Ivermectin exposures reported to the Poisons Information Helpline in South Africa during the COVID-19 pandemic Article Swipe
Veshni Pillay-Fuentes Lorente
,
G Voigt
,
C E Du Plessis
,
K Balme
,
Carine Marks
,
Eric Decloedt
,
Cindy Stephen
,
Helmuth Reuter
,
Roland van Rensburg
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.7196/samj.2022.v112i8.16473
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.7196/samj.2022.v112i8.16473
Background. Ivermectin is an antiparasitic drug that has shown in vitro activity against COVID‑19. Clinical studies supporting ivermectin for COVID‑19 prevention and treatment are conflicting, with important limitations. Public support for ivermectin is significant, with extensive off-label use despite the conflicting views on its efficacy. Ivermectin tablets and injectable formulations are not registered in South Africa for human use by the South African Health Products Regulatory Authority. The National Department of Health does not currently recommend the use of ivermectin for COVID‑19.Objectives. To describe cases of ivermectin exposure reported to the Poisons Information Helpline of the Western Cape (PIHWC) before and after publication of the drug’s in vitro activity against SARS-CoV-2.Methods. In a retrospective review, ivermectin-related calls reported to the PIHWC from 1 June 2015 to 30 June 2020 (period 1) were compared with calls received from 1 July 2020 to 31 July 2021 (period 2), dichotomised according to the first publication indicating ivermectin activity against SARS-CoV-2.Results. Seventy-one cases were screened, and 65 were included for analysis; 19 cases were reported during period 1 and 46 during period 2. During period 2, 25 ivermectin cases (54.3%) were related to COVID‑19 use. Of these, 24 cases (52.2%) involved veterinary preparations, 3 (6.5%) human preparations and 19 (41.3%) unknown preparations. Fourteen cases (73.7%) during period 1 and 30 (65.2%) during period 2 were reported to be symptomatic. The most common organ systems involved were the central nervous (n=26 cases; 40.0%), gastrointestinal (n=18; 27.7%), ocular (n=9; 13.8%) and dermatological (n=5; 7.7%) systems.Conclusion. Ivermectin-related exposure calls increased during study period 2, probably as a result of ivermectin being used as preventive and definitive therapy for COVID‑19 in the absence of robust evidence on efficacy, dosing recommendations or appropriate formulations.
Related Topics
Concepts
Ivermectin
Medicine
Antiparasitic agent
Pandemic
Public health
Veterinary medicine
Coronavirus disease 2019 (COVID-19)
Internal medicine
Disease
Pathology
Infectious disease (medical specialty)
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7196/samj.2022.v112i8.16473
- https://samajournals.co.za/index.php/samj/article/download/99/77
- OA Status
- gold
- Cited By
- 2
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4289517948
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4289517948Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7196/samj.2022.v112i8.16473Digital Object Identifier
- Title
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Ivermectin exposures reported to the Poisons Information Helpline in South Africa during the COVID-19 pandemicWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-08-02Full publication date if available
- Authors
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Veshni Pillay-Fuentes Lorente, G Voigt, C E Du Plessis, K Balme, Carine Marks, Eric Decloedt, Cindy Stephen, Helmuth Reuter, Roland van RensburgList of authors in order
- Landing page
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https://doi.org/10.7196/samj.2022.v112i8.16473Publisher landing page
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https://samajournals.co.za/index.php/samj/article/download/99/77Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://samajournals.co.za/index.php/samj/article/download/99/77Direct OA link when available
- Concepts
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Ivermectin, Medicine, Antiparasitic agent, Pandemic, Public health, Veterinary medicine, Coronavirus disease 2019 (COVID-19), Internal medicine, Disease, Pathology, Infectious disease (medical specialty)Top concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 1, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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19Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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