JS09.6.A ADVANCING THE MINIMALLY INVASIVE CNS-TUMOR CLASSIFICATION: A COMPARATIVE STUDY OF LIQUID BIOPSY APPROACHES USING NANOPORE SEQUENCING AND PANEL-BASED NGS OF CEREBROSPINAL FLUID CTDNA

Exploring foci of: Neuro-Oncology • Vol 27 • No Supplement_3 JS09.6.A ADVANCING THE MINIMALLY INVASIVE CNS-TUMOR CLASSIFICATION: A COMPARATIVE STUDY OF LIQUID BIOPSY APPROACHES USING NANOPORE SEQUENCING AND PANEL-BASED NGS OF CEREBROSPINAL FLUID CTDNA October 2025 • Sebastian Schulz, Paul Kerbs, Florian Iser, Kirsten Göbel, Areeba Patel, V Kelbch, L Ehret-Maßholder, Eve Fouarge, Pauline Göller, Daniel Schrimpf, M… Abstract BACKGROUND Cerebrospinal fluid (CSF) liquid biopsy (LB) enables minimally invasive molecular profiling of central nervous system (CNS) tumors. We compared targeted next-generation sequencing (NGS) and whole-genome Oxford Nanopore sequencing (ONT) regarding diagnostic yield, turnaround time (TAT), and clinical utility. MATERIAL AND METHODS CSF cell-free DNA (cfDNA) from 60 patients with suspected CNS tumors was analyzed across two centers. In all cases, both NGS and ONT were performed on the same cfDNA ali… Open Article Page

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