Junctional adhesion molecule-A is dispensable for myeloid cell recruitment and diversification in the tumor microenvironment Article Swipe
Máté Kiss
,
Els Lebegge
,
Aleksandar Murgaski
,
Helena Van Damme
,
Daliya Kancheva
,
Jan Brughmans
,
Isabelle Scheyltjens
,
Ali Talebi
,
Robin Maximilian Awad
,
Yvon Elkrim
,
Pauline M. R. Bardet
,
Sana M. Arnouk
,
Cleo Goyvaerts
,
Johan Swinnen
,
Frank Aboubakar Nana
,
Jo A. Van Ginderachter
,
Damya Laoui
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2022.1003975
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2022.1003975
Junctional adhesion molecule-A (JAM-A), expressed on the surface of myeloid cells, is required for extravasation at sites of inflammation and may also modulate myeloid cell activation. Infiltration of myeloid cells is a common feature of tumors that drives disease progression, but the function of JAM-A in this phenomenon and its impact on tumor-infiltrating myeloid cells is little understood. Here we show that systemic cancer-associated inflammation in mice enhanced JAM-A expression selectively on circulating monocytes in an IL1β-dependent manner. Using myeloid-specific JAM-A-deficient mice, we found that JAM-A was dispensable for recruitment of monocytes and other myeloid cells to tumors, in contrast to its reported role in inflammation. Single-cell RNA sequencing revealed that loss of JAM-A did not influence the transcriptional reprogramming of myeloid cells in the tumor microenvironment. Overall, our results support the notion that cancer-associated inflammation can modulate the phenotype of circulating immune cells, and we demonstrate that tumors can bypass the requirement of JAM-A for myeloid cell recruitment and reprogramming.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2022.1003975
- OA Status
- gold
- Cited By
- 5
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4310523804
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4310523804Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2022.1003975Digital Object Identifier
- Title
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Junctional adhesion molecule-A is dispensable for myeloid cell recruitment and diversification in the tumor microenvironmentWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-12-01Full publication date if available
- Authors
-
Máté Kiss, Els Lebegge, Aleksandar Murgaski, Helena Van Damme, Daliya Kancheva, Jan Brughmans, Isabelle Scheyltjens, Ali Talebi, Robin Maximilian Awad, Yvon Elkrim, Pauline M. R. Bardet, Sana M. Arnouk, Cleo Goyvaerts, Johan Swinnen, Frank Aboubakar Nana, Jo A. Van Ginderachter, Damya LaouiList of authors in order
- Landing page
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https://doi.org/10.3389/fimmu.2022.1003975Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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-
https://doi.org/10.3389/fimmu.2022.1003975Direct OA link when available
- Concepts
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Myeloid, Tumor microenvironment, Inflammation, Reprogramming, Biology, Cell biology, Immune system, Cancer research, Immunology, Cell, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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46Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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