JHEP at a glance (April 2023) Article Swipe
Yi Mak
,
Ed Gane
,
Christian Schwabe
,
Min Yi
,
James Hamilton
,
Man–Fung Yuen
,
K. W. Yoon
,
Jeong Heo
,
Russell Scott
,
Jeong‐Hoon Lee
,
Jung Hun Lee
,
Young Oh Kweon
,
Martin Weltman
,
Stephen Harrison
,
Brent A. Neuschwander‐Tetri
,
Kenneth Cusi
,
Rohit Loomba
,
Bruce D. Given
,
Dawn R. Christianson
,
Eric Garcia-Medel
,
Man Fung
,
Yuen Jhepatol
,
Arun J. Sanyal
,
Stephen J. Williams
,
Joel E. Lavine
,
Yi Jia
,
Katherine Yates
,
James Tonascia
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/s0168-8278(23)00042-9
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/s0168-8278(23)00042-9
ARO-HSD is a hepatocyte targeted siRNA therapeutic designed to silence HSD17β13 expression g D17β13 express ARO-HSD Favorable safety profile ARO-HSD was well tolerated with no treatment-related serious adverse events or drug discontinuations Proof of concept In this proof-of-concept study, ARO-HSD was well tolerated and able to significantly reduce HSD17β13 expression in a group of 18 patients, resulting in an improvement in markers of liver injury 18 Patients with suspected or confirmed NASH 16 Healthy volunteers ALT reduction -42.3% Mean change from baseline at day 71 at 200 mg HSD17β13 loss-of-function mutations have been shown to protect against alcoholic and non-alcoholic liver disease including NASH 16 Hepatic HSD17β13 mRNA reduction-93.4%Reduction from baseline at day 71 at 200 mg Hepatic HSD17β13 protein reduction -83.0%Reduction from baseline at day 71 at 200 mg Highlights HSD17B13 loss-of-function mutations are protective against alcohol-related and non-alcoholic liver disease, including NASH.ARO-HSD is a hepatocyte-targeted siRNA therapeutic designed to silence HSD17B13 expression.ARO-HSD demonstrated a favorable safety profile in healthy volunteers and patients with suspected NASH.Mean change from baseline at Day 71 in hepatic HSD17b13 mRNA was -93.4% (ARO-HSD 200 mg).
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/s0168-8278(23)00042-9
- https://doi.org/10.1016/s0168-8278(23)00042-9
- OA Status
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4327531550Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/s0168-8278(23)00042-9Digital Object Identifier
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JHEP at a glance (April 2023)Work title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-03-15Full publication date if available
- Authors
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Yi Mak, Ed Gane, Christian Schwabe, Min Yi, James Hamilton, Man–Fung Yuen, K. W. Yoon, Jeong Heo, Russell Scott, Jeong‐Hoon Lee, Jung Hun Lee, Young Oh Kweon, Martin Weltman, Stephen Harrison, Brent A. Neuschwander‐Tetri, Kenneth Cusi, Rohit Loomba, Bruce D. Given, Dawn R. Christianson, Eric Garcia-Medel, Man Fung, Yuen Jhepatol, Arun J. Sanyal, Stephen J. Williams, Joel E. Lavine, Yi Jia, Katherine Yates, James TonasciaList of authors in order
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https://doi.org/10.1016/s0168-8278(23)00042-9Publisher landing page
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https://doi.org/10.1016/s0168-8278(23)00042-9Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/s0168-8278(23)00042-9Direct OA link when available
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Computational biology, Chemistry, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.-42.3% | 77 |
| abstract_inverted_index.-93.4% | 178 |
| abstract_inverted_index.change | 79, 167 |
| abstract_inverted_index.events | 28 |
| abstract_inverted_index.injury | 64 |
| abstract_inverted_index.reduce | 47 |
| abstract_inverted_index.safety | 17, 157 |
| abstract_inverted_index.study, | 38 |
| abstract_inverted_index.ARO-HSD | 0, 15, 19, 39 |
| abstract_inverted_index.D17β13 | 13 |
| abstract_inverted_index.Healthy | 73 |
| abstract_inverted_index.Hepatic | 105, 117 |
| abstract_inverted_index.adverse | 27 |
| abstract_inverted_index.against | 96, 136 |
| abstract_inverted_index.concept | 34 |
| abstract_inverted_index.disease | 101 |
| abstract_inverted_index.express | 14 |
| abstract_inverted_index.healthy | 160 |
| abstract_inverted_index.hepatic | 174 |
| abstract_inverted_index.markers | 61 |
| abstract_inverted_index.profile | 18, 158 |
| abstract_inverted_index.protect | 95 |
| abstract_inverted_index.protein | 119 |
| abstract_inverted_index.serious | 26 |
| abstract_inverted_index.silence | 9, 151 |
| abstract_inverted_index.(ARO-HSD | 179 |
| abstract_inverted_index.HSD17B13 | 131, 152 |
| abstract_inverted_index.HSD17b13 | 175 |
| abstract_inverted_index.Patients | 66 |
| abstract_inverted_index.baseline | 81, 110, 123, 169 |
| abstract_inverted_index.designed | 7, 149 |
| abstract_inverted_index.disease, | 141 |
| abstract_inverted_index.patients | 163 |
| abstract_inverted_index.targeted | 4 |
| abstract_inverted_index.Favorable | 16 |
| abstract_inverted_index.HSD17β13 | 10, 48, 88, 106, 118 |
| abstract_inverted_index.NASH.Mean | 166 |
| abstract_inverted_index.alcoholic | 97 |
| abstract_inverted_index.confirmed | 70 |
| abstract_inverted_index.favorable | 156 |
| abstract_inverted_index.including | 102, 142 |
| abstract_inverted_index.mutations | 90, 133 |
| abstract_inverted_index.patients, | 55 |
| abstract_inverted_index.reduction | 76, 120 |
| abstract_inverted_index.resulting | 56 |
| abstract_inverted_index.suspected | 68, 165 |
| abstract_inverted_index.tolerated | 22, 42 |
| abstract_inverted_index.Highlights | 130 |
| abstract_inverted_index.expression | 11, 49 |
| abstract_inverted_index.hepatocyte | 3 |
| abstract_inverted_index.protective | 135 |
| abstract_inverted_index.volunteers | 74, 161 |
| abstract_inverted_index.improvement | 59 |
| abstract_inverted_index.therapeutic | 6, 148 |
| abstract_inverted_index.NASH.ARO-HSD | 143 |
| abstract_inverted_index.demonstrated | 154 |
| abstract_inverted_index.non-alcoholic | 99, 139 |
| abstract_inverted_index.significantly | 46 |
| abstract_inverted_index.-83.0%Reduction | 121 |
| abstract_inverted_index.alcohol-related | 137 |
| abstract_inverted_index.discontinuations | 31 |
| abstract_inverted_index.loss-of-function | 89, 132 |
| abstract_inverted_index.proof-of-concept | 37 |
| abstract_inverted_index.treatment-related | 25 |
| abstract_inverted_index.expression.ARO-HSD | 153 |
| abstract_inverted_index.hepatocyte-targeted | 146 |
| abstract_inverted_index.reduction-93.4%Reduction | 108 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 28 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/13 |
| sustainable_development_goals[0].score | 0.5699999928474426 |
| sustainable_development_goals[0].display_name | Climate action |
| citation_normalized_percentile.value | 0.05469473 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |