Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses Article Swipe

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Mouer Wang , Bernard Rousseau , Ke Qiu , Gang Huang , Yu Zhang , Helen C. Su , Christine Le Bihan-Benjamin , Ines Khati , Oliver Artz , Michael B. Foote , Yahong Cheng , K.-H Lee , Michael Z. Miao , Yao Sun , Philippe‐Jean Bousquet , Mustofa Hilmi , Élise Dumas , Anne‐Sophie Hamy , Fabien Reyal , Lin Li , Paul M. Armistead , Wei Song , Ava M. Vargason , Janelle C. Arthur , Yanyong Liu , Jian-Rong Guo , Xun Zhou , Jenny Nguyen , Ying He , Jenny P.-Y. Ting , Aaron C. Anselmo , Ling Huang ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.17615/dfby-4m46

Increasing evidence implicates the tumor microbiota as a factor that can influence cancer progression. In patients with colorectal cancer (CRC), we found that pre-resection antibiotics targeting anaerobic bacteria substantially improved disease-free survival by 25.5%. For mouse studies, we designed an antibiotic silver-tinidazole complex encapsulated in liposomes (LipoAgTNZ) to eliminate tumor-associated bacteria in the primary tumor and liver metastases without causing gut microbiome dysbiosis. Mouse CRC models colonized by tumor-promoting bacteria (Fusobacterium nucleatum spp.) or probiotics (Escherichia coli Nissle spp.) responded to LipoAgTNZ therapy, which enabled more than 70% long-term survival in two F. nucleatum-infected CRC models. The antibiotic treatment generated microbial neoantigens that elicited anti-tumor CD8+ T cells. Heterologous and homologous bacterial epitopes contributed to the immunogenicity, priming T cells to recognize both infected and uninfected tumors. Our strategy targets tumor-associated bacteria to elicit anti-tumoral immunity, paving the way for microbiome–immunotherapy interventions.

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Immune system Bacteria Antibiotics Liposome Microbiology Biology Immunology Medicine Genetics Biochemistry

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Type: article
Language: en
Landing Page: https://doi.org/10.17615/dfby-4m46
PDF: https://doi.org/10.17615/dfby-4m46
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Related Works: 10
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DOI: https://doi.org/10.17615/dfby-4m46

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Title: Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses

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Language: en

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Publication year: 2023

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Publication date: 2023-01-01

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Authors: Mouer Wang, Bernard Rousseau, Ke Qiu, Gang Huang, Yu Zhang, Helen C. Su, Christine Le Bihan-Benjamin, Ines Khati, Oliver Artz, Michael B. Foote, Yahong Cheng, K.-H Lee, Michael Z. Miao, Yao Sun, Philippe‐Jean Bousquet, Mustofa Hilmi, Élise Dumas, Anne‐Sophie Hamy, Fabien Reyal, Lin Li, Paul M. Armistead, Wei Song, Ava M. Vargason, Janelle C. Arthur, Yanyong Liu, Jian-Rong Guo, Xun Zhou, Jenny Nguyen, Ying He, Jenny P.-Y. Ting, Aaron C. Anselmo, Ling Huang

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Landing page: https://doi.org/10.17615/dfby-4m46

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Concepts: Immune system, Bacteria, Antibiotics, Liposome, Microbiology, Biology, Immunology, Medicine, Genetics, Biochemistry

