| abstract_inverted_index.−2.68 | 341 |
| abstract_inverted_index.(SJLIFE) | 91 |
| abstract_inverted_index.Criteria | 125 |
| abstract_inverted_index.European | 243, 314, 320 |
| abstract_inverted_index.Exposure | 144 |
| abstract_inverted_index.Lifetime | 89 |
| abstract_inverted_index.Measures | 150 |
| abstract_inverted_index.Setting, | 70 |
| abstract_inverted_index.Survivor | 96 |
| abstract_inverted_index.analysis | 133 |
| abstract_inverted_index.ancestry | 244, 293, 317, 321 |
| abstract_inverted_index.assessed | 112 |
| abstract_inverted_index.combined | 198, 240 |
| abstract_inverted_index.ejection | 361 |
| abstract_inverted_index.evaluate | 157 |
| abstract_inverted_index.examined | 190 |
| abstract_inverted_index.exposure | 101 |
| abstract_inverted_index.familial | 30 |
| abstract_inverted_index.female). | 237 |
| abstract_inverted_index.findings | 375 |
| abstract_inverted_index.fraction | 362 |
| abstract_inverted_index.included | 81, 205 |
| abstract_inverted_index.logistic | 152 |
| abstract_inverted_index.observed | 298 |
| abstract_inverted_index.relevant | 173 |
| abstract_inverted_index.severity | 120 |
| abstract_inverted_index.sporadic | 43 |
| abstract_inverted_index.variants | 18, 35, 55, 162, 261, 383 |
| abstract_inverted_index.Childhood | 94 |
| abstract_inverted_index.Relevance | 373 |
| abstract_inverted_index.adjusting | 171 |
| abstract_inverted_index.assessed. | 186 |
| abstract_inverted_index.childhood | 10, 66, 82, 207, 398 |
| abstract_inverted_index.conducted | 135 |
| abstract_inverted_index.decreased | 40, 285, 392 |
| abstract_inverted_index.follow-up | 80 |
| abstract_inverted_index.important | 7 |
| abstract_inverted_index.increased | 27, 358 |
| abstract_inverted_index.survivors | 84, 209, 245 |
| abstract_inverted_index.treatment | 177 |
| abstract_inverted_index.variants. | 304 |
| abstract_inverted_index.0.65-0.95) | 280 |
| abstract_inverted_index.0.68-0.97) | 270 |
| abstract_inverted_index.Importance | 0 |
| abstract_inverted_index.Late-onset | 145 |
| abstract_inverted_index.Objectives | 46 |
| abstract_inverted_index.associated | 24, 37, 282, 309, 329, 389 |
| abstract_inverted_index.clinically | 111 |
| abstract_inverted_index.diagnosis, | 217, 232 |
| abstract_inverted_index.exposures. | 178 |
| abstract_inverted_index.late-onset | 62, 168, 288, 311, 395 |
| abstract_inverted_index.parameters | 184 |
| abstract_inverted_index.radiation. | 106 |
| abstract_inverted_index.regression | 153 |
| abstract_inverted_index.survivors, | 294, 322, 400 |
| abstract_inverted_index.survivors. | 12, 68, 318 |
| abstract_inverted_index.Conclusions | 371 |
| abstract_inverted_index.Terminology | 124 |
| abstract_inverted_index.[23.0-41.0] | 234 |
| abstract_inverted_index.[28.0-42.3] | 219 |
| abstract_inverted_index.approaches. | 201 |
| abstract_inverted_index.association | 159, 296 |
| abstract_inverted_index.demographic | 174 |
| abstract_inverted_index.population, | 16 |
| abstract_inverted_index.prospective | 79 |
| abstract_inverted_index.rs2234962-C | 272, 326 |
| abstract_inverted_index.rs3829746-C | 262, 324 |
| abstract_inverted_index.ventricular | 333, 360 |
| abstract_inverted_index.Participants | 72 |
| abstract_inverted_index.association. | 406 |
| abstract_inverted_index.associations | 49 |
| abstract_inverted_index.end-systolic | 334 |
| abstract_inverted_index.longitudinal | 346 |
| abstract_inverted_index.Multivariable | 151 |
| abstract_inverted_index.meta-analytic | 200 |
| abstract_inverted_index.respectively) | 343 |
| abstract_inverted_index.retrospective | 74 |
| abstract_inverted_index.self-reported | 116 |
| abstract_inverted_index.anthracyclines | 103 |
| abstract_inverted_index.cardiomyopathy | 3, 109 |
| abstract_inverted_index.chest-directed | 105 |
| abstract_inverted_index.respectively). | 370 |
| abstract_inverted_index.Cohort-specific | 195 |
| abstract_inverted_index.cardiomyopathy, | 32 |
| abstract_inverted_index.cardiomyopathy. | 45 |
| abstract_inverted_index.protein-altering | 54 |
| abstract_inverted_index.echocardiographic | 183 |
| abstract_inverted_index.therapy–related | 2, 108 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 21 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8199999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.882442 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |