Kappa-carrageenan-Functionalization of octacalcium phosphate-coated titanium Discs enhances pre-osteoblast behavior and osteogenic differentiation Article Swipe
Wei Cao
,
Jianfeng Jin
,
Gang Wu
,
Nathalie Bravenboer
,
Marco N. Helder
,
E.A.J.M. Schulten
,
Rommel G. Bacabac
,
Janak L. Pathak
,
Jenneke Klein‐Nulend
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fbioe.2022.1011853
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fbioe.2022.1011853
Bioactive coatings are promising for improving osseointegration and the long-term success of titanium dental or orthopaedic implants. Biomimetic octacalcium phosphate (OCP) coating can be used as a carrier for osteoinductive agents. κ-Carrageenan, a highly hydrophilic and biocompatible seaweed-derived sulfated-polysaccharide, promotes pre-osteoblast activity required for bone regeneration. Whether κ-carrageenan can functionalize OCP-coating to enhance osseointegration of titanium implants is unclear. This study aimed to analyze carrageenan-functionalized biomimetic OCP-coated titanium structure, and effects of carrageenan functionalization on pre-osteoblast behavior and osteogenic differentiation. Titanium discs were coated with OCP/κ-carrageenan at 0.125–2 mg/ml OCP solution, and physicochemical and biological properties were investigated. κ-Carrageenan (2 mg/ml) in the OCP coating of titanium discs decreased the pore size in the sheet-like OCP crystal by 41.32%. None of the κ-carrageenan concentrations tested in the OCP-coating did affect hydrophilicity. However, κ-carrageenan (2 mg/ml) increased (1.26-fold) MC3T3-E1 pre-osteoblast spreading at 1 h i.e., κ-Carrageenan in the OCP-coating increased pre-osteoblast proliferation (max. 1.92-fold at 2 mg/ml, day 1), metabolic activity (max. 1.50-fold at 2 mg/ml, day 3), and alkaline phosphatase protein (max. 4.21-fold at 2 mg/ml, day 3), as well as matrix mineralization (max. 5.45-fold at 2 mg/ml, day 21). κ-Carrageenan (2 mg/ml) in the OCP-coating increased gene expression of Mepe (4.93-fold) at day 14, and Runx2 (2.94-fold), Opn (3.59-fold), Fgf2 (3.47-fold), Ocn (3.88-fold), and Dmp1 (4.59-fold) at day 21 in pre-osteoblasts. In conclusion, κ-carrageenan modified the morphology and microstructure of OCP-coating on titanium discs, and enhanced pre-osteoblast metabolic activity, proliferation, and osteogenic differentiation. This suggests that κ-carrageenan-functionalized OCP coating may be promising for in vivo improvement of titanium implant osseointegration.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fbioe.2022.1011853
- OA Status
- gold
- Cited By
- 7
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4306929366
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4306929366Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fbioe.2022.1011853Digital Object Identifier
- Title
-
Kappa-carrageenan-Functionalization of octacalcium phosphate-coated titanium Discs enhances pre-osteoblast behavior and osteogenic differentiationWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-10-20Full publication date if available
- Authors
-
Wei Cao, Jianfeng Jin, Gang Wu, Nathalie Bravenboer, Marco N. Helder, E.A.J.M. Schulten, Rommel G. Bacabac, Janak L. Pathak, Jenneke Klein‐NulendList of authors in order
- Landing page
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https://doi.org/10.3389/fbioe.2022.1011853Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fbioe.2022.1011853Direct OA link when available
- Concepts
-
Octacalcium phosphate, Osteoblast, Titanium, Carrageenan, Chemistry, Osseointegration, Coating, Surface modification, Alkaline phosphatase, RUNX2, Chemical engineering, Nuclear chemistry, Phosphate, Biochemistry, Organic chemistry, Implant, In vitro, Enzyme, Surgery, Medicine, Engineering, Physical chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 3, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
49Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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