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primary_location.is_published	False
primary_location.raw_source_name	Nature Biotechnology
primary_location.landing_page_url	https://doi.org/10.17615/dfby-4m46
publication_date	2023-01-01
publication_year	2023
referenced_works_count	0
abstract_inverted_index.T	106, 118
abstract_inverted_index.a	7
abstract_inverted_index.F.	92
abstract_inverted_index.In	14
abstract_inverted_index.an	39
abstract_inverted_index.as	6
abstract_inverted_index.by	32, 67
abstract_inverted_index.in	44, 51, 90
abstract_inverted_index.or	73
abstract_inverted_index.to	47, 80, 114, 120, 132
abstract_inverted_index.we	20, 37
abstract_inverted_index.70%	87
abstract_inverted_index.CRC	64, 94
abstract_inverted_index.For	34
abstract_inverted_index.Our	127
abstract_inverted_index.The	96
abstract_inverted_index.and	55, 109, 124
abstract_inverted_index.can	10
abstract_inverted_index.for	139
abstract_inverted_index.gut	60
abstract_inverted_index.the	3, 52, 115, 137
abstract_inverted_index.two	91
abstract_inverted_index.way	138
abstract_inverted_index.CD8+	105
abstract_inverted_index.both	122
abstract_inverted_index.coli	76
abstract_inverted_index.more	85
abstract_inverted_index.than	86
abstract_inverted_index.that	9, 22, 102
abstract_inverted_index.with	16
abstract_inverted_index.Mouse	63
abstract_inverted_index.cells	119
abstract_inverted_index.found	21
abstract_inverted_index.liver	56
abstract_inverted_index.mouse	35
abstract_inverted_index.spp.)	72, 78
abstract_inverted_index.tumor	4, 54
abstract_inverted_index.which	83
abstract_inverted_index.(CRC),	19
abstract_inverted_index.25.5%.	33
abstract_inverted_index.Nissle	77
abstract_inverted_index.cancer	12, 18
abstract_inverted_index.cells.	107
abstract_inverted_index.elicit	133
abstract_inverted_index.factor	8
abstract_inverted_index.models	65
abstract_inverted_index.paving	136
abstract_inverted_index.causing	59
abstract_inverted_index.complex	42
abstract_inverted_index.enabled	84
abstract_inverted_index.models.	95
abstract_inverted_index.primary	53
abstract_inverted_index.priming	117
abstract_inverted_index.targets	129
abstract_inverted_index.tumors.	126
abstract_inverted_index.without	58
abstract_inverted_index.bacteria	27, 50, 69, 131
abstract_inverted_index.designed	38
abstract_inverted_index.elicited	103
abstract_inverted_index.epitopes	112
abstract_inverted_index.evidence	1
abstract_inverted_index.improved	29
abstract_inverted_index.infected	123
abstract_inverted_index.patients	15
abstract_inverted_index.strategy	128
abstract_inverted_index.studies,	36
abstract_inverted_index.survival	31, 89
abstract_inverted_index.therapy,	82
abstract_inverted_index.LipoAgTNZ	81
abstract_inverted_index.anaerobic	26
abstract_inverted_index.bacterial	111
abstract_inverted_index.colonized	66
abstract_inverted_index.eliminate	48
abstract_inverted_index.generated	99
abstract_inverted_index.immunity,	135
abstract_inverted_index.influence	11
abstract_inverted_index.liposomes	45
abstract_inverted_index.long-term	88
abstract_inverted_index.microbial	100
abstract_inverted_index.nucleatum	71
abstract_inverted_index.recognize	121
abstract_inverted_index.responded	79
abstract_inverted_index.targeting	25
abstract_inverted_index.treatment	98
abstract_inverted_index.Increasing	0
abstract_inverted_index.anti-tumor	104
abstract_inverted_index.antibiotic	40, 97
abstract_inverted_index.colorectal	17
abstract_inverted_index.dysbiosis.	62
abstract_inverted_index.homologous	110
abstract_inverted_index.implicates	2
abstract_inverted_index.metastases	57
abstract_inverted_index.microbiome	61
abstract_inverted_index.microbiota	5
abstract_inverted_index.probiotics	74
abstract_inverted_index.uninfected	125
abstract_inverted_index.(LipoAgTNZ)	46
abstract_inverted_index.antibiotics	24
abstract_inverted_index.contributed	113
abstract_inverted_index.neoantigens	101
abstract_inverted_index.(Escherichia	75
abstract_inverted_index.Heterologous	108
abstract_inverted_index.anti-tumoral	134
abstract_inverted_index.disease-free	30
abstract_inverted_index.encapsulated	43
abstract_inverted_index.progression.	13
abstract_inverted_index.pre-resection	23
abstract_inverted_index.substantially	28
abstract_inverted_index.(Fusobacterium	70
abstract_inverted_index.interventions.	141
abstract_inverted_index.immunogenicity,	116
abstract_inverted_index.tumor-promoting	68
abstract_inverted_index.tumor-associated	49, 130
abstract_inverted_index.silver-tinidazole	41
abstract_inverted_index.nucleatum-infected	93
abstract_inverted_index.microbiome–immunotherapy	140
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	32
citation_normalized_percentile.value	0.4627228
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